Mixed infection of Actinomyces israelii and Fusobacterium nucleatum presenting as a neck mass

This report presents the case of a mixed infection of Actinomyces israelii and Fusobacterium nucleatum, presenting as an extensive neck mass progressing through tissue planes and causing bony destruction. Despite multiple abscess aspirates, imaging and serological investigations, the causative organisms proved elusive over the course of the patient’s long admission, only to be identified postdischarge. The patient was successfully initiated on a prolonged course of intravenous antibiotics and did not suffer from any complications. This report aims to raise awareness of the presentation, pathogenicity and treatment of Actinomyces and Fusobacteria infections, given a notable difficulty in diagnosis.

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The virulence of mixed infection with Streptococcus constellatus and Fusobacterium nucleatum in a murine orofacial infection model

Microbes and Infection ◽

10.1016/s1286-4579(00)01296-x ◽

2000 ◽

Vol 2 (12) ◽

pp. 1425-1430 ◽

Cited By ~ 25

Author(s):

Tomoari Kuriyama ◽

Kiyomasa Nakagawa ◽

Shuichi Kawashiri ◽

Etsuhide Yamamoto ◽

Shinichi Nakamura ◽

...

Keyword(s):

Mixed Infection ◽

Fusobacterium Nucleatum ◽

Infection Model ◽

Streptococcus Constellatus

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Mixed infection with Porphyromonas gingivalis and Fusobacterium nucleatum in a murine lesion model: potential synergistic effects on virulence.

Infection and Immunity ◽

10.1128/iai.64.6.2094-2100.1996 ◽

1996 ◽

Vol 64 (6) ◽

pp. 2094-2100 ◽

Cited By ~ 72

Author(s):

F Feuille ◽

J L Ebersole ◽

L Kesavalu ◽

M J Stepfen ◽

S C Holt

Keyword(s):

Porphyromonas Gingivalis ◽

Mixed Infection ◽

Synergistic Effects ◽

Fusobacterium Nucleatum ◽

Model Potential

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Methicillin-Sensitive Staphylococcus aureus Suppurative Thyroiditis with Thyrotoxicosis

Case Reports in Emergency Medicine ◽

10.1155/2017/4018193 ◽

2017 ◽

Vol 2017 ◽

pp. 1-3

Author(s):

Sha Yan ◽

Laryssa Patti

Keyword(s):

Staphylococcus Aureus ◽

Fine Needle Aspiration ◽

Needle Aspiration ◽

Neck Mass ◽

Good Resolution ◽

Suppurative Thyroiditis ◽

Fine Needle ◽

Intravenous Antibiotics ◽

History Of ◽

Acute Suppurative Thyroiditis

Intravenous drug use (IVDU) can lead to numerous complications from skin abscesses to bacteremia to endocarditis. Here, we present a rare case of acute suppurative thyroiditis as a complication of IVDU, in which a 26-year-old female with a past medical history of IVDU presented to the emergency department for evaluation of a large right sided neck mass. On exam, she had signs of sepsis and thyrotoxicosis. Fine needle aspiration confirmed suppurative thyroiditis. Blood cultures and culture from fine needle aspiration grew Staphylococcus aureus. Patient was treated with 2 weeks of intravenous antibiotics with good resolution of her symptoms.

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Paediatric neck abscesses: microbiology and management

The Journal of Laryngology & Otology ◽

10.1017/s0022215107009085 ◽

2007 ◽

Vol 122 (5) ◽

pp. 480-484 ◽

Cited By ~ 5

Author(s):

I K Rustom ◽

J A T Sandoe ◽

Z G G Makura

Keyword(s):

Mycobacterial Infection ◽

Neck Mass ◽

Atypical Mycobacteria ◽

Incision And Drainage ◽

Presenting Symptoms ◽

General Infirmary ◽

Intravenous Antibiotics ◽

Atypical Mycobacterial Infection ◽

The Mean

AbstractIntroduction:Paediatric neck abscesses remain common problems which are sometimes difficult to manage.Methods and materials:We conducted a retrospective study of 64 children who underwent incision and drainage of neck abscesses at Leeds General Infirmary from 1 February 2002 to 31 July 2006. The aim of this study was to identify the presenting symptoms in children, the appropriateness of prescribed antibiotics and the role of atypical mycobacteria in neck infections. The outcome measure was clinical resolution of the abscess.Results:The mean presenting age was 44.2 months (3.68 years). The commonest sign and symptom was neck mass (96.9 per cent). The mean period of hospitalisation was 3.7 (± standard deviation of 1.9) days. Staphylococcus aureus (48.4 per cent) was the commonest organism cultured. Atypical mycobacteria were found in only 4.7 per cent of the specimens. Flucloxacillin was the most common antibiotic used (57.8 per cent), often in combination with other antimicrobials. The abscess recurrence rate was 4.7 per cent. No fatalities occurred in this series of patients.Conclusion:Appropriately prescribed intravenous antibiotics and surgical drainage remain the central core of treatment. Atypical mycobacterial infection is an important differential diagnosis of a painless, cervico-facial mass. An algorithm for the management of paediatric neck abscesses is proposed.

