Case of labial sclerosing polycystic adenoma with ductal carcinoma in situ (DCIS)

2021 ◽  
Vol 14 (8) ◽  
pp. e243736
Author(s):  
Soumya Makarla ◽  
Radhika M Bavle ◽  
Reshma Venugopal ◽  
Sudhakara Muniswamappa
Keyword(s):  
Salivary Gland ◽  
Ductal Carcinoma ◽  
Minor Salivary Gland ◽  
Histopathological Diagnosis ◽  
Epithelial Proliferation ◽  
Upper Lip ◽  
Salivary Gland Tumours ◽  
Pleomorphic Adenomas ◽  
Rare Lesion

Minor salivary gland tumours are enigmatic in their behaviour and presentations. Histopathological diagnosis of these tumours encompasses a large spectrum. Conventionally, small nodular tumours of the upper lip or the labial mucosa are generally adenomas, frequently pleomorphic adenomas. Here, we describe a case of a solitary nodular tumour, occurring in the upper labial mucosa, diagnosed as sclerosing polycystic adenoma (SPA) with intraductal epithelial proliferation of high grade. This is a rare lesion, which has entered into the category of salivary gland tumours recently in the 2017 WHO categorisation. We report a case of paucicystic SPA with intraductal epithelial proliferations in the labial minor salivary gland of a 56-year-old woman, which might be the first report of a case occurring in the upper labial mucosa.

scholarly journals SALIVARY GLAND TUMOURS;

2017 ◽  
Vol 24 (09) ◽  
pp. 1327-1330
Author(s):  
Arifullah - ◽  
Irfan Ul Islam Nasir ◽  
Syed Zafar Hassan ◽  
Ghulam Muhammad
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Minor Salivary Gland ◽  
Salivary Gland Tumours ◽  
Surgical Department ◽  
Adenoid Cystic ◽  
Pleomorphic Adenomas ◽  
Warthin’S Tumour ◽  
Benign Tumours ◽  
Common Benign Tumour

Objectives: The objective of the study was to find the frequency of salivarygland tumours. Study Design: A descriptive study. Period: 1st Jan 2008 to 31st Dec 2010 (of 3years duration). Setting: ENT department Khyber Teaching Hospital and Surgical departmentHayatabad Medical Complex, Peshawar. Material and methods: Total number of 108 patientshaving salivary gland tumours enrolled from admitted patients in ENT department KhyberTeaching Hospital and Surgical department Hayatabad Medical Complex Peshawar. Thestudy was designed to find the frequency of salivary gland tumours. Results: In our studymost of the patients were having benign tumours (80.6%) with malignant counterpart in about19.4%. Overall the most common tumour was pleomorphic adenoma about 71.3% followed byMucoepidermoid 6.5%, adenoid cystic carcinoma 4.6% and Warthin’s tumour 4.6%. The mostcommonly involved salivary gland is parotid gland about 78.7% (85/108) with pleomorphicadenoma being the most common benign tumour and Mucoepidermoid the malignant variety.In submandibular gland/ sublingual glands the most common was pleomorphic adenomaand in minor salivary gland majority were malignant. Conclusion: Most of the salivary glandtumours are benign with majority of them are pleomorphic adenomas and parotid gland is themost common involved salivary gland.

S-100 protein localization in minor salivary gland tumours: an aid to diagnosis

1988 ◽  
Vol 102 (10) ◽  
pp. 905-908 ◽  
Author(s):  
J. B. Campbell ◽  
J Crocker ◽  
P. M. Shenoi
Keyword(s):  
Salivary Gland ◽  
Protein Localization ◽  
Minor Salivary Gland ◽  
Staining Reaction ◽  
Major Salivary Gland ◽  
Salivary Gland Tumours ◽  
Pleomorphic Adenomas ◽  
S 100 ◽  
Strong Staining ◽  
Immunohistochemical Techniques

AbstractThe clinician is almost entirely dependent on the histopathologist to accurately diagnose minor salivary gland tumours, but in some cases the histological interpretation of the specimen is very difficult. Recently it has been demonstrated using immunohistochemical techniques that S-100 protein is present in some salivary gland tissues and its localization has been used as an aid in the differentiation of major salivary gland tumours. To assess its value in the diagnosis of minor salivary gland tumours it was localized in sections from 15 such tumours using both a standard peroxidase-antiperoxidase (PAP) and a newly developed immunogold-silver staining sequence (IGSS) technique. Strong staining for S-100 protein was seen in the nuclei and cytoplasm of the cellular areas and also in the cells in the chondroid and myxoid areas of pleomorphic adenomas. Generally the staining was more intense and widespread with the IGSS method. No staining was observed in any of the other tumour types. We conclude that S-100 protein localization is a valuable aid in the differentiation of minor salivary gland tumours. Furthermore, the IGSS method enables more sensitive ‘reading’ of the staining reaction.

