PC.64 Audit of the Management and follow up of infants who received Therapeutic Hypothermia for Neonatal Encephalopathy in NHS Greater Glasgow and Clyde (GG&C) from January 2008 to December 2010

2014 ◽  
Vol 99 (Suppl 1) ◽  
pp. A58.2-A58
Author(s):  
N Smee ◽  
H Moss ◽  
J Gibson ◽  
L Jackson
Keyword(s):  
Therapeutic Hypothermia ◽  
Neonatal Encephalopathy

scholarly journals Early exit from neonatal therapeutic hypothermia: A single institution experience using MRI to guide decision-making

2020 ◽  
Vol 13 (4) ◽  
pp. 441-447
Author(s):  
Y.N. White ◽  
P.E. Grant ◽  
J.S. Soul ◽  
T. Inder ◽  
M. El-Dib
Keyword(s):  
Therapeutic Hypothermia ◽  
Chart Review ◽  
Retrospective Chart Review ◽  
Outcome Data ◽  
Neonatal Encephalopathy ◽  
Early Exit ◽  
Treatment Groups ◽  
Magnetic Resonance Imaging Mri ◽  
Electroencephalogram Eeg

BACKGROUND: To evaluate the feasibility of a protocol using combined magnetic resonance imaging (MRI), clinical data, and electroencephalogram (EEG) to identify neonates with mild neonatal encephalopathy (NE) treated with therapeutic hypothermia (TH) who are eligible for “early exit”. METHODS: Retrospective chart review of TH cases at a single Level III NICU over a 5-year period was used to describe the demographic, clinical, and outcome data in neonates that received early exit in contrast to 72 hour TH treatment. RESULTS: Two hundred and eight TH cases, including 18 early exit cases (9%) and 9 cases (4%) evaluated for early exit with MRI but continued on 72 hours of TH, were identified. Early exit and 72 hour treatment groups did not differ in demographics or cord gas measures, although early exit neonates had a shorter length of stay (p < 0.05). Consistent with the early exit protocol, no early exit infants had evidence of moderate or severe encephalopathy on EEG or evidence of hypoxic ischemic injury on MRI at 24 hours of life. Neurology follow up between age 1 and 18 months was available for 10 early exit infants, 8 of whom had a normal examination. CONCLUSIONS: Early MRI at 24 hours of age, alongside clinical and EEG criteria, is feasible as part of a protocol to identify neonates eligible for early exit from therapeutic hypothermia.

Management of Comfort and Sedation in Neonates with Neonatal Encephalopathy Treated with Therapeutic Hypothermia

2021 ◽  
pp. 101264
Author(s):  
Christopher McPherson ◽  
Adam Frymoyer ◽  
Cynthia M. Ortinau ◽  
Steven P. Miller ◽  
Floris Groenendaal
Keyword(s):  
Therapeutic Hypothermia ◽  
Neonatal Encephalopathy

Therapeutic Hypothermia in Brazil: A MultiProfessional National Survey

2018 ◽  
Vol 36 (11) ◽  
pp. 1150-1156 ◽  
Author(s):  
G. F. Variane ◽  
L. M. Cunha ◽  
P. Pinto ◽  
P. Brandao ◽  
R. S. Mascaretti ◽  
...  
Keyword(s):  
Therapeutic Hypothermia ◽  
National Survey ◽  
Health Care Professionals ◽  
Brain Magnetic Resonance Imaging ◽  
Significant Heterogeneity ◽  
Online Questionnaire ◽  
Cross Sectional ◽  
Long Term Follow Up ◽  
Magnetic Resonance Imaging Mri

Objective To determine the rate of therapeutic hypothermia (TH) use, current practices, and long-term follow-up. Study Design Prospective cross-sectional national survey with 19 questions related to the assessment of hypoxic–ischemic encephalopathy (HIE) and TH practices. An online questionnaire was made available to health care professionals working in neonatal care in Brazil. Results A total of 1,092 professionals replied, of which 681 (62%) reported using TH in their units. Of these, 624 (92%) provided TH practices details: 136 (20%) did not use any neurologic score or amplitude-integrated electroencephalogram (aEEG) to assess encephalopathy and 81(13%) did not answer this question. Any specific training for encephalopathy assessment was provided to only 81/407 (19%) professionals. Infants with mild HIE are cooled according to 184 (29%) of the respondents. Significant variations in practice were noticed concerning time of initiation and cooling methods, site of temperature measurements and monitoring, and access to aEEG, electroencephalogram (EEG), and neurology consultation. Only 19% could perform a brain magnetic resonance imaging (MRI), and 31% reported having a well-established follow-up program for these infants. Conclusion TH has been implemented in Brazil but with significant heterogeneity for most aspects of hypothermia practices, which may affect safety or efficacy of the therapy. A step forward toward quality improvement is important.

