scholarly journals SAT0382 Changes in volumetric bone mineral density and bone microarchitecture in patients with ankylosing spondylitis. a five-year prospective study using hrpqct

2017 ◽  
Author(s):  
A Deminger ◽  
E Klingberg ◽  
M Lorentzon ◽  
H Carlsten ◽  
LT Jacobsson ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Ankylosing Spondylitis ◽  
Prospective Study ◽  
Bone Mineral ◽  
Bone Microarchitecture ◽  
Volumetric Bone Mineral Density ◽  
Mineral Density

scholarly journals Bone Mineral Density and Bone Microarchitecture in a Cohort of Patients with Erdheim-Chester Disease

2020 ◽  
Author(s):  
Tianhua He ◽  
Lijia Cui ◽  
Na Niu ◽  
Fengdan Wang ◽  
Huilei Miao ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Bone Microarchitecture ◽  
Volumetric Bone Mineral Density ◽  
Mineral Density ◽  
Erdheim Chester Disease ◽  
Volumetric Bmd ◽  
Normal Mean ◽  
Erdheim Chester ◽  
Chester Disease

Abstract Background: Erdheim-Chester Disease (ECD) is a rare type of non-Langerhans histiocytosis. Skeletal structures are affected in over 95% ECD patients. Due to the lack of proper imaging assessment tools, the alteration of bone microarchitecture in ECD has not been well studied. High-resolution peripheral quantitative computed tomography (HR-pQCT) is a newly developed assessment of bone mineral density and bone microarchitecture.Methods: We performed a cross-sectional study with thirteen patients diagnosed with ECD in Peking Union Medical College Hospital between October 2018 and June 2019. The diagnosis of ECD was based on typical pathological findings in the context of appropriate clinical and radiological manifestations. Bone geometry, volumetric bone mineral density and bone microarchitecture of those ECD patients were assessed using HR-pQCT at the non-dominant distal radius and distal tibia. Those HR-pQCT parameters were then compared to an ongoing population-based database of HR-pQCT for Mainland Chinese.Results: As a result, remarkable heterogeneity of osteosclerosis in HR-pQCT images was found in ECD patients, ranging from apparently normal structure, scattered thickening of trabecula, to homogenous consolidation. On quantitative measurements, total volumetric BMD (383.50mg/cm3, 1.352 times of normal mean, p=0.023) of the tibia differed significantly in ECD patients, attributing to the increased trabecular volumetric BMD (291 mg/cm3, 2.058 times of normal mean, p=0.003). The increased trabecular volumetric BMD of tibia was associated with remarkably increased number of trabecula (1.7/mm, 1.455 times of normal mean, p=0.002) and increased thickness of trabecula (0.37mm, 1.466 times of normal mean, p=0.003). These differences could be due to the existence of dense bone interposed in the trabecula.Conclusion: This study is the first to assess the volumetric bone mineral density and bone microstructure with HR-pQCT in a cohort of ECD patients, and indicated that the application of HR-pQCT may help to reveal the nature of bone lesions in the disease.

scholarly journals Bone Mineral Density and Bone Microarchitecture in a Cohort of Patients with Erdheim-Chester Disease

2020 ◽  
Author(s):  
Tianhua He ◽  
Lijia Cui ◽  
Na Niu ◽  
Fengdan Wang ◽  
Huilei Miao ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Bone Microarchitecture ◽  
Volumetric Bone Mineral Density ◽  
Mineral Density ◽  
Erdheim Chester Disease ◽  
Volumetric Bmd ◽  
Normal Mean ◽  
Erdheim Chester ◽  
Chester Disease

