scholarly journals Metastatic basaloid squamous cell carcinoma of thymic origin

2019 ◽  
Vol 12 (9) ◽  
pp. e228860
Author(s):  
Samuel Phen ◽  
Mindy X Wang ◽  
Matthew Kelling ◽  
Gurjaspreet K Bhattal

A 57-year-old man with a known anterior mediastinal mass presented with abdominal distension, jaundice, and signs of urinary and bowel obstruction. Labs revealed leukocytosis, transaminitis, direct hyperbilirubinaemia and elevated levels of alkaline phosphatase, lactate dehydrogenase and uric acid. Subsequent imaging revealed the anterior mediastinal mass and diffuse liver lesions consistent with metastatic disease. MRI of the spine and brain were negative for metastases. Liver biopsy and immunohistochemistry revealed basaloid squamous cell carcinoma of thymic origin. Treatment with capecitabine was initiated but was complicated by worsening liver and kidney failure. Eventually, due to continued worsening of the patient’s condition and minimal treatment response, capecitabine was stopped during cycle 1 and the patient was discharged to inpatient hospice with comfort care. In this case report, we highlight the presenting features, imaging findings and management of a patient with metastatic thymic carcinoma.

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Kumiko Sekiguchi ◽  
Takeshi Matsutani ◽  
Tsutomu Nomura ◽  
Nobutoshi Hagiwara ◽  
Akihisa Matsuda ◽  
...  

2021 ◽  
Vol 80 ◽  
pp. 105621
Author(s):  
Fumitaka Endo ◽  
Yuji Akiyama ◽  
Masazumi Onishi ◽  
Noriyuki Uesugi ◽  
Tamotsu Sugai ◽  
...  

BMC Cancer ◽  
2006 ◽  
Vol 6 (1) ◽  
Author(s):  
Grazia Salerno ◽  
Dolores Di Vizio ◽  
Stefania Staibano ◽  
Giampiero Mottola ◽  
Giuseppe Quaremba ◽  
...  

2021 ◽  
pp. 106689692199713
Author(s):  
Jijgee Munkhdelger ◽  
Tomoko Shimooka ◽  
Yoshinori Koyama ◽  
Sadakatsu Ikeda ◽  
Yoshiki Mikami ◽  
...  

There is a lack of knowledge about molecular alterations in basaloid squamous cell carcinoma (BSCC) of the uterine cervix. A 72-year-old woman with a history of previous subtotal hysterectomy and current vaginal bleeding was referred to our hospital. Initially, adenoid cystic carcinoma (ACC) was diagnosed upon cervical cytology and biopsy. Chest imaging showed multiple metastatic lesions in both lungs. The surgical specimen showed BSCC with diffuse p16 immunoreactivity and negativity for S-100, c-kit, and neuroendocrine markers. There was a focal minor ACC component, which could have explained the previous cytology and biopsy diagnosis. Next-generation sequencing with two different panels showed coexisting PIK3CA mutation and NTRK2 fusion with 10 additional variants of unknown significance ( ATR, DAXX, FAM123B, JAK1, KEL, MLL2, NOTCH2, PALB2, POLD1, POLE). The MYB gene fusions were not identified. The patient received chemotherapy with TRK inhibitor larotrectinib and carboplatin, which caused shrinkage of metastatic lung nodules. This is the first report of cervical BSCC with extensive molecular workup, which detected multiple genetic events, including targetable ones, which are potentially implicated in the development of a tumor. The accumulation of data and further studies on this tumor are necessary to define its diagnostic criteria and its clinical and biological behavior.


2009 ◽  
Vol 24 (3) ◽  
pp. 542 ◽  
Author(s):  
Yong Soon Kwon ◽  
Yong Man Kim ◽  
Ga Won Choi ◽  
Young Tak Kim ◽  
Joo-Hyun Nam

2012 ◽  
Vol 5 ◽  
pp. 447-450
Author(s):  
Deviprasad Shetty ◽  
Vijayalakshmi Subramaniam ◽  
Adarsha Herale ◽  
Prema Saldanha ◽  
Mahaveer Jain

Mutagenesis ◽  
2014 ◽  
Vol 30 (2) ◽  
pp. 297-301 ◽  
Author(s):  
T. Saito ◽  
H. Mitomi ◽  
A. Imamhasan ◽  
T. Hayashi ◽  
A. Kurisaki-Arakawa ◽  
...  

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