scholarly journals 576 A systematic review and meta-analysis of the evidence for association of potential risk factors with deformational plagiocephaly

2021 ◽  
Author(s):  
Christopher Hillyar ◽  
Anjan Nibber ◽  
Juling Ong
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Potential Risk ◽  
Meta Analysis ◽  
Deformational Plagiocephaly ◽  
Potential Risk Factors

scholarly journals Potential risk factors associated with seropositivity for Toxoplasma gondii among pregnant women and HIV infected individuals in Ethiopia: A systematic review and meta-analysis

2020 ◽  
Vol 14 (12) ◽  
pp. e0008944
Author(s):  
Zewdu Seyoum Tarekegn ◽  
Haileyesus Dejene ◽  
Agerie Addisu ◽  
Shimelis Dagnachew
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Toxoplasma Gondii ◽  
Pregnant Women ◽  
Potential Risk ◽  
Meta Analysis ◽  
Published Data ◽  
Factors Associated ◽  
Potential Risk Factors ◽  
Women And Hiv

Background Toxoplasma gondii is an obligate intracellular and neurotropic apicomplexan protozoan parasite infecting almost all warm-blooded vertebrates including humans. To date in Ethiopia, no systematic study has been investigated on the overall effects of potential risk factors associated with seropositivity for Toxoplasma gondii among pregnant women and HIV infected individuals. We intended to determine the potential risk factors (PRFs) associated with seropositivity for Toxoplasma gondii from published data among pregnant women and HIV infected individuals of Ethiopia. Methodology An systematic review of the previous reports was made. We searched PubMed, Science Direct, African Journals Online, and Google Scholar for studies with no restriction on the year of publication. All references were screened independently in duplicate and were included if they presented data on at least two risk factors. Meta-analysis using the random or fixed-effects model was made to calculate the overall effects for each exposure. Results Of the 216 records identified, twenty-four reports met our eligibility criteria, with a total of 6003 individuals (4356 pregnant women and 1647 HIV infected individuals). The pooled prevalences of anti-Toxoplasma gondii antibodies were found at 72.5% (95% CI: 58.7% - 83.1%) in pregnant women and 85.7% (95% CI: 76.3% - 91.8%) in HIV infected individuals. A significant overall effect of anti-Toxoplasma gondii seropositivity among pregnant women (p < 0.05) was witnessed with age, abortion history, contact with cats, cat ownership, having knowledge about toxoplasmosis, being a housewife and having unsafe water source. Age, cat ownership, and raw meat consumption were also shown a significant effect (p < 0.05) to anti-Toxoplasma gondii seropositivity among HIV infected individuals. Conclusions This review showed gaps and drawbacks in the earlier studies that are useful to keep in mind to design accurate investigations in the future. The pooled prevalence of anti-Toxoplasma gondii antibodies was found to be higher among pregnant women and HIV infected individuals. This suggests that thousands of immunocompromised individuals (pregnant women and HIV infected patients) are at risk of toxoplasmosis due to the sociocultural and living standards of the communities of Ethiopia. Appropriate preventive measures are needed to reduce the exposure to Toxoplasma gondii infection. Further studies to investigate important risk factors are recommended to support the development of more cost-effective preventive strategies.

scholarly journals Prognosis and Risk Factors for Malignant Peripheral Nerve Sheath Tumor: A Systematic Review and Meta-analysis

2020 ◽  
Author(s):  
Zhenyu Cai ◽  
Xiaodong Tang ◽  
Haijie Liang ◽  
Rongli Yang ◽  
Taiqiang Yan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Potential Risk ◽  
Protective Factor ◽  
Meta Analysis ◽  
Nerve Sheath Tumor ◽  
Pooled Data ◽  
Large Size ◽  
Potential Risk Factors ◽  
Malignant Grade

