scholarly journals FRI0182 RISK FACTORS ASSOCIATED WITH RENAL INVOLVEMENT IN PRIMARY SJÖGREN’S SYNDROME: DATA FROM THE SPANISH SJÖGRENSER COHORT

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 674.3-675
Author(s):  
J. Narváez ◽  
C. Sánchez-Piedra ◽  
M. Fernandez Castro ◽  
V. Martinez Taboada ◽  
A. Olive ◽  
...  
Keyword(s):  
Risk Factors ◽  
Renal Disease ◽  
Disease Activity ◽  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Renal Involvement ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Primary Sjögren’S Syndrome ◽  
Sjögren‘S Syndrome

Objectives:To investigate the prevalence, risk factors, and effects of primary renal disease on morbidity and mortality in patients with primary Sjögren’s syndrome (pSS).Methods:All patients in the SJÖGRENSER (registry of adult SSp patients of the Spanish Society of Rheumatology, cross-sectional phase) cohort were retrospectively investigated for the presence of clinically significant renal involvement directly related to pSS activity.Results:Of the 437 patients investigated, 39 (9%) presented overt renal involvement during follow-up. Severe renal disease necessitating kidney biopsy was relatively rare (23%).Renal involvement may complicate pSS at any time during the disease course and is associated with severe disease (indicated by higher scores of involvement, activity, and damage), systemic multiorgan involvement, and a higher frequency of lymphoma. Multivariate analysis showed that older age (odds ratio [OR] 1.03, 95% confidence interval [CI] 1.00–1.07), higher European League Against Rheumatism Sjogren’s Syndrome Disease Activity Index scores (OR 1.1, CI 1.03–1.18), serum anti-La/SSB positivity (OR 6.44, CI 1.36–30.37), and non-vasculitic cutaneous involvement (OR 8.64, 1.33–55.90) were independently associated with this complication.Chronic renal failure developed in 23 of 39 patients (59%); only 1 of them progressed to end-stage renal disease necessitating renal replacement therapy. Patients with renal disease showed higher Sjögren’s syndrome disease damage index scores (SSDDI), higher rates of hospitalization due to disease activity and higher rates of clinically relevant comorbidities.Conclusion:Renal involvement is an uncommon complication in pSS that was observed in 9% of patients. Although categorized as a non-negligible comorbidity, this condition shows a favorable prognosis.Disclosure of Interests:None declared

scholarly journals Renal Involvement In Primary Sjögren’s Syndrome: Data From The Spanish Sjögrenser Cohort.

2020 ◽  
Author(s):  
Javier Narvaez ◽  
Carlos Sánchez-Piedra ◽  
Mónica Fernández-Castro ◽  
Víctor Martínez-Taboada ◽  
Alejando Olivé ◽  
...  
Keyword(s):  
Renal Disease ◽  
Disease Activity ◽  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Renal Involvement ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Primary Sjögren’S Syndrome ◽  
Primary Sjogren’S Syndrome ◽  
Sjögren‘S Syndrome

Abstract Objectives To investigate the prevalence, associated factors, and effects of primary renal disease on morbidity in patients with primary Sjögren’s syndrome (pSS).Methods All patients in the SJÖGRENSER (registry of adult SSp patients of the Spanish Society of Rheumatology) cohort were retrospectively investigated for the presence of clinically significant renal involvement directly related to pSS activity.Results Of the 437 patients investigated, 39 (9%) presented overt renal involvement during follow-up. Severe renal disease necessitating kidney biopsy was relatively rare (23%). Renal involvement may complicate pSS at any time during the disease course and is associated with severe disease (indicated by higher scores of involvement, activity, and damage), systemic multiorgan involvement, and a higher frequency of lymphoma. Multivariate analysis showed that older age (odds ratio [OR] 1.03, 95% confidence interval [CI] 1.00–1.07), higher European League Against Rheumatism Sjogren’s Syndrome Disease Activity Index scores (OR 1.1, CI 1.03–1.18), serum anti-La/SSB positivity (OR 6.65, CI 1.41–31.372), and non-vasculitic cutaneous involvement (OR 5.47, 1.03–29.02) were independently associated with this complication. Chronic renal failure developed in 23 of 39 patients (59%); only 1 of them progressed to end-stage renal disease necessitating renal replacement therapy. Patients with renal disease showed higher Sjögren’s syndrome disease damage index scores, higher rates of hospitalization due to disease activity and higher rates of clinically relevant comorbidities.Conclusion Renal involvement is an uncommon complication in pSS that was observed in 9% of patients. Although categorized as a non-negligible comorbidity, this condition shows a favorable prognosis.

scholarly journals The Association of Hypocomplementemia With Disease Activity in Patients With Primary Sjogren's Syndrome

2021 ◽  
Author(s):  
Wei Lin ◽  
Zhifei Xin ◽  
Jialan Wang ◽  
Yixuan Liu ◽  
Xiuying Ren ◽  
...  
Keyword(s):  
Risk Factors ◽  
Nervous System ◽  
Disease Activity ◽  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Primary Sjögren’S Syndrome ◽  
System Involvement ◽  
Sjögren‘S Syndrome

Abstract We assessed the prevalence of hypocomplementemia (HC), possible risk factors, and its prognosis in patients with primary Sjögren’s syndrome (pSS). The data of 84 patients with HC admitted in Hebei General Hospital were retrospectively analyzed and compared to data of patients with normocomplementemic (NC). Logistic regression analysis was used to detect risk factors. The presence of hyper-immunoglobulin G (IgG) and anti-Ro52 was significantly higher in patients with HC. The patients with pSS with HC had higher hematologic, renal, and nervous system involvement and The European League Against Rheumatism Sjögren’s Syndrome Disease Activity Index score (p < 0.05) and received more immunosuppressant treatments than those with NC (p < 0.05). Multivariate logistic analysis indicated that renal involvement (odds ratio [OR] = 4.09), nervous system involvement (OR = 3.82), leukopenia (OR = 2.57), and hyper-IgG (OR = 3.34) were independent risk factors for pSS with HC. Thus, HC was not an uncommon manifestation of pSS and was associated with leukocytopenia, renal and nervous system involvement, and severe disease activity. HC occurred in younger and short-term patients with pSS. Those with pSS-HC had an increased possibility to develop systemic lupus erythematosus. Such patients have distinctive clinical manifestations and worse prognosis that require extensive treatments.

scholarly journals RENAL INVOLVEMENT IN PRIMARY SJOGREN’S SYNDROME (CASE REPORT)

2021 ◽  
Vol 19 (5) ◽  
pp. 550-556
Author(s):  
E. S. Ausianik ◽  
◽  
A. M. Zhigaltsov ◽  
V. S. Luchko ◽  
◽  
...  
Keyword(s):  
Sjögren’S Syndrome ◽  
Clinical Case ◽  
Sjögren's Syndrome ◽  
Renal Involvement ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Primary Sjögren’S Syndrome ◽  
Primary Sjogren’S Syndrome ◽  
Primary Sjögren's Syndrome ◽  
Sjögren‘S Syndrome

This article presents a clinical case of primary Sjogren's syndrome with a detailed description of the clinical and laboratory dynamics of the disease and its extraglandular manifestations based on the analysis of the data obtained during the patient's hospitalizations in the rheumatology department of the Grodno University Clinic in the period from March 2018 to June 2021.

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