Castleman’s disease masquerading as pancreatic neuroendocrine tumour

2021 ◽  
Vol 14 (6) ◽  
pp. e242597
Author(s):  
Deepika Gunda ◽  
Jack Naughton ◽  
Sean Gregory Stevens ◽  
Marcos V Perini
Keyword(s):  
Histopathological Examination ◽  
Neuroendocrine Tumour ◽  
Incidental Finding ◽  
Castleman’S Disease ◽  
Disease Recurrence ◽  
Castleman's Disease ◽  
Positron Emission ◽  
Open Distal Pancreatectomy ◽  
Rheumatological Disease ◽  
Pancreatic Neuroendocrine Tumour

Castleman’s disease (CD) is a rare lymphoproliferative disorder. This case report, to the best of our knowledge, is the first report of CD simulating a pancreatic neuroendocrine tumour . The patient was a 58-year-old woman who initially presented with bilateral iritis and underwent investigation for possible systemic rheumatological disease. CT of the chest demonstrated an incidental finding of a well-demarcated retropancreatic mass. As the mass was found to enhance on DOTATATE (tetraazacyclododecanetetraacetic acid-DPhe1-Tyr3-octreotate) positron emission tomography, a diagnosis of pancreatic neuroendocrine tumour was made. The patient underwent an open distal pancreatectomy and splenectomy. Histopathological examination revealed the unexpected diagnosis of hyaline vascular CD of a lymph node posterior to the pancreas. After 2 years of follow-up, there is no evidence of disease recurrence.

scholarly journals Mesenteric Castleman’s disease mimicking neuroendocrine tumour

2019 ◽  
Vol 63 ◽  
pp. 56-58 ◽  
Author(s):  
Ricky H. Bhogal ◽  
Andrew Wotherspoon ◽  
Aamir K. Khan
Keyword(s):  
Neuroendocrine Tumour ◽  
Castleman’S Disease ◽  
Castleman's Disease

scholarly journals Retroperitoneal pararenal castleman’s disease: a case report

2013 ◽  
Vol 3 (6) ◽  
pp. 509-511
Author(s):  
S Shrestha ◽  
U Nepal ◽  
N Lamichhane ◽  
P Chhetri
Keyword(s):  
Preoperative Diagnosis ◽  
Histopathological Examination ◽  
Castleman’S Disease ◽  
Accurate Diagnosis ◽  
Renal Tumors ◽  
Unknown Etiology ◽  
Resected Specimen ◽  
Castleman's Disease ◽  
Vascular Type ◽  
Hyaline Vascular Type

Castleman’s diseas is a rare lymphoproliferative disorder of unknown etiology. We report a 28 years old woman with solitary Castleman’s disease in the left pararenal space. This case was diagnosed preoperatively as renal cell carcinoma. The patient underwent a radical nephrectomy with dissection of pararenal mass. Histopathological examination of the surgically resected specimen showed the hyaline vascular type of Castleman’s disease. A preoperative diagnosis of Castleman’s disease is difficult; therefore, a surgical resection and histopathological evaluation can provide an accurate diagnosis of tumor. Taking this case into consideration, we suggest that Castleman’s disease should be included in the differential diagnosis of renal tumors. DOI: http://dx.doi.org/10.3126/jpn.v3i6.9004 Journal of Pathology of Nepal (2013) Vol. 3, 509-511

scholarly journals Incidental finding of Castleman's disease in an asymptomatic young adult

2009 ◽  
Vol 2009 (dec09 1) ◽  
pp. bcr0620092039-bcr0620092039
Author(s):  
I. Shahbuddin ◽  
D. McKeon
Keyword(s):  
Young Adult ◽  
Incidental Finding ◽  
Castleman’S Disease ◽  
Castleman's Disease

scholarly journals Retroperitoneal Castleman’s Disease

2019 ◽  
Vol 12 (3) ◽  
pp. 885-889
Author(s):  
Kota Shimokihara ◽  
Takashi Kawahara ◽  
Ryo Kasahara ◽  
Jun Kasuga ◽  
Shinpei Sugiura ◽  
...  
Keyword(s):  
Lymphoproliferative Disorder ◽  
Rare Case ◽  
Castleman’S Disease ◽  
Retroperitoneal Tumor ◽  
Emission Tomography ◽  
Castleman's Disease ◽  
Vascular Type ◽  
Positron Emission ◽  
Hyaline Vascular Type ◽  
Aortic Area

Castleman’s disease was first reported in 1954 by Castleman et al. and identified as an uncommon lymphoproliferative disorder. In most cases, Castleman’s diseases are detected in the chest, head, and neck. A 71-year-old man was referred to our hospital due to a retroperitoneal tumor in the para-aortic area by computed tomography (CT). Positron emission tomography-CT revealed an uptake in this tumor, suggesting malignant diseases. Laparoscopic tumorectomy was performed, and the pathological diagnosis was Castleman’s disease, hyaline vascular type. No evidence of recurrence was observed 20 months after surgery. We herein report a rare case of retroperitoneal Castleman’s disease.

scholarly journals Localized Castleman’s Disease in the Breast in a Young Woman

2016 ◽  
Vol 2016 ◽  
pp. 1-3 ◽  
Author(s):  
Rafael Parra-Medina ◽  
José Ismael Guio ◽  
Patricia López-Correa
Keyword(s):  
Lymphoproliferative Disorder ◽  
Histopathological Examination ◽  
Castleman’S Disease ◽  
Unknown Etiology ◽  
Castleman's Disease ◽  
Axillary Lymphadenopathy ◽  
The Right ◽  
Slow Growing ◽  
Hyaline Vascular Variant

