Change in tidal volume during cardiopulmonary resuscitation in newborn piglets

2015 ◽  
Vol 100 (6) ◽  
pp. F530-F533 ◽  
Author(s):  
Elliott S Li ◽  
Po-Yin Cheung ◽  
Megan O'Reilly ◽  
Georg M Schmölzer
Keyword(s):  
Cardiopulmonary Resuscitation ◽  
Tidal Volume ◽  
Newborn Piglets

scholarly journals Asphyxiated Female and Male Newborn Piglets Have Similar Outcomes With Different Cardiopulmonary Resuscitation Interventions

2020 ◽  
Vol 8 ◽  
Author(s):  
Seung Yeon Kim ◽  
Gyu-Hong Shim ◽  
Megan O'Reilly ◽  
Po-Yin Cheung ◽  
Tze-Fun Lee ◽  
...  
Keyword(s):  
Cardiopulmonary Resuscitation ◽  
Cerebral Oxygenation ◽  
Secondary Analysis ◽  
Spontaneous Circulation ◽  
Male And Female ◽  
Newborn Piglets ◽  
Sustained Inflation ◽  
Significant Difference ◽  
Tissue Homogenates ◽  
Males And Females

Background: Male newborns have a greater risk of poor cardiovascular and respiratory outcomes compared to females. The mechanisms associated with the “male disadvantage” remains unclear. We have previously shown no difference between male and female newborn piglets during hypoxia, asphyxia, resuscitation, and post-resuscitation recovery. However, it is unknown if there are differences in resuscitation outcomes between males and females during different cardiopulmonary resuscitation techniques.Intervention and Measurements: Secondary analysis of 184 term newborn mixed breed duroc piglets (1–3 days of age, weighing 2.0 (0.2) kg) from seven different studies, which were exposed to 30–50 min of normocapnic hypoxia followed by asphyxia until asystole. This was followed by cardiopulmonary resuscitation. For the analysis, piglets were divided into male and female groups, as well as resuscitation technique groups (sustained inflation, 3:1 compression-to-ventilation ratio, or asynchronous ventilations during chest compressions). Cardiac function, carotid blood flow, and cerebral oxygenation were continuously recorded throughout the experiment.Main results: Regardless of resuscitation technique, there was no significant difference between males and females in the number achieving return of spontaneous circulation (ROSC) [95/123 (77%) vs. 48/61 (79%)], the time to achieve ROSC [112 (80–185) s vs. 110 (77–186) s], and the 4-h survival rate [81/95 (85%) vs. 40/48 (83%)]. Levels of the injury markers interleukin (IL)−1ß, IL-6, IL-8, and tumor necrosis factor-α in frontoparietal cortex tissue homogenates were similar between males and females.Conclusions: Regardless of resuscitation technique, there was no significant effect of sex on resuscitation outcome, survival, and hemodynamic recovery in asphyxiated newborn piglets.

Comparison of intravenous and endotracheal epinephrine during cardiopulmonary resuscitation in newborn piglets

1999 ◽  
Vol 27 (12) ◽  
pp. 2748-2754 ◽  
Author(s):  
Monica E. Kleinman ◽  
William Oh ◽  
Barbara S. Stonestreet
Keyword(s):  
Cardiopulmonary Resuscitation ◽  
Newborn Piglets

scholarly journals Effects of sustained inflation pressure during neonatal cardiopulmonary resuscitation of asphyxiated piglets

2020 ◽  
Author(s):  
Gyu-Hong Shim ◽  
Seung Yeon Kim ◽  
Po-Yin Cheung ◽  
Tze-Fun Lee ◽  
Megan O’Reilly ◽  
...  
Keyword(s):  
Cardiopulmonary Resuscitation ◽  
Cerebral Oxygenation ◽  
Neonatal Resuscitation ◽  
Spontaneous Circulation ◽  
Control Group ◽  
Inflation Pressure ◽  
Similar Time ◽  
Newborn Piglets ◽  
Arterial Blood ◽  
Sustained Inflation