Abstract Background: No available meta-analysis was printed to systematically introduce the MPNST clinic outcome and risk factors based on largely pooled data. This systematic review and meta-analysis aimed to investigate 5-year OS rate, 5-year EFS rate and LR rate for MPNST, and to assess potential risk factors for prognosis.Methods: Electronic articles published between January 1, 1966 and February 29, 2020, were searched and critically evaluated. The authors independently reviewed the abstracts and extracted data for 5-year OS rate, 5-year EFS rate, LR rate, and potential risk factors for prognosis.Results: Twenty-eight literatures were finally included for meta-analysis. The pooled 5-year OS rate, 5-year EFS rate, and LR rate were 49%, 37%, and 38%, respectively. The significant prognostic factors for survival were NF1 status, tumor size, depth, location, malignant grade, margin status, chemotherapy, and radiotherapy. Age and sex were not associated with survival.Conclusion: Survival and local recurrence of MPNST are poor. Worse prognosis is mainly associated with NF 1, large size, deep to fascia, high grade, metastases and location (trunk and head & neck). Complete resection with adequate surgical margins is the mainstay protective factor of MPNST patients, following necessary adjuvant therapies.

scholarly journals Potential risk factors associated with human alveolar echinococcosis: Systematic review and meta-analysis

2017 ◽  
Vol 11 (7) ◽  
pp. e0005801 ◽  
Author(s):  
Franz J. Conraths ◽  
Carolina Probst ◽  
Alessia Possenti ◽  
Belgees Boufana ◽  
Rosella Saulle ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Potential Risk ◽  
Alveolar Echinococcosis ◽  
Meta Analysis ◽  
Factors Associated ◽  
Potential Risk Factors

scholarly journals Potential Risk Factors Associated with Human Cystic Echinococcosis: Systematic Review and Meta-analysis

2016 ◽  
Vol 10 (11) ◽  
pp. e0005114 ◽  
Author(s):  
Alessia Possenti ◽  
Raúl Manzano-Román ◽  
Carlos Sánchez-Ovejero ◽  
Belgees Boufana ◽  
Giuseppe La Torre ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Potential Risk ◽  
Cystic Echinococcosis ◽  
Meta Analysis ◽  
Factors Associated ◽  
Potential Risk Factors ◽  
Human Cystic Echinococcosis

scholarly journals Prognosis and Risk Factors for Malignant Peripheral Nerve Sheath Tumor: A Systematic Review and Meta-analysis

2020 ◽  
Author(s):  
Zhenyu Cai ◽  
Xiaodong Tang ◽  
Haijie Liang ◽  
Rongli Yang ◽  
Taiqiang Yan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Potential Risk ◽  
Protective Factor ◽  
Meta Analysis ◽  
Nerve Sheath Tumor ◽  
Pooled Data ◽  
Large Size ◽  
Potential Risk Factors ◽  
Malignant Grade

Abstract Background: No available meta-analysis was printed to systematically introduce the MPNST clinic outcome and risk factors based on largely pooled data. This systematic review and meta-analysis aimed to investigate 5-year OS rate, 5-year EFS rate and LR rate for MPNST, and to assess potential risk factors for prognosis.Methods: Electronic articles published between January 1, 1966 and February 29, 2020, were searched and critically evaluated. The authors independently reviewed the abstracts and extracted data for 5-year OS rate, 5-year EFS rate, LR rate, and potential risk factors for prognosis.Results: Twenty-eight literatures were finally included for meta-analysis. The pooled 5-year OS rate, 5-year EFS rate, and LR rate were 49%, 37%, and 37%, respectively. The significant prognostic factors for survival were NF-1 status, tumor size, depth, location, malignant grade, margin status, chemotherapy, and radiotherapy. Age and sex were not associated with survival.Conclusion: Survival and local recurrence of MPNST are poor. Worse prognosis is mainly associated with NF 1 mutation, large size, deep to fascia, high grade, metastases and location (trunk and head & neck). Complete resection with adequate surgical margins is the mainstay protective factor of MPNST patients, following necessary adjuvant therapies.

scholarly journals Prevalence and risk factors of depression in Chinese patients with type 2 diabetes mellitus: a protocol of systematic review and meta-analysis