Castleman’s disease (CD) is a rare lymphoproliferative disorder of unknown etiology. It typically occurs in adulthood but it may also develop in childhood. Clinically, this disease may be classified as localized (unicentric) or systemic (multicentric). Six cases of breast CD have been described in the literature, and all have been reported in adults. Herein we describe the case of a 15-year-old female who presented with a slow-growing tumor in the right breast. The tumor was excised and histopathological examination demonstrated hyaline vascular variant CD. After two years of follow-up, the patient was asymptomatic without evidence of cervical or axillary lymphadenopathy.

scholarly journals Castleman's Disease - Unicentric Plasma Cell Variant - A Case Report with Review of Literature

JMS SKIMS ◽  
2012 ◽  
Vol 15 (1) ◽  
pp. 57-60
Author(s):  
Abdul Rashid Lone ◽  
Sheikh Aejaz Aziz ◽  
Syed Nisar Ahmad ◽  
Mir Mohammad Hussain ◽  
Ulfat Ara ◽  
...  
Keyword(s):  
Plasma Cell ◽  
Histopathological Examination ◽  
Castleman’S Disease ◽  
Lymph Node Excision ◽  
Excision Biopsy ◽  
Castleman's Disease ◽  
Rare Location ◽  
Cell Variant ◽  
General Signs ◽  
Localized Form

Castleman's disease (CD) is a rare disease with two identified forms. The localized form, often pauci symptomatic is characterized by enlargement of an isolated single lymphnode or lymphnode chain. Multicenteric form frequently presents with general signs. We report a patient who presented with cough and hemoptysis with imaging revealing right hilar lymphadenopathy. After thoracotomy, lymph node excision biopsy was done, histopathological examination revealed plasma cell - variant (PCV) of CD, a rare location for unicentric PCV of CD. JMS 2012;15(1):57-60.

scholarly journals Fibroblast Growth Factor-23 Secreting Tumour Induced Osteomalacia

2021 ◽  
Vol 8 (2) ◽  
Author(s):  
Economos H ◽  
◽  
Bonar F ◽  
Diamond T ◽  
◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Histopathological Examination ◽  
Incidental Finding ◽  
Fibroblast Growth Factor 23 ◽  
Tumour Resection ◽  
Fibroblast Growth ◽  
Positron Emission ◽  
Pathologic Fractures ◽  
Fgf 23

Tumour Induced Osteomalacia (TIO) caused by a Fibroblast-Growth- Factor-23 (FGF-23) secreting tumour is a rare paraneoplastic disorder. Patients often present with non-specific complaints of pain and stiffness however findings of hypophosphataemia and inappropriately suppressed 1,25 dihidroxyvitamin D are almost pathognemonic of this condition. We present a previously healthy 51-year-old man who presented with an 18 month history of body aches, hypophosphataemia, and an incidental finding of atraumatic foot fractures on x-ray. Technetium bone scan identified diffuse skeletal pathologic fractures. He was further found to have persistent hypophosphataemia, suppressed 1-25-dihidroxyvitamin-D, renal phosphate wasting with reduced Tubular Reabsorption of Phosphate (TRP), and an FGF-23 level more than twice the upper limit of normal. Fluorodeoxyglucose (FDG) Positron Emission Tomography (PET), Gallium-68 Dotatate PET and magnetic resonance imaging further identified and characterised a 40 mm FDG and Dotatate-avid lesion in the right third rib. Histopathological examination of a biopsy specimen revealed phosphaturic mesenchymal tumour with positive FGF-23 immunohistochemical staining arising in a background consistent with osteomalacia. After tumour resection, the patient’s hypophosphataemia, reduced TRP and elevated FGF- 23 normalised and he made an excellent recovery with rehabilitation. This case report illustrates the importance of a diagnosis of hypophosphataemia in a patient with musculo-skeletal aches and alerts clinicians of the differential diagnosis of TIO.

scholarly journals Different Imaging Features of Retroperitoneal Unicentric Castleman’s Disease: A Case Report

2020 ◽  
Vol 13 (1) ◽  
pp. 468-473
Author(s):  
Yonghong Cao ◽  
Erlan Shi ◽  
Jun Ye ◽  
Rong Zhang ◽  
Yunsheng Wang ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Malignant Disease ◽  
Laparoscopic Resection ◽  
Castleman’S Disease ◽  
The Body ◽  
Imaging Features ◽  
Castleman's Disease ◽  
Vascular Type ◽  
Positron Emission ◽  
Hyaline Vascular Type

Castleman’s disease is a rare disease which is difficult to diagnose early due to its lack of specific manifestations, and also is easily confused with lymphoma or other solid tumors. Castleman’s disease can occur in any part of the body containing lymph nodes and is most common in the chest, followed by the neck, abdomen, and axillae. A 37-year-old woman was admitted to our hospital because of a tumor near the adrenal gland found by computed tomography. Positron emission tomography-computed tomography revealed that the retroperitoneal tumor may be a malignant disease. However, the pathological diagnosis after laparoscopic resection was retroperitoneal Castleman’s disease, hyaline vascular type.

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