AbstractObjectiveSustained inflation (SI) during chest compression (CC = CC+SI) significantly reduces time to return of spontaneous circulation (ROSC) compared to 3:1 compression-to-ventilation ratio during neonatal resuscitation. However, the optimal peak inflation pressure (PIP) of SI during CC+SI to improve ROSC and hemodynamic recovery in severely asphyxiated piglets is unknown.AimTo examine if different PIPs of SI during CC+SI will improve ROSC and hemodynamic recovery in severely asphyxiated piglets.Intervention and measurementsTwenty-nine newborn piglets (1-3 days old) were anesthetized, intubated, instrumented and exposed to 30-min normocapnic hypoxia followed by asphyxia. Piglets were randomized into four groups: CC+SI with a PIP of 10 cmH2O (CC+SI_PIP_10, n=8), a PIP of 20 cmH2O (CC+SI_PIP_20, n=8), a PIP of 30 cmH2O (CC+SI_PIP_30, n=8), and a sham-operated control group (n=5). Heart rate, arterial blood pressure, carotid blood flow, cerebral oxygenation, and respiratory parameters were continuously recorded throughout the experiment.Main resultsBaseline parameters were similar between all groups. There was no difference in asphyxiation (duration and degree) between intervention groups. PIP correlated positively with tidal volume and inversely with exhaled CO2 during cardiopulmonary resuscitation. Time to ROSC and rate of ROSC were similar between piglets resuscitated with CC+SI_PIP_10, CC+SI_PIP_20, and CC+SI_PIP_30 cmH2O: median (IQR) 75 (63-193) sec, 94 (78-210) sec, and 85 (70-90) sec; 5/8 (63%), 7/8 (88%), and 3/8 (38%) (p=0.56 and p=0.12, respectively). All piglets that achieved ROSC survived to four hours post-resuscitation. Piglets resuscitated with CC+SI_PIP_30 cmH2O exhibited increased concentrations of pro-inflammatory cytokines interleukin-1β and tumour necrosis factor-α in the frontoparietal cerebral cortex (both p<0.05 vs. sham-operated controls).ConclusionsIn asphyxiated term newborn piglets resuscitated by CC+SI, the use of different PIPs resulted in similar time to ROSC, but PIP at 30 cmH2O showed a larger VT delivery, lower exhaled CO2 and increased tissue inflammatory markers in the brain.

Sustained inflation with 21% versus 100% oxygen during cardiopulmonary resuscitation of asphyxiated newborn piglets - A randomized controlled animal study

Resuscitation ◽  
2020 ◽  
Vol 155 ◽  
pp. 39-47
Author(s):  
Catalina Garcia Hidalgo ◽  
Anne L. Solevag ◽  
Seung Yeun Kim ◽  
Gyu Hong Shim ◽  
Po-Yin Cheung ◽  
...  
Keyword(s):  
Cardiopulmonary Resuscitation ◽  
Animal Study ◽  
Newborn Piglets ◽  
Randomized Controlled ◽  
Sustained Inflation

scholarly journals Web-based Compared to Personal Automated External Defibrillator Assisted Cardiopulmonary Resuscitation Training for Dental Students: Randomized Controlled Trial (Preprint)

2020 ◽  
Author(s):  
Antonia Postina ◽  
Jürgen Hoffmann ◽  
Till Sebastian Mutzbauer
Keyword(s):  
Cardiac Arrest ◽  
Cardiopulmonary Resuscitation ◽  
Tidal Volume ◽  
Chest Compression ◽  
Dental Students ◽  
Basic Knowledge ◽  
Web Based ◽  
The Web ◽  
Personal Tutor