Mucoepidermoid carcinoma in a minor salivary gland in childhood

1987 ◽  
Vol 101 (12) ◽  
pp. 1320-1323 ◽  
Author(s):  
Hans Gustafsson ◽  
Åke Dahlqvist ◽  
Matti Anniko ◽  
Bengt Carlsöö
Keyword(s):  
Salivary Gland ◽  
Mucoepidermoid Carcinoma ◽  
Adult Population ◽  
Minor Salivary Gland ◽  
Childhood And Adolescence ◽  
Minor Salivary Glands ◽  
Salivary Gland Tumours ◽  
Pediatric Age Group ◽  
Pleomorphic Adenomas ◽  
A Minor

SummarySalivary gland neoplasms in childhood and adolescence are rare, especially in the minor salivary glands. Vasoformative tumours and pleomorphic adenomas appear to be the most common benign neoplastic salivary gland lesions in the pediatric age group. The distribution of various malignant histological types is not always consistent with that in the adult population, and they appear more often in girls than in boys. Only 17 cases have previously been documented. The clinical and histological picture of a case of palatal mucoepidermoid carcinoma in a 13-year-old girl is presented as well as a review of the literature on malignant salivary gland tumours in childhood.

scholarly journals Soft Palate Pleomorphic Adenoma of a Minor Salivary Gland: An Unusual Presentation

2018 ◽  
Vol 2018 ◽  
pp. 1-4
Author(s):  
C. T. Forde ◽  
R. Millard ◽  
S. Ali
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
Soft Palate ◽  
Minor Salivary Gland ◽  
Operative Management ◽  
General Anaesthetic ◽  
Salivary Gland Tumours ◽  
Pleomorphic Adenomas ◽  
Risk Of Malignancy

Approximately 10% of pleomorphic adenomas occur in the minor salivary glands with the palate being the most common site. Pleomorphic adenomas account for the majority of palatal tumours; however, minor salivary gland tumours have a higher risk of malignancy compared to tumours of the major salivary glands, so appropriate diagnostic evaluation should be prompt. We present a case of a 52-year-old man with a longstanding history of a soft palate pleomorphic adenoma which required excision under general anaesthetic via a mandibular swing approach. As well as the surgical approach to access this tumour; this case is unique as it is the largest soft palate pleomorphic adenoma reported in the literature. We discuss the appropriate preoperative investigations and airway considerations for this patient, as well as the factors to consider when planning operative management of palatal tumours.

Intraluminal crystalloids in malignant salivary gland tumours

1987 ◽  
Vol 101 (11) ◽  
pp. 1175-1181 ◽  
Author(s):  
Jae Y. Ro ◽  
Bruce Mackay ◽  
John G. Batsakis ◽  
Joiner Cartwright
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Parotid Glands ◽  
Salivary Duct ◽  
X Ray ◽  
Salivary Gland Tumours ◽  
Pleomorphic Adenomas

AbstractThe ultrastructural, X-ray microanalytical, histochemical and immunocytochemi-cal features of intraluminal crystalloids found in adenocarcinomas of the parotid gland have been studied. The crystalloids, putatively derived from an abnormal crystalization of salivary duct proteins, are considerably different from the crystalloids found in normal parotid glands, pleomorphic adenomas, and sialocysts.

scholarly journals Minor Salivary Gland Tumours of Upper Aerodigestive Tract: A Clinicopathological Study

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Grażyna Wyszyńska-Pawelec ◽  
Michał Gontarz ◽  
Jan Zapała ◽  
Mariusz Szuta
Keyword(s):  
Salivary Gland ◽  
Minor Salivary Gland ◽  
Relative Survival ◽  
Aerodigestive Tract ◽  
Malignant Tumours ◽  
Upper Aerodigestive Tract ◽  
Female Ratio ◽  
Salivary Gland Tumours ◽  
Results Of Treatment ◽  
Radial Forearm

The aim of this retrospective study of 56 patients with minor salivary gland tumours (MSGTs) of the upper aerodigestive tract is to present demographic features, distribution of tumours as well as methods and results of treatment performed in our institution over a 10-year period. Of 221 patients with salivary gland tumours, 56 patients with MSGT were selected. There were 36 female and 20 male patients aged from 8 to 81 years. Male-to-female ratio was 1 : 2 in the group of benign MSGT and 1 : 1.7 in the group of malignant tumours. The palate was the most frequent site of MSGT (45.6%), followed by buccal mucosa (19.3%). Of all MSGTs 63.2% were malignant, and 36.8% were benign. Adenoid cystic carcinoma was the most common neoplasm (31.6%), followed by pleomorphic adenoma (29.8%). Surgery was the method of choice in the treatment of patients with MSGT. Postoperative defects were reconstructed by prosthetic obturators, local flaps, and free radial forearm flap. Relative survival for patients with malignant MSGT was 88% at three years and 71.5% at five years. MSGTs are more frequent in females and predominantly affect the palate. Malignant MSGTs are more common than benign.

