THE "SAPHO" SYNDROME: A CASE REPORT OF A PATIENT WITH AN ACCIDENTAL FINDING OF HYPEROSTOSIS IN PLAIN X-RAYS OF THORAX

The authors describe the clinical, bone scintigraphy, and histopathologic findings of chronic recurrent multifocal osteomyelitis (CRMO), which is considered to be part of the SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) syndrome. Knowledge of this disorder may help in the differential diagnosis of arthritis, and it will help avoid repeated biopsies. We report the case of a 52-year-old man who was admitted to hospital due to an accidental finding in plain X-rays during his first check-up of his health status. He underwent laboratory tests, imaging examinations, and biopsy and histopathologic examinations of bone tissue; and was diagnosed with the SAPHO syndrome (CRMO).

Download Full-text

NEUROBLASTOMA AS A DIFFERENTIAL DIAGNOSIS OF CHRONIC RECURRENT MULTIFOCAL OSTEOMYELITIS (CRMO): CASE REPORT

10.47660/cbr.2021.1755 ◽

2021 ◽

Author(s):

Rodrigo Maldonado Franco ◽

Ana Caroline Oliveira de Lima Grossi ◽

Bruno Carnevalli ◽

Gustavo Lawin ◽

Milene Tieno Sakata Vasconcellos ◽

...

Keyword(s):

Differential Diagnosis ◽

Case Report ◽

Chronic Recurrent Multifocal Osteomyelitis ◽

Multifocal Osteomyelitis

Download Full-text

Acne with chronic recurrent multifocal osteomyelitis involvingthe mandible as part of the SAPHO syndrome: case report

British Journal of Oral and Maxillofacial Surgery ◽

10.1054/bjom.2000.0591 ◽

2001 ◽

Vol 39 (2) ◽

pp. 141-144 ◽

Cited By ~ 26

Author(s):

J.C. Roldán ◽

H. Terheyden ◽

A. Dunsche ◽

W.U. Kampen ◽

J.O. Schroeder

Keyword(s):

Case Report ◽

Chronic Recurrent Multifocal Osteomyelitis ◽

Sapho Syndrome ◽

Multifocal Osteomyelitis

Download Full-text

Myositis as a Disease Manifestation of Chronic Recurrent Multifocal Osteomyelitis: A case report.

10.47660/cbr.2021.1916 ◽

2021 ◽

Author(s):

Vinicius Verlangieri Soubihe ◽

Diego de Paula Ferreira Nunes ◽

Raíssa Dudienas Domingues Pereira ◽

Caio Rustichelli Cardoso ◽

Thaís Ferrarini Tavares ◽

...

Keyword(s):

Case Report ◽

Chronic Recurrent Multifocal Osteomyelitis ◽

Disease Manifestation ◽

Multifocal Osteomyelitis

Download Full-text

AB1025 Chronic Recurrent Multifocal Osteomyelitis (CRMO): The Importance of an Accurate Differential Diagnosis

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2015-eular.4710 ◽

2015 ◽

Vol 74 (Suppl 2) ◽

pp. 1241.2-1241

Author(s):

T. Giani ◽

L. Capirchio ◽

A. Marino ◽

F. Bertini ◽

A. Mauro ◽

...

Keyword(s):

Differential Diagnosis ◽

Chronic Recurrent Multifocal Osteomyelitis ◽

Multifocal Osteomyelitis

Download Full-text

Clinical and Diagnostic Considerations for Atypical, Adult Onset Presentation of Chronic Recurrent Multifocal Osteomyelitis (CRMO)

Case Reports in Rheumatology ◽

10.1155/2019/8206892 ◽

2019 ◽

Vol 2019 ◽

pp. 1-8

Author(s):

Stacey Mahady ◽

Amit Ladani

Keyword(s):

Bone Biopsy ◽

Delayed Diagnosis ◽

Chronic Recurrent Multifocal Osteomyelitis ◽

The Elderly ◽

Severe Form ◽

X Rays ◽

Elderly Age ◽

Bony Lesions ◽

Multifocal Osteomyelitis ◽

One Year

Chronic recurrent multifocal osteomyelitis (CRMO) is the most severe form of chronic nonbacterial osteomyelitis (CNO) and is a rare autoinflammatory bone disorder that mostly affects children and adolescents. CRMO is a diagnosis of exclusion, resulting in often-delayed diagnosis with over one year on average from onset of symptoms to time of diagnosis. Initial diagnosis is rare in adults and previously undocumented in the elderly (age greater than 65). We highlight a case of a 74-year-old elderly Caucasian female with a history of palmoplantar pustular psoriasis who presented with pelvic and hip pain. Imaging findings included multiple bony lesions on x-rays, increased uptake in the left side of the pelvis, ileum, proximal sternum, and bilateral medial clavicles on nuclear bone scan. Bone biopsy histologic results of marrow fibrosis and plasma cell infiltrate indicative of chronic inflammation lead to the diagnosis of CRMO. This case highlights that while CRMO is typically a disease with childhood onset, it, while rare, can also present in adults and now has presented in the elderly, remaining an important part of the differential diagnosis of bone pain in adults and the elderly in addition to infectious osteomyelitis and malignancy when imaging reveals multiple bony lesions. This in turn will facilitate the reduction of unnecessary medical treatment and antibiotics.

Download Full-text