scholarly journals AB0227 Transcriptional profiling of synovial macrophages using minimally invasive ultrasound-guided synovial biopsies in rheumatoid arthritis

2018 ◽  
Author(s):  
H. Perlman ◽  
Keyword(s):  
Rheumatoid Arthritis ◽  
Minimally Invasive ◽  
Transcriptional Profiling ◽  
Ultrasound Guided

scholarly journals Transcriptional Profiling of Synovial Macrophages Using Minimally Invasive Ultrasound-Guided Synovial Biopsies in Rheumatoid Arthritis

2018 ◽  
Vol 70 (6) ◽  
pp. 841-854 ◽  
Author(s):  
Arthur M. Mandelin ◽  
Philip J. Homan ◽  
Alexander M. Shaffer ◽  
Carla M. Cuda ◽  
Salina T. Dominguez ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Minimally Invasive ◽  
Transcriptional Profiling ◽  
Ultrasound Guided

scholarly journals Common Transcriptomic Effects of Abatacept and Other DMARDs on Rheumatoid Arthritis Synovial Tissue

2021 ◽  
Vol 12 ◽  
Author(s):  
Clement Triaille ◽  
Patrick Durez ◽  
Tatiana Sokolova ◽  
Gaëlle Tilman ◽  
Laurent Méric de Bellefon ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Synovial Tissue ◽  
Gene Expression Analysis ◽  
Transcriptional Profiling ◽  
Published Data ◽  
Leukocyte Activation ◽  
Ultrasound Guided ◽  
Paraffin Sections ◽  
Activation Pathways ◽  
Pathway Analyses

ObjectivesOur goal was to assess for the histological and transcriptomic effects of abatacept on RA synovia, and to compare them with previously published data from four other DMARDs: tocilizumab, rituximab, methotrexate, and adalimumab.MethodsSynovial tissue was obtained using ultrasound-guided biopsy from affected joints of 14 patients, before and 16 weeks after treatment with subcutaneous abatacept 125 mg weekly. Paraffin-sections were stained and scored for CD3+, CD20+, and CD68+ cell infiltration. Transcriptional profiling was performed using GeneChip Human Genome U133 Plus 2.0 arrays (Affymetrix) and analyzed on Genespring GX (Agilent). Pathway analyses were performed on Genespring GX, Metascape, and EnrichR.ResultsGene expression analysis identified 304 transcripts modulated by abatacept in synovial tissue. Downregulated genes were significantly enriched for immune processes, strongly overlapping with our findings on other therapies. Data were pooled across these studies, revealing that genes downregulated by DMARDs are significantly enriched for both T-cell and myeloid leukocyte activation pathways. Interestingly, DMARDs seem to have coordinate effects on the two pathways, with a stronger impact in good responders to therapy as compared to moderate and non-responders.ConclusionWe provide evidence that the effects of five DMARDs on the RA synovium culminate in the same pathways. This confirms previous studies suggesting the existence of common mediators downstream of DMARDs, independent of their primary targets.

Study on Clinical Application of Different Ultrasound-Guided Planar Techniques in Minimally Invasive Percutaneous Nephrolithotomy

2021 ◽  
pp. 155335062199779
Author(s):  
Difu Fan ◽  
Leming Song ◽  
Monong Li ◽  
Chunxiang Luo ◽  
Xiaohui Liao ◽  
...  
Keyword(s):  
Minimally Invasive ◽  
Real Time ◽  
Clinical Application ◽  
Short Axis ◽  
Ultrasound Guided ◽  
Out Of Plane ◽  
Minimally Invasive Percutaneous Nephrolithotomy ◽  
Plane Group ◽  
Plane Technique ◽  
Guided Puncture