Abstract Background: Erdheim-Chester Disease (ECD) is a rare type of non-Langerhans histiocytosis. Skeletal structures are affected in over 95% ECD patients. Due to the lack of proper imaging assessment tools, the alteration of bone microarchitecture in ECD has not been well studied. High-resolution peripheral quantitative computed tomography (HR-pQCT) is a newly developed assessment of bone mineral density and bone microarchitecture. Methods: We performed a cross-sectional study with thirteen patients diagnosed with ECD in Peking Union Medical College Hospital between October 2018 and June 2019. The diagnosis of ECD was based on typical pathological findings in the context of appropriate clinical and radiological manifestations. Bone geometry, volumetric bone mineral density and bone microarchitecture of those ECD patients were assessed using HR-pQCT at the non-dominant distal radius and distal tibia. Those HR-pQCT parameters were then compared to an ongoing population-based database of HR-pQCT for Mainland Chinese. Results: As a result, remarkable heterogeneity of osteosclerosis in the HR-pQCT images was found in ECD patients, ranging from apparent normal structure, scattered thickening of trabecula, to homogenous consolidation. In terms of quantitative measurements, total volumetric BMD (383.50mg/cm3, 1.352 times of normal mean, p=0.023) of the tibia differed significantly in ECD patients, due to the increased trabecular volumetric BMD (291 mg/cm3, 2.058 times of normal mean, p=0.003). The increased trabecular volumetric BMD of tibia was associated with remarkably increased number of trabecula (1.7/mm, 1.455 times of normal mean, p=0.002) and increased thickness of trabecula (0.37mm, 1.466 times of normal mean, p=0.003). These differences could be due to the existence of dense bone interposed in the trabecula. Conclusion: This study is the first to assess the volumetric bone mineral density and bone microstructure with HR-pQCT in a cohort of ECD patients and indicated that the application of HR-pQCT may help to reveal the nature of bone lesions in the disease.

scholarly journals The correlation between volumetric bone mineral density and morphological parameters of the proximal femur and clinical outcomes in ankylosing spondylitis patients with hip involvement

2022 ◽  
Vol 23 (1) ◽  
Author(s):  
Xinfeng Wu ◽  
Liang Zhang ◽  
Tao Bian ◽  
Siliang Man ◽  
Hongchao Li ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Ankylosing Spondylitis ◽  
Femoral Neck ◽  
Bone Mineral ◽  
Proximal Femur ◽  
Volumetric Bone Mineral Density ◽  
Morphological Parameters ◽  
Mineral Density ◽  
T Score ◽  
Group A

Abstract Background To measure volumetric bone mineral density (vBMD) with quantitative computed tomography (QCT) in the proximal femur of ankylosing spondylitis (AS) patients with hip involvement and analyze their correlations with radiographic and clinical parameters. Methods Sixty-five AS inpatients were enrolled in this study. The bone mineral density was measured by QCT and dual-energy x-ray absorptiometry (DXA), respectively. The morphological parameters of the proximal femur were measured on digital anteroposterior (AP) radiographs of the pelvis. The correlations between them were analyzed by SPSS software. Results The average trabecular vBMD measured at the femoral neck was 136.38 ± 25.58 mg/cm3. According to the BASRI-Hip score, group A consisted of 39 hips (0–2 score) and group B consisted of 26 hips (3–4 score). There were significant differences regarding trabecular CTXA equivalent T-score between group A and B at the femoral neck (p = 0.004); intertrochanteric region (p < 0.001) and greater trochanter (p = 0.001). The trabecular CTXA equivalent T-score at femoral neck had a negative correlation with disease duration (r = − 0.311, p = 0.012) and with CBR (r = − 0.319, p = 0.010). Conclusions The low trabecular bone density at the site of the hip was associated with the duration of disease progression and degree of hip involvement. Meanwhile, it had a correlation with hip function status although we failed to confirm a significant relationship between hip vBMD and disease activity.

scholarly journals Bone microarchitecture in ankylosing spondylitis and the association with bone mineral density, fractures, and syndesmophytes

2013 ◽  
Vol 15 (6) ◽  
pp. R179 ◽  
Author(s):  
Eva Klingberg ◽  
Mattias Lorentzon ◽  
Jan Göthlin ◽  
Dan Mellström ◽  
Mats Geijer ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Ankylosing Spondylitis ◽  
Bone Mineral ◽  
Bone Microarchitecture ◽  
Mineral Density
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