scholarly journals Cost-Effectiveness of Therapeutic Hypothermia to Treat Neonatal Encephalopathy

2010 ◽  
Vol 13 (6) ◽  
pp. 695-702 ◽  
Author(s):  
Dean A. Regier ◽  
Stavros Petrou ◽  
Jane Henderson ◽  
Oya Eddama ◽  
Nishma Patel ◽  
...  
Keyword(s):  
Cost Effectiveness ◽  
Therapeutic Hypothermia ◽  
Neonatal Encephalopathy

Association of cerebral activity with MRI scans in infants with neonatal encephalopathy undergoing therapeutic hypothermia

2019 ◽  
Vol 178 (6) ◽  
pp. 851-861 ◽  
Author(s):  
Eilon Shany ◽  
Nasrin Taha ◽  
Ela Benkovich ◽  
Rosa Novoa ◽  
Irina Meledin ◽  
...  
Keyword(s):  
Therapeutic Hypothermia ◽  
Neonatal Encephalopathy ◽  
Cerebral Activity ◽  
Mri Scans

scholarly journals CRT-500.12 Cost-Effectiveness Analysis of Therapeutic Hypothermia in Critical Patients After Cardiac Arrest: Estimate of Lifetime Horizon Follow-Up

2020 ◽  
Vol 13 (4) ◽  
pp. S44-S45
Author(s):  
Luis Augusto Dallan ◽  
Natali Giannetti ◽  
Thatiane Facholi Polastri ◽  
Antonio Baruzzi ◽  
Gisele Sampaio ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Cost Effectiveness ◽  
Therapeutic Hypothermia ◽  
Cost Effectiveness Analysis ◽  
Lifetime Horizon ◽  
Effectiveness Analysis ◽  
Critical Patients

Therapeutic hypothermia for mild neonatal encephalopathy: a systematic review and meta-analysis

2018 ◽  
Vol 105 (2) ◽  
pp. 225-228 ◽  
Author(s):  
Ujwal Kariholu ◽  
Paolo Montaldo ◽  
Theodora Markati ◽  
Peter J Lally ◽  
Russell Pryce ◽  
...  
Keyword(s):  
Usual Care ◽  
Therapeutic Hypothermia ◽  
Data Extraction ◽  
Meta Analysis ◽  
Adverse Outcomes ◽  
Whole Body ◽  
Current Evidence ◽  
Neonatal Encephalopathy ◽  
Medical Subject Headings ◽  
Manual Search

ObjectivesTo examine if therapeutic hypothermia reduces the composite outcome of death, moderate or severe disability at 18 months or more after mild neonatal encephalopathy (NE).Data sourceMEDLINE, Cochrane database, Scopus and ISI Web of Knowledge databases, using ‘hypoxic ischaemic encephalopathy’, ‘newborn’ and ‘hypothermia’, and ‘clinical trials’ as medical subject headings and terms. Manual search of the reference lists of all eligible articles and major review articles and additional data from the corresponding authors of selected articles.Study selectionRandomised and quasirandomised controlled trials comparing therapeutic hypothermia with usual care.Data extractionSafety and efficacy data extracted independently by two reviewers and analysed.ResultsWe included the data on 117 babies with mild NE inadvertently recruited to five cooling trials (two whole-body cooling and three selective head cooling) of moderate and severe NE, in the meta-analysis. Adverse outcomes occurred in 11/56 (19.6%) of the cooled babies and 12/61 (19.7%) of the usual care babies (risk ratio 1.11 (95% CIs 0.55 to 2.25)).ConclusionsCurrent evidence is insufficient to recommend routine therapeutic hypothermia for babies with mild encephalopathy and significant benefits or harm cannot be excluded.

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