prosthetic joint
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2022 ◽  
Vol 13 ◽  
pp. 7
Author(s):  
Richard M. Danilkowicz ◽  
Anne M. Lachiewicz ◽  
Daniel J. Lorenzana ◽  
Karen D. Barton ◽  
Paul F. Lachiewicz

eLife ◽  
2022 ◽  
Vol 11 ◽  
Author(s):  
Lisanne de Vor ◽  
Bruce van Dijk ◽  
Kok van Kessel ◽  
Jeffrey S Kavanaugh ◽  
Carla de Haas ◽  
...  

Implant-associated Staphylococcus aureus infections are difficult to treat because of biofilm formation. Bacteria in a biofilm are often insensitive to antibiotics and host immunity. Monoclonal antibodies (mAbs) could provide an alternative approach to improve the diagnosis and potential treatment of biofilm-related infections. Here, we show that mAbs targeting common surface components of S. aureus can recognize clinically relevant biofilm types. The mAbs were also shown to bind a collection of clinical isolates derived from different biofilm-associated infections (endocarditis, prosthetic joint, catheter). We identify two groups of antibodies: one group that uniquely binds S. aureus in biofilm state and one that recognizes S. aureus in both biofilm and planktonic state. Furthermore, we show that a mAb recognizing wall teichoic acid (clone 4497) specifically localizes to a subcutaneously implanted pre-colonized catheter in mice. In conclusion, we demonstrate the capacity of several human mAbs to detect S. aureus biofilms in vitro and in vivo.


Cureus ◽  
2022 ◽  
Author(s):  
Panagiotis V Samelis ◽  
Eftychios Papagrigorakis ◽  
Eleni Sameli ◽  
Andreas Mavrogenis ◽  
Olga Savvidou ◽  
...  

2022 ◽  
Author(s):  
Álvaro Auñón ◽  
Ismael Coifman ◽  
Antonio Blanco ◽  
Joaquín García Cañete ◽  
Raúl Parrón‐Cambero ◽  
...  

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