Etanercept during pregnancy and lactation in a patient with rheumatoid arthritis: drug levels in maternal serum, cord blood, breast milk and the infant's serum

2009 ◽  
Vol 68 (11) ◽  
pp. 1793-1794 ◽  
Author(s):  
A Murashima ◽  
N Watanabe ◽  
N Ozawa ◽  
H Saito ◽  
K Yamaguchi
Rheumatology ◽  
2019 ◽  
Vol 58 (8) ◽  
pp. 1505-1507 ◽  
Author(s):  
Jumpei Saito ◽  
Naho Yakuwa ◽  
Kayoko Kaneko ◽  
Chinatsu Takai ◽  
Mikako Goto ◽  
...  

2020 ◽  
pp. 1753495X2096609
Author(s):  
Jumpei Saito ◽  
Naho Yakuwa ◽  
Kayoko Kaneko ◽  
Mikako Goto ◽  
Hiroyo Kawasaki ◽  
...  

The demand for tocilizumab is increasing in women who wish to bear children and who have active rheumatoid arthritis. Described here is a woman with rheumatoid arthritis who discontinued her tocilizumab therapy at the end of the first trimester and resumed it after delivery and where tocilizumab levels in maternal serum, infant serum, and the breast milk were measured. Tocilizumab was not detected in maternal serum just before delivery, or in umbilical cord blood or infant serum after birth. Tocilizumab levels in colostrum after intravenous injection were 0.57% of those in serum. Tocilizumab treatment in the first trimester was not associated with a significant drug level in the fetus at delivery and no fetal complications were noted .


Author(s):  
Jumpei Saito ◽  
Asako Mito ◽  
Naho Yakuwa ◽  
Kayoko Kaneko ◽  
Hiroyo Kawasaki ◽  
...  

2018 ◽  
Vol 13 (2) ◽  
pp. 267-269 ◽  
Author(s):  
Entcho Klenske ◽  
Lourdes Osaba ◽  
Daniel Nagore ◽  
Timo Rath ◽  
Markus F Neurath ◽  
...  

2021 ◽  
Author(s):  
Jumpei Saito ◽  
Mariko Ishii ◽  
Yoriko Miura ◽  
Naho Yakuwa ◽  
Hiroyo Kawasaki ◽  
...  

2020 ◽  
Vol 15 (12) ◽  
pp. 809-812
Author(s):  
Jumpei Saito ◽  
Naho Yakuwa ◽  
Aiko Sasaki ◽  
Hiroyo Kawasaki ◽  
Tomo Suzuki ◽  
...  

2020 ◽  
Vol 15 (9) ◽  
pp. 598-601
Author(s):  
Jumpei Saito ◽  
Naho Yakuwa ◽  
Noriko Sandaiji ◽  
Hiroyo Kawasaki ◽  
Kayoko Kaneko ◽  
...  

Author(s):  
Jumpei Saito ◽  
Mariko Ishii ◽  
Asako Mito ◽  
Naho Yakuwa ◽  
Hiroyo Kawasaki ◽  
...  

2021 ◽  
Author(s):  
Jumpei Saito ◽  
Mariko Ishii ◽  
Asako Mito ◽  
Naho Yakuwa ◽  
Hiroyo Kawasaki ◽  
...  

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