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Xiaobo Liu ◽  
Chao Dong ◽  
Hong Jiang ◽  
Dongling Zhong ◽  
Yuxi Li ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Systematic Review ◽  
Potential Risk ◽  
Meta Analysis ◽  
Risk Of Bias ◽  
Chinese Patients ◽  
Prevalence Of Depression ◽  
Potential Risk Factors

Abstract Background The prevalence of type 2 diabetes mellitus (T2DM) is growing in China. Depression is a significant complication of T2DM, leading to poor management of T2DM. Thus, early detection and treatment of depression in patients with T2DM are essential and effective. Therefore, we plan to conduct a systematic review and meta-analysis to evaluate the prevalence of depression in Chinese patients with T2DM and explore potential risk factors of depression in T2DM. Methods We will search literatures recorded in MEDLINE, EMBASE, the Cochrane Library, Chinese Biomedical Literature Database (CBM), China National Knowledge Infrastructure (CNKI), Chinese Science and Technology Periodical Database (VIP), and WanFang Database from their inception onwards. We will manually search gray literatures, reference lists of identified studies, relevant websites, and consult experts in this field. We will include population-based, cross-sectional surveys that investigated the prevalence of depression in Chinese patients with T2DM or/and the possible risk factors of depression in T2DM. Two reviewers will screen studies, extract data, and evaluate risk of bias independently. Agency for Healthcare Research and Quality methodology checklist will be used to assess the risk of bias. If feasible, we will conduct random effects meta-analysis of observational data to summarize the pooled prevalence, and use odds ratio for categorical data to explore potential risk factors. Prevalence estimates will be stratified according to age, gender, and other factors. Statistical heterogeneity will be estimated using Cochran’s Q and I2 index. We will conduct meta-regression to investigate the potential sources of heterogeneity, sensitivity analyses to assess robustness of the synthesized results, and funnel plots and Egger’s test to assess publication bias. Discussion This systematic review and meta-analysis will provide comprehensive evidence of the prevalence and potential risk factors of depression in Chinese patients with T2DM. We expect to provide evidence for healthcare practitioners and policy makers to pay attention to the mental health of patients with T2DM. Our data will highlight the need and importance of early detection and intervention for depression in patients with T2DM. Systematic review registration PROSPERO CRD42020182979.

scholarly journals Prognosis and risk factors for malignant peripheral nerve sheath tumor: a systematic review and meta-analysis

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Zhenyu Cai ◽  
Xiaodong Tang ◽  
Haijie Liang ◽  
Rongli Yang ◽  
Taiqiang Yan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Potential Risk ◽  
Protective Factor ◽  
Meta Analysis ◽  
Nerve Sheath Tumor ◽  
Pooled Data ◽  
Large Size ◽  
Potential Risk Factors ◽  
Malignant Grade

Abstract Background No available meta-analysis was printed to systematically introduce the MPNST clinic outcome and risk factors based on largely pooled data. This systematic review and meta-analysis aimed to investigate 5-year OS rate, 5-year EFS rate, and LR rate for MPNST, and to assess potential risk factors for prognosis. Methods Electronic articles published between January 1, 1966 and February 29, 2020 were searched and critically evaluated. The authors independently reviewed the abstracts and extracted data for 5-year OS rate, 5-year EFS rate, LR rate, and potential risk factors for prognosis. Results Twenty-eight literatures were finally included for meta-analysis. The pooled 5-year OS rate, 5-year EFS rate, and LR rate were 49%, 37%, and 38%, respectively. The significant prognostic factors for survival were NF1 status, tumor size, depth, location, malignant grade, margin status, chemotherapy, and radiotherapy. Age and sex were not associated with survival. Conclusion Survival and local recurrence of MPNST are poor. Worse prognosis is mainly associated with NF 1, large size, deep to fascia, high grade, metastases, and location (trunk and head and neck). Complete resection with adequate surgical margins is the mainstay protective factor of MPNST patients, following necessary adjuvant therapies.

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