BACKGROUND Cardiopulmonary resuscitation (CPR) is rarely performed by dental staff. The availability of automated external defibrillators (AED) is increasing. Personal tutor training with a manikin is the most common way to teach CPR. But internet-learning approaches, such as video-based teaching, are gaining popularity. OBJECTIVE This pilot study has been designed to compare the performance of CPR after two teaching methods in a simulated cardiac arrest situation. A personal tutor demonstration was compared with a web-based video demonstration. The main hypothesis was that more than 70% of the participants of the tutor-instructed group would start CPR within 10 seconds (s), while only up to 30% of the participants of the web-based video-instructed group would start within this time. METHODS One group of dental students received a 5.5 minutes (min) AED-CPR demonstration by a tutor on a manikin (T-/control group n=23 teams of two). A second group watched a 7min web-based AED-CPR instruction video (W-/intervention group n=23 teams of two). No repetition was offered, no questions or practice allowed. CPR performance was video-recorded and analyzed by two examiners. RESULTS No differences concerning the onset and quality of CPR were found. Students started CPR after detection of cardiac arrest with a minimum delay (median=6s (T)/6s (W); IQR=5/7; P=.52). Tidal volume and chest compression depths were insufficient in both groups (tidal volume: median=14 milliliters (ml) (T)/58ml (W); IQR=218.5/148.5; P=.9; depths: median=30 millimeters (mm) (T)/20mm (W); IQR=12.5/10; P=.02). Tutor-instructed teams compressed deeper, but both groups did not meet the recommended standard. Chest compression rate was in the recommended interval (median=113 (T)/111 compressions/minute (W); IQR=24.5/20; P=.46). More students of the web-based video-instructed group had problems using the AED (T=7 teams; W=14; P=.04) but all except one team continued CPR. They did not focus on the problems with the AED and were able to trigger a shock (T=21 teams; W=19; P=.38). Restart of CPR after the shock within 10s was achieved at almost equal time intervals (median=5s (T)/6s (W); IQR=3/4; P=.54). CONCLUSIONS Dental students can acquire basic knowledge in AED-assisted CPR in similar quality by a short web-based video simulation compared with a short demonstration by a tutor. Contrary to expectations, most parameters of CPR and AED performance quality of web-based video-instructed group were not different to students of the tutor-instructed group. The recommended tidal volume had not been achieved in both groups. Chest compression depth seems to be a parameter that has been more difficult to teach to the web-based video-instructed group. No delays of standard CPR measures were observed after detection of cardiac arrest in both groups. The use of the AED did not distract the attention of the rescuers from the simulated patient. CLINICALTRIAL DRKS00012404

Ultra-low tidal volume ventilation—A novel and effective ventilation strategy during experimental cardiopulmonary resuscitation

Resuscitation ◽  
2018 ◽  
Vol 132 ◽  
pp. 56-62 ◽  
Author(s):  
Robert Ruemmler ◽  
Alexander Ziebart ◽  
Christian Moellmann ◽  
Andreas Garcia-Bardon ◽  
Jens Kamuf ◽  
...  
Keyword(s):  
Cardiopulmonary Resuscitation ◽  
Tidal Volume ◽  
Ventilation Strategy ◽  
Low Tidal Volume ◽  
Low Tidal Volume Ventilation ◽  
Volume Ventilation ◽  
Effective Ventilation

scholarly journals Mouth-to-mouth ventilation through cardiopulmonary resuscitation, is there any other way?

2021 ◽  
Vol 6 (3) ◽  
pp. 066-068
Author(s):  
Maimaitiming Aini ◽  
Wang Xiaohai
Keyword(s):  
Cardiopulmonary Resuscitation ◽  
Tidal Volume ◽  
Ventilation Technique ◽  
Hand Performance

Objective: to provide and explore possibility of new idea that perform mouth-to-mouth ventilation through cardiopulmonary resuscitation. Methods: stage one was establishing the ventilation technique using cola bottles, stage two was measuring the tidal volume when different sized cola bottles were used. Result: the smallest sized cola bottle (500 ml) could also make obvious thorax rise in manikin CPR model. The tidal volume was 174.5 ± 9.1 ml, 220 ± 7.6 ml and 447 ± 15.9 ml respectively for 500 ml, 600 ml and 1.25 L cola bottles when using single hand performance. There were statistical differences (0.001) in tidal volume of different sized cola bottle by using one hand performance and two hands. Conclusion: Larger sized cola bottles (600 ml, 1.25 L) could be used as substitute ventilation technique for mouth-to-mouth ventilation in special circumnutates.

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