Submucosal lesion of the oesophagus: not everything is what it seems

ABSTRACT Amphicrine carcinoma (AmC) is a unique epithelial tumor displaying exocrine and endocrine features in the same cell. It shows an adenocarcinoma-like cellular form and has endocrine granules. There are few reports describing chemotherapy for AmC. Here, we describe a case with metastatic AmC from the rectum that was treated with FOLFOXIRI chemotherapy. A 64-year-old man was diagnosed with a submucosal lesion on the scar produced after an endoscopic mucosal resection, which had been performed for adenocarcinoma of the rectum 2 years before. The endoscopic submucosal dissection revealed AmC. The abdominoperineal resection including lymph nodes dissection was performed. Thereafter, computed tomography showed multiple liver metastases, and FOLFOXIRI was administered. The best overall response was partial response, and progression-free survival was 8.7 months. After 16.0 months since first-line chemotherapy the patient died. We can therefore conclude that FOLFOXIRI may be effective for AmC of the rectum.

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Should We Collect a Biopsy From This Submucosal Lesion in the Cecum?

Gastroenterology ◽

10.1053/j.gastro.2018.04.041 ◽

2019 ◽

Vol 156 (1) ◽

pp. 34-35

Author(s):

Paul Vincent Co ◽

Richard Benya ◽

Mukund Venu

Keyword(s):

Submucosal Lesion

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Cap-Assisted Endoscopic Mucosal Resection of an Incidental Rectal Traumatic Neuroma

Case Reports in Gastrointestinal Medicine ◽

10.1155/2019/8328456 ◽

2019 ◽

Vol 2019 ◽

pp. 1-3

Author(s):

Elias Estifan ◽

Varun Patel ◽

Matthew Grossman

Keyword(s):

Endoscopic Mucosal Resection ◽

English Language ◽

Muscularis Propria ◽

Distal Stump ◽

Previous Surgery ◽

Acute Trauma ◽

Traumatic Neuroma ◽

Mucosal Resection ◽

Submucosal Lesion ◽

Language Literature

A traumatic neuroma is a well-known complication after acute trauma to a peripheral nerve; the nerve tries to re-establish continuity by an orderly growth of axons from the peripheral to distal stump through the proliferation of Schwann cells. However, this process is not always perfect, and aberrant repair gives rise to a neuroma. We present a 50-year-old female who underwent an initial colonoscopy for change in bowel habits and was found to have a 7 mm submucosal lesion in the proximal rectum. Endoscopic ultrasound was done which showed a hypoechoic lesion in the submucosal plane without muscularis propria invasion. The patient underwent successful cap-assisted endoscopic mucosal resection of the lesion without complication. Pathology of the specimen revealed a traumatic rectal neuroma with immunostaining positive for S100. However, this patient did not have any known risk factors such as previous surgery including polypectomy or hemorrhoidectomy or any previous rectal manipulation. Interestingly, this is the second case of traumatic rectal neuroma reported in the English-language literature.

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