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Endoscopic electrocautery and fibrin obliteration of an acutely complicated pyriform fossa sinus tract in a septuagenarian

The Journal of Laryngology & Otology ◽

10.1017/s0022215117001177 ◽

2017 ◽

Vol 131 (10) ◽

pp. 933-936

Author(s):

R Heyes ◽

A G Aulakh ◽

R K Lingam ◽

T Tatla

Keyword(s):

Case Report ◽

Fibrin Glue ◽

Fluid Collection ◽

Complete Recovery ◽

Sinus Tract ◽

Neck Mass ◽

Suppurative Thyroiditis ◽

Incision And Drainage ◽

Pyriform Fossa ◽

Intravenous Antibiotics

AbstractBackground:Pyriform fossa sinus tracts classically present with neck abscess, recurrent infections and suppurative thyroiditis in children; acute presentation in a geriatric patient is rare.Methods:Case report and Medline literature review.Case report:A 79-year-old female presented with a left-sided neck mass and severe odynophagia of 3 days’ duration. Magnetic resonance imaging revealed a large-volume, loculated fluid collection extending throughout the deep spaces of the neck on the left, within and around the thyroid gland capsule. There was radiological evidence of internal jugular vein thrombophlebitis. Abscess incision and drainage, and endoscopic evaluation, were performed. A deeply penetrating sinus was seen in the left pyriform apex, the entrance of which was circumferentially cauterised and the lumen obliterated with fibrin glue. Following post-operative intravenous antibiotics, the patient made a complete recovery.Conclusion:This paper describes the first use of fibrin glue to obliterate a pyriform fossa sinus tract in an adult.

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Fusobacterium nucleatum and Tannerella forsythia Induce Synergistic Alveolar Bone Loss in a Mouse Periodontitis Model

Infection and Immunity ◽

10.1128/iai.06276-11 ◽

2012 ◽

Vol 80 (7) ◽

pp. 2436-2443 ◽

Cited By ~ 41

Author(s):

Rajendra P. Settem ◽

Ahmed Taher El-Hassan ◽

Kiyonobu Honma ◽

Graham P. Stafford ◽

Ashu Sharma

Keyword(s):

Bone Loss ◽

Mixed Infection ◽

Alveolar Bone ◽

Fusobacterium Nucleatum ◽

Single Species ◽

Opportunistic Pathogen ◽

Alveolar Bone Loss ◽

Tannerella Forsythia ◽

Content Type ◽

Jaw Bones

ABSTRACTTannerella forsythiais strongly associated with chronic periodontitis, an inflammatory disease of the tooth-supporting tissues, leading to tooth loss.Fusobacterium nucleatum, an opportunistic pathogen, is thought to promote dental plaque formation by serving as a bridge bacterium between early- and late-colonizing species of the oral cavity. Previous studies have shown thatF. nucleatumspecies synergize withT. forsythiaduring biofilm formation and pathogenesis. In the present study, we showed that coinfection ofF. nucleatumandT. forsythiais more potent than infection with either species alone in inducing NF-κB activity and proinflammatory cytokine secretion in monocytic cells and primary murine macrophages. Moreover, in a murine model of periodontitis, mixed infection with the two species induces synergistic alveolar bone loss, characterized by bone loss which is greater than the additive alveolar bone losses induced by each species alone. Further, in comparison to the single-species infection, mixed infection caused significantly increased inflammatory cell infiltration in the gingivae and osteoclastic activity in the jaw bones. These data show thatF. nucleatumsubspecies andT. forsythiasynergistically stimulate the host immune response and induce alveolar bone loss in a murine experimental periodontitis model.

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The role of coaggregation between Porphyromonas gingivalis and Fusobacterium nucleatum on the host response to mixed infection

Journal Of Clinical Periodontology ◽

10.1111/j.1600-051x.2012.01889.x ◽

2012 ◽

Vol 39 (7) ◽

pp. 617-625 ◽

Cited By ~ 15

Author(s):

David Polak ◽

Lior Shapira ◽

Ervin I. Weiss ◽

Yael Houri-Haddad

Keyword(s):

Porphyromonas Gingivalis ◽

Mixed Infection ◽

Host Response ◽

Fusobacterium Nucleatum

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An unusual case of abdominal pain and splenomegaly in a paediatric patient

SAGE Open Medical Case Reports ◽

10.1177/2050313x21991059 ◽

2021 ◽

Vol 9 ◽

pp. 2050313X2199105

Author(s):

Eric J Eckbo ◽

Hana Mijovic ◽

Jennifer Tam ◽

David M Goldfarb ◽

Tobias R Kollmann

Keyword(s):

Paediatric Patient ◽

Opportunistic Infections ◽

Wide Spectrum ◽

Anaerobic Bacteria ◽

Splenic Abscess ◽

Fusobacterium Nucleatum ◽

Oral Microbiota ◽

Metagenomic Sequencing ◽

Intravenous Antibiotics ◽

Intra Abdominal Infection

Fusobacterium species are members of the oral microbiota and have been found to cause a wide spectrum of opportunistic infections. We describe the case of a previously healthy teenager with a large splenic abscess secondary to Fusobacterium nucleatum, successfully managed with percutaneous drainage and intravenous antibiotics. Identification of the organism was achieved using anaerobic culture of the aspirated fluid and matrix-assisted laser desorption/ionization time of flight, later confirmed by 16S ribosomal RNA metagenomic sequencing of the fluid. Fusobacteria are typically associated with oropharyngeal infections but are very rarely implicated in splenic abscesses. Aerobic and anaerobic blood cultures should be drawn when an intra-abdominal infection is suspected in a paediatric patient, and empiric antimicrobial therapy should be administered with coverage for gram-positive, gram-negative, and anaerobic bacteria.

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