AbstractAssociation between vitamin D and uric acid is complex and might be
bidirectional. Our study aimed to determine the bidirectional association
between vitamin D and uric acid in adults. Using MEDLINE via PubMed and Scopus,
we systematically searched for observational or interventional studies in
adults, which assessed the association between serum vitamin D and serum uric
acid, extracted the data, and conducted analysis by direct and network
meta-analysis. The present review included 32 studies, of which 21 had vitamin D
as outcome and 11 had uric acid as outcome. Meta-analysis showed a significant
pooled beta coefficient of serum uric acid level on serum 25(OH)D level from 3
studies of 0.512 (95% confidence interval: 0.199, 0.825) and a
significant pooled odds ratio between vitamin D deficiency and hyperuricemia of
1.496 (1.141, 1.963). The pooled mean difference of serum 25(OH)D between groups
with hyperuricemia and normouricemia was non-significant at 0.138
(−0.430, 0.707) ng/ml, and the pooled mean difference of serum
uric acid between categories of 25(OH)D were also non-significant at 0.072
(−0.153, 0.298) mg/dl between deficiency and normal, 0.038
(−0.216, 0.292) mg/dl between insufficiency and normal, and
0.034 (−0.216, 0.283) mg/dl between deficiency and
insufficiency. In conclusion, increasing serum uric acid might be associated
with increasing 25(OH)D level, while vitamin D deficiency is associated with
hyperuricemia. These reverse relationships should be further evaluated in a
longitudinal study.
Serum uric acid and incident atrial fibrillation: A systematic review and dose–response meta‐analysis
