scholarly journals Single nucleotide polymorphisms in the gene encoding the major histocompatibility complex class II transactivator (CIITA) in systemic lupus erythematosus

2005 ◽  
Vol 64 (6) ◽  
pp. 947-950 ◽  
Author(s):  
K Koizumi
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Major Histocompatibility Complex ◽  
Lupus Erythematosus ◽  
Nucleotide Polymorphisms ◽  
Complex Class ◽  
Systemic Lupus ◽  
Gene Encoding ◽  
Class Ii Transactivator ◽  
Single Nucleotide ◽  
Histocompatibility Complex

Major histocompatibility complex genes and susceptibility to systemic lupus erythematosus

1990 ◽  
Vol 33 (10) ◽  
pp. 1542-1553 ◽  
Author(s):  
Zdenka Fronek ◽  
Luika A. Timmerman ◽  
Chester A. Alper ◽  
Bevra H. Hahn ◽  
Kenneth Kalunian ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Major Histocompatibility Complex ◽  
Lupus Erythematosus ◽  
Major Histocompatibility ◽  
Systemic Lupus ◽  
Histocompatibility Complex

A case of generalized pustular psoriasis caused by hydroxychloroquine in a patient with systemic lupus erythematosus

Lupus ◽  
2019 ◽  
Vol 28 (8) ◽  
pp. 1017-1020 ◽  
Author(s):  
E Shindo ◽  
K Shikano ◽  
M Kawazoe ◽  
T Yamamoto ◽  
N Kusunoki ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Neutrophil Infiltration ◽  
Pustular Psoriasis ◽  
Nucleotide Polymorphisms ◽  
Systemic Lupus ◽  
Single Nucleotide ◽  
Potential Development ◽  
Generalized Pustular Psoriasis ◽  
The Face

Hydroxychloroquine (HCQ) has been used to treat systemic lupus erythematosus (SLE) in Japan since 2015. We herein report a case of SLE that developed generalized pustular psoriasis (GPP) following the administration of HCQ. Twenty-one days after the HCQ treatment, a pustular rash with itching appeared on the auricle, scalp, and forearm, and spread rapidly to the face and body trunk with a high fever and arthralgia. Skin biopsy showed pustule formation under the cornified layer, neutrophil infiltration, the destruction of keratinocytes, and spongiform pustules of Kogoj. The patient was diagnosed with GPP. HCQ was immediately discontinued, the dose of prednisolone (PSL) was increased, and granulocyte and monocyte adsorption apheresis was performed. Her symptoms subsequently disappeared. Since arthralgia relapsed after the tapering of PSL, cyclosporine was added. Although single nucleotide polymorphisms (c.28C>T and c.115+6T>C) in the interleukin (IL)-36RN gene, which encodes the IL-36 receptor antagonist, have frequently been reported in GPP, these mutations were not observed in the present case. The potential development of GPP needs to be considered when administering HCQ to patients with SLE.

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