Objective. The objective is to explore the clinical application value of ultrasound long- and short-axis planar technology in real-time guided puncture in minimally invasive percutaneous nephrology. Methods. The clinical data of 80 patients undergoing real-time ultrasound-guided minimally invasive percutaneous nephrolithotomy from September 2018 to October 2019 were analyzed. The patients were randomly divided into 2 groups with different ultrasound-guided puncture techniques, long-axis in-plane technique and short-axis out-of-plane technique. Results. Minimally invasive percutaneous nephrolithotomies under real-time ultrasound guidance were successfully completed in both groups of patients. The success rate of the first puncture in the short-axis out-of-plane group was significantly higher than that in the long-axis in-plane group, and the differences were statistically significant ( P <.05); the total puncture time in the short-axis out-of-plane group was significantly less than the long-axis in-plane group, and the differences were statistical significance ( P <.05); there was no significant difference in the single-stage stone removal rate, total percutaneous renal channels, total hospital stay, and rate of complications by the Clavien classification between the 2 groups ( P > .05). Conclusion. Ultrasound long-axis and short-axis planar technologies can achieve good clinical application results in real-time guided puncture to establish percutaneous renal channels during minimally invasive percutaneous nephrolithotomy. Compared with the long-axis in-plane technique, the short-axis out-of-plane technique can shorten the puncture time and improve the success rate of the first puncture.

scholarly journals SARS- CoV-2 INFECTION ASSOCIATED WITH MONOCLONAL GAMMOPATHY. A CASE REPORT BASED ON THE STUDY OF MINIMALLY INVASIVE ULTRASOUND-GUIDED AUTOPSY

2021 ◽  
Author(s):  
González-García MªCarmen ◽  
Pérez Montero Pablo ◽  
Pena Burgos Eva Manuela ◽  
Vega Cabrera Cristina ◽  
Hernández Cabrero Teresa ◽  
...  
Keyword(s):  
Case Report ◽  
Minimally Invasive ◽  
Monoclonal Gammopathy ◽  
Ultrasound Guided

Ultrasound-guided minimally invasive grinding for clearing blood clots: promises and challenges

2018 ◽  
Vol 21 (2) ◽  
pp. 10-14 ◽  
Author(s):  
Dalia Mahdy ◽  
Ramez Reda ◽  
Nabila Hamdi ◽  
Islam S.M. Khalil
Keyword(s):  
Minimally Invasive ◽  
Ultrasound Guided ◽  
Blood Clots

Surgical Improvement of Breast Abscess in Lactating Mothers

2021 ◽  
Vol 15 (10) ◽  
pp. 3450-3451
Author(s):  
Khenpal Das ◽  
Jabeen Atta ◽  
Zubair Yousfani ◽  
Sajida Asghar ◽  
Ghullamullah Rind ◽  
...  
Keyword(s):  
Minimally Invasive ◽  
Fine Needle Aspiration ◽  
Needle Aspiration ◽  
Minimally Invasive Procedures ◽  
Invasive Procedures ◽  
Ultrasound Guided ◽  
Fine Needle ◽  
Lactating Mothers ◽  
Operative Recovery ◽  
Puerperal Mastitis

Objective: To examine the overall diagnostic and the surgical outcomes among lactating females of breast abscesses who were treated using minimally invasive procedures. Methods: This descriptive case series study was conducted during the seven months from May 2019 to November 2019. At the general surgery department of Liaquat University of Medical & Health Sciences, Jamshoro, treated 60 lactating female patients with probable breast abscesses, with an age of more than 18 years. Percutaneous drainage insertion and ultrasound guided fine needle aspiration (FNA) were used in the treatment of breast abscesses in a minimally invasive manner. Ultrasound-guided fine needle aspiration was performed during drainage installation, followed by the insertion percutaneously of the ordinary drainage catheter through a prick incision. Data was collected by study proforma and SPSS version 20 was used for the analysis of data. Results: Average age of the females was 40 years. Clinical inflammation like puerperal mastitis was in 24(40%) patients, non-puerperal mastitis was in 27(45%) of the cases and other inflammation like as folliculinids and infected seroma were in 9(15%) patients. Fibrocystic variation was seen in 58 percent of the participants. 67 percent of non-puerperal mastitis patients had fibrocystic variations, 17 percent of puerperal mastitis patients had fibrocystic variations, and 56 percent of the other patients with other inflammatory forms had fibrocystic variations. Early problems occurred in 12 of every 60 patients (20%) whose are treated using minimally invasive procedures. Conclusion: As per study conclusion, fine needle aspiration (FNA) as per ultrasound guidance minimally invasive therapy combined with antibiotic treatment was observed to be the effective treatment approach for breast abscesses, and it is also a feasible and safe in terms of less post-operative recovery duration, complications, and hospital stay. Keywords: lactating mothers, Abscess, breast, surgery

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