scholarly journals Atypical central neurocytoma with aggressive features in a child

2020 ◽  
Vol 13 (6) ◽  
pp. e236262 ◽  
Author(s):  
Scott Sun ◽  
Denise M Malicki ◽  
Michael L Levy ◽  
John Ross Crawford
2019 ◽  
Vol 122 ◽  
pp. 454-457 ◽  
Author(s):  
Vikas Singh ◽  
Ashwin Borkar ◽  
Aliasgar Moiyadi ◽  
Prakash Shetty

2016 ◽  
Vol 40 (6) ◽  
pp. 1108-1111 ◽  
Author(s):  
Megha Nayyar ◽  
Mary Catherine Mayo ◽  
Mark Shiroishi ◽  
Deborah Commins ◽  
Charles Y. Liu ◽  
...  

1997 ◽  
Vol 56 (5) ◽  
pp. 551-556 ◽  
Author(s):  
FIGEN SÖYLEMEZOGLU ◽  
BERND W. SCHEITHAUER ◽  
JACQUES ESTEVE ◽  
PAUL KLEIHUES

Author(s):  
Shikha Goyal ◽  
Tejinder Kataria ◽  
Deepak Gupta ◽  
Aruj Dhyani ◽  
Ishani Mohapatra ◽  
...  

Author(s):  
Jennyfer Paulla Galdino Chaves ◽  
Carlos Alberto Mattozo ◽  
Bruno Augusto Telles ◽  
Ana Paula Percicote ◽  
Zeferino Jr Demartini ◽  
...  

2014 ◽  
Vol 138 (9) ◽  
pp. 1233-1237 ◽  
Author(s):  
Lakshmi Vemavarapu ◽  
Irene Czyszczon ◽  
Joseph C. Parker ◽  
Stephanie Wagner ◽  
Todd Vitaz ◽  
...  

We report a case of an intraventricular tumor with features of atypical central neurocytoma with a sarcomatous component in a 44-year-old woman who presented with headaches and vomiting. Magnetic resonance imaging revealed a 3.4-cm lobulated enhancing mass in the occipital horn of the left lateral ventricle, and the patient subsequently underwent a left occipital-parietal craniotomy for debulking. The tumor contained 2 cell populations: round cells with perinuclear halos in a fibrillary background, and spindle cells with oval nuclei arranged in interlacing fascicles with focal necrosis. The round cells had diffuse synaptophysin immunopositivity, while the spindle cells were diffusely immunopositive for vimentin and had intercellular reticulin. The mitotic activity (8 mitotic figures per 10 high-power fields) and the high Ki-67 proliferation index (15.0%) were consistent with atypical central neurocytoma with a sarcomatous component. Although different histologic variants have been described, this is the first reported case, to our knowledge, of central neurocytoma with spindle cell sarcomatous features.


2009 ◽  
Vol 97 (3) ◽  
pp. 429-437 ◽  
Author(s):  
David Buchbinder ◽  
Moise Danielpour ◽  
William H. Yong ◽  
Noriko Salamon ◽  
Joseph Lasky

2019 ◽  
Vol 12 (1) ◽  
pp. bcr-2018-226455
Author(s):  
Yasmin Aghajan ◽  
Denise M Malicki ◽  
Michael L Levy ◽  
John Ross Crawford

We present the case of a 13-year-old boy with a very unusual periventricular atypical central neurocytoma with unique molecular features treated with subtotal surgical resection and photon intensity-modulated radiotherapy. Histological features were most consistent with atypical central neurocytoma. However, next-generation sequencing analysis revealed a novel EWSR1-ATF1 gene fusion (EWSR1-ATF1) as well as a MUTYH mutation. The EWSR1-ATF1 raised the possibility of Ewing sarcoma or angiomatoid fibrous histiocytoma, however, FLI-1 immunohistochemistry was negative. MUTYH mutations have been reported in diffuse midline paediatric glioma. The role of EWSR1-ATF1 and MUTYH mutations in central nervous system tumours is not well established. We present the first case of EWSR1-ATF1 and MUTYH mutation in a rare paediatric atypical central neurocytoma. Further studies are indicated to elucidate the consequences of these gene alterations in the context of paediatric central nervous system tumours as well as to investigate the potential role for targeted therapies.


1999 ◽  
Vol 91 (3) ◽  
pp. 506-509 ◽  
Author(s):  
Monika Warmuth-Metz ◽  
Rüdiger Klein ◽  
Niels Sörensen ◽  
Laszlo Solymosi

✓ The authors report on a 17-year-old boy who suffered from slowly progressive and long-standing symptoms of ataxia, neck pain, and headache. Computerized tomography (CT) and magnetic resonance (MR) imaging revealed a tumor arising from the floor of the fourth ventricle that resulted in a moderate hydrocephalus. A partial resection was performed. Histological and immunohistological findings led to the diagnosis of an atypical central neurocytoma of the fourth ventricle. The imaging features on CT scanning, MR imaging, and proton MR spectroscopy studies, the clinical picture, and the prognosis of this very unusual tumor are discussed. Three cases of neurocytomas in the posterior fossa have been described to date; however, in all three cases some atypical aspects were present. In the present case, with the exception of the very unusual location, both imaging findings and clinical history perfectly met the definition of this rare tumor.


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