scholarly journals Stereotactic Vacuum-Assisted Breast Biopsy in Ductal Carcinoma in situ: Residual Microcalcifications and Intraoperative Findings

Breast Care ◽  
2019 ◽  
Vol 15 (4) ◽  
pp. 386-391
Author(s):  
Benedict Krischer ◽  
Serafino Forte ◽  
Gad Singer ◽  
Rahel A. Kubik-Huch ◽  
Cornelia Leo
Keyword(s):  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Significant Proportion ◽  
Invasive Cancer ◽  
Histopathological Diagnosis ◽  
Low Grade ◽  
High Grade ◽  
Surgical Specimen

Purpose: The question of overtreatment of ductal carcinoma in situ (DCIS) was raised because a significant proportion of especially low-grade DCIS lesions never progress to invasive cancer. The rationale for the present study was to analyze the value of stereotactic vacuum-assisted biopsy (VAB) for complete removal of DCIS, focusing on the relationship between the absence of residual microcalcifications after stereotactic VAB and the histopathological diagnosis of the definitive surgical specimen. Patients and Methods: Data of 58 consecutive patients diagnosed with DCIS by stereotactic VAB in a single breast center between 2012 and 2017 were analyzed. Patient records from the hospital information system were retrieved, and mammogram reports and images as well as histopathology reports were evaluated. The extent of microcalcifications before and after biopsy as well as the occurrence of DCIS in biopsy and definitive surgical specimens were analyzed and correlated. Results: There was no correlation between the absence of residual microcalcifications in the post-biopsy mammogram and the absence of residual DCIS in the final surgical specimen (p = 0.085). Upstaging to invasive cancer was recorded in 4 cases (13%) but occurred only in the group that had high-grade DCIS on biopsy. Low-grade DCIS was never upgraded to high-grade DCIS in the definitive specimen. Conclusions: The radiological absence of microcalcifications after stereotactic biopsy does not rule out residual DCIS in the final surgical specimen. Since upstaging to invasive cancer is seen in a substantial proportion of high-grade DCIS, the surgical excision of high-grade DCIS should remain the treatment of choice.

scholarly journals Basal Cell Adenoma of the Upper Lip from Minor Salivary Gland Origin

2008 ◽  
Vol 02 (03) ◽  
pp. 213-216 ◽  
Author(s):  
Eliana Maria Minicucci ◽  
Eloisa Bueno Pires de Eloisa ◽  
Silke Anna Thereza Weber ◽  
Maria Aparecida Custodio Domingues ◽  
Daniel Araki Ribeiro
Keyword(s):  
Salivary Gland ◽  
Basal Cell ◽  
Cell Layer ◽  
Minor Salivary Gland ◽  
Salivary Gland Neoplasm ◽  
Basal Cell Adenoma ◽  
Parotid Glands ◽  
Upper Lip ◽  
Basal Cell Layer ◽  
Cell Adenoma

ABSTRACTBasal cell adenoma is an uncommon benign salivary gland neoplasm, presenting isomorphic basaloid cells witha prominent basal cell layer. Taking into account that basal cell adenomas represent 1% of all salivary gland tumors, being the majority of cases in the parotid glands, the goal of this paper is to report a case of basalcell adenoma of the upper lip arising from minor salivary gland. (Eur J Dent 2008;2:213-216)

The Milan System for Reporting Salivary Gland Cytopathology: Assessment of Cytohistological Concordance and Risk of Malignancy

2020 ◽  
pp. 1-13
Author(s):  
Shilpy Jha ◽  
Suvradeep Mitra ◽  
Suvendu Purkait ◽  
Amit Kumar Adhya
Keyword(s):  
Salivary Gland ◽  
Predictive Value ◽  
Malignant Tumors ◽  
Minor Salivary Gland ◽  
Treatment Protocol ◽  
Needle Aspiration ◽  
Histopathological Diagnosis ◽  
Wide Range ◽  
Risk Of Malignancy

<b><i>Introduction:</i></b> The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) was proposed by the American Society of Cytopathology and the International Academy of Cytology to bring uniformity in the reporting system and the treatment protocol. A wide range of risk of malignancy for each category has been reported by various authors by applying the system. <b><i>Aim:</i></b> We intend to study the cytohistological concordance and the ROM for each of the diagnostic categories of the