A rare case of atypical bone marrow sarcoidosis without pulmonary involvement in a Japanese woman

2021 ◽  
Vol 14 (6) ◽  
pp. e240577
Author(s):  
Maki Iwata ◽  
Tatsuya Kodama ◽  
Hiroaki Takeo ◽  
Norikazu Mataki
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Involvement ◽  
Unknown Origin ◽  
Pulmonary Involvement ◽  
Japanese Woman ◽  
Emission Tomography ◽  
Systemic Glucocorticoid ◽  
Positron Emission ◽  
Granulomatous Lesions ◽  
Hepatic Sarcoidosis

Sarcoidosis is a systemic granulomatous disease of unknown origin characterised by the presence of non-caseating granulomatous lesions. Extrapulmonary sarcoidosis with bone marrow involvement is rare and even more so without pulmonary involvement. Here, we describe a case of 69-year-old woman diagnosed as having bone marrow and hepatic sarcoidosis without pulmonary involvement based on 18F-fluorodeoxyglucose positron emission tomography findings. She was successfully treated with systemic glucocorticoid therapy.

18-F-fluorodeoxyglucose-positron emission tomography as a new approach to detect lymphomatous bone marrow.

1998 ◽  
Vol 16 (2) ◽  
pp. 603-609 ◽  
Author(s):  
F Moog ◽  
M Bangerter ◽  
J Kotzerke ◽  
A Guhlmann ◽  
N Frickhofen ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Bone Marrow ◽  
Malignant Lymphoma ◽  
Fdg Pet ◽  
Bone Marrow Involvement ◽  
False Negative ◽  
High Rate ◽  
Emission Tomography ◽  
Positron Emission ◽  
Negative Findings

PURPOSE Bone marrow involvement in patients with malignant lymphoma is considered a sign of generalized disease with less favorable prognosis. Bone marrow biopsy (BMB), which represents the standard diagnostic procedure, however, is associated with a high rate of false-negative findings, which may lead to errors in management. The present study was undertaken to investigate the efficacy of positron emission tomography (PET) with 18-F-fluorodeoxyglucose (FDG-PET) as a new method to evaluate bone marrow involvement in patients with malignant lymphoma. METHODS Seventy-eight consecutive, untreated patients with either non-Hodgkin's lymphoma (NHL; n = 39) or Hodgkin's disease (HD; n = 39) were prospectively evaluated. Static FDG-PET imaging was performed following application of 270 MBq (F-18)-FDG. Attenuation correction was performed in 63 of 78 patients. Visual evaluation was performed by two examiners unaware of the clinical data. Material for BMB (70 bilateral, 8 unilateral) was obtained from the posterior iliac crest. Discordant results of PET and biopsy were settled, when possible, on the basis of further biopsy or magnetic resonance imaging (MRI). RESULTS In addition to seven concordant positive and 57 concordant negative findings, biopsy revealed another four cases with bone marrow involvement not detectable by FDG-PET analysis (+5.1%). On the contrary, PET showed bone marrow areas of intensive FDG uptake that suggested bone marrow lymphoma in 10 patients with negative biopsies (+12.8%). In eight patients, FDG-PET findings were confirmed by either histologic verification (n = 4), MRI (n = 2), polymerase chain reaction (PCR) for rearranged immunoglobulin H sequences (n = 1), or clinical presentation (n = 1). Two cases remained unresolved. CONCLUSION The results indicate that FDG-PET has a high potential to detect bone marrow involvement in malignant lymphoma. Besides confirming lesions found at BMB, FDG-PET provided additional information, which, in eight of 78 patients (10.3%), led to an upgrade of the tumor stage.

scholarly journals Fluorine-18 Fluorodeoxyglucose with Positron Emission Tomography Revealed Bone Marrow Involvement in Sarcoidosis Patients with Anaemia

Respiration ◽  
2010 ◽  
Vol 79 (1) ◽  
pp. 25-31 ◽  
Author(s):  
Nicolas de Prost ◽  
Khaldoun Kerrou ◽  
Mathilde Sibony ◽  
Jean-Noël Talbot ◽  
Marie Wislez ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Bone Marrow ◽  
Bone Marrow Involvement ◽  
Emission Tomography ◽  
Positron Emission ◽  
Fluorine 18 Fluorodeoxyglucose
Sign in / Sign up

Export Citation Format

Share Document