AB1025 Chronic Recurrent Multifocal Osteomyelitis (CRMO): The Importance of an Accurate Differential Diagnosis

2015 ◽  
Vol 74 (Suppl 2) ◽  
pp. 1241.2-1241
Author(s):  
T. Giani ◽  
L. Capirchio ◽  
A. Marino ◽  
F. Bertini ◽  
A. Mauro ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Chronic Recurrent Multifocal Osteomyelitis ◽  
Multifocal Osteomyelitis

scholarly journals Schnitzler's Disease as an Important Differential Diagnosis of Chronic Recurrent Multifocal Osteomyelitis: A Case Report

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
Kathrin Schrödl ◽  
Axel Nigg ◽  
Marcus Treitl ◽  
Michael Flaig ◽  
Annette Jansson ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Bone Marrow ◽  
Differential Diagnosis ◽  
Magnetic Resonance ◽  
Bone Marrow Involvement ◽  
Chronic Recurrent Multifocal Osteomyelitis ◽  
Blood Analysis ◽  
Resonance Imaging ◽  
Important Differential Diagnosis ◽  
Multifocal Osteomyelitis

Introduction. At first sight, chronic recurrent multifocal osteomyelitis (CRMO) and Schnitzler's disease are diagnoses of exclusion and can be similar in their manifestation.Methods. In this paper we present the reevaluation of the 13-year-old diagnosis of chronic recurrent osteomyelitis of a 58-year-old man with chronic ostealgia, night sweat, and pruritic urticarial lesions on the extremities and trunk. For further examination, we performed blood analysis, bone and skin biopsies, CT scans, and magnetic resonance imaging.Results. Laboratory findings showed increased inflammation parameters. Magnetic resonance imaging (MRI) revealed a diffuse bone marrow infiltration. A bone and skin biopsy showed a sclerotic bone marrow involvement and a superficial dermal and perivascular infiltrate of neutrophils. Based on these findings, the diagnosis of Schnitzler’s disease was made.Conclusion. Here, we want to present Schnitzler's disease as an important differential diagnosis to CRMO in adults presenting with signs suggestive of CRMO.

scholarly journals NEUROBLASTOMA AS A DIFFERENTIAL DIAGNOSIS OF CHRONIC RECURRENT MULTIFOCAL OSTEOMYELITIS (CRMO): CASE REPORT

2021 ◽  
Author(s):  
Rodrigo Maldonado Franco ◽  
Ana Caroline Oliveira de Lima Grossi ◽  
Bruno Carnevalli ◽  
Gustavo Lawin ◽  
Milene Tieno Sakata Vasconcellos ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Chronic Recurrent Multifocal Osteomyelitis ◽  
Multifocal Osteomyelitis

THE "SAPHO" SYNDROME: A CASE REPORT OF A PATIENT WITH AN ACCIDENTAL FINDING OF HYPEROSTOSIS IN PLAIN X-RAYS OF THORAX

2008 ◽  
Vol 11 (01) ◽  
pp. 29-35
Author(s):  
M. Pyrgioti ◽  
E. Mahaira ◽  
G. Papagiannakis ◽  
A. Syrou ◽  
I. H. Alexandris ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Health Status ◽  
Bone Tissue ◽  
Laboratory Tests ◽  
Chronic Recurrent Multifocal Osteomyelitis ◽  
Sapho Syndrome ◽  
X Rays ◽  
Multifocal Osteomyelitis ◽  
Histopathologic Findings

The authors describe the clinical, bone scintigraphy, and histopathologic findings of chronic recurrent multifocal osteomyelitis (CRMO), which is considered to be part of the SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) syndrome. Knowledge of this disorder may help in the differential diagnosis of arthritis, and it will help avoid repeated biopsies. We report the case of a 52-year-old man who was admitted to hospital due to an accidental finding in plain X-rays during his first check-up of his health status. He underwent laboratory tests, imaging examinations, and biopsy and histopathologic examinations of bone tissue; and was diagnosed with the SAPHO syndrome (CRMO).

Chronic recurrent multifocal osteomyelitis in children: a new, MRI-based method of quantifying inflammation in the bone

2015 ◽  
Author(s):  
Dionysios Alexandrou ◽  
Benjamin Jacobs ◽  
O'Donnell Paul ◽  
Rikin Hargunani ◽  
Ananya Guha ◽  
...  
Keyword(s):  
Chronic Recurrent Multifocal Osteomyelitis ◽  
Multifocal Osteomyelitis

Chronic recurrent multifocal osteomyelitis in children

1988 ◽  
Vol 29 (5) ◽  
pp. 565-570 ◽  
Author(s):  
W. Mortensson ◽  
G. Edeburn ◽  
M. Fries ◽  
R. Nilsson
Keyword(s):  
Chronic Recurrent Multifocal Osteomyelitis ◽  
Multifocal Osteomyelitis

scholarly journals Patient-reported effectiveness and safety of Pamidronate in NSAIDs-refractory chronic recurrent multifocal osteomyelitis in children

2021 ◽  
Author(s):  
Bartłomiej Juszczak ◽  
Jerzy Sułko
Keyword(s):  
Adverse Drug Reactions ◽  
Social Life ◽  
Chronic Recurrent Multifocal Osteomyelitis ◽  
Daily Activities ◽  
Drug Reactions ◽  
Patient Reported ◽  
Multifocal Osteomyelitis ◽  
Drug Dependent ◽  
Treatment Onset ◽  
The Impact

AbstractTo evaluate patient-reported effectiveness, safety and social influence of Pamidronate in the therapy of NSAIDs-refractory Chronic Recurrent Multifocal Osteomyelitis in children. Authors reviewed self-created questionnaires, which asked patients for symptoms alleviation, adverse drug reactions frequency and degree of severity and daily activities self-reliance. Only surveys with complete answers, which were returned to authors by an e-mail from juvenile patients treated for NSAIDs-refractory Chronic Recurrent Multifocal Osteomyelitis at the University Children’s Hospital of Cracow were analyzed. Between 2010 and 2019, 61 children were diagnosed with NSAIDs-refractory Chronic Recurrent Multifocal Osteomyelitis at our department. Out of 61 requests sent, 42 complete replies (33 females, 9 males) were gathered and analyzed. All patients included in this research were administered with at least one set of Pamidronate intravenously in the dose of 1 mg/kg/day for 3 consecutive days. Our analysis shows remarkable in terms of patient’s impressions decrease of pain intensity after 2.5 series of Pamidronate on average, and total pain resolution after 5.9 series on average. Overall number of adverse drug reaction events reported by responders was 105. One patient developed drug-dependent renal insufficiency in the course of therapy. Outcome assessment indicates that nearly 50% of the studied population was more eager to participate in social life just after the first infusion of the drug. 95% of the surveyed unanimously agreed to recommend Pamidronate therapy to cure NSAIDs-refractory CRMO. 39 out of 42 (93%) patients considered Pamidronate effective at the end of the treatment. Onset of Pamidronate’s action is gradual and differs in terms of symptoms alleviation between sexes. The therapy can induce considerable number of adverse drug reactions (2.5 per patient). Only 3 out of 42 (7%) patients were free from any ADRs. To demonstrate the impact of the use of Pamidronate on daily activities more precisely, further research with quantification of the quality of life is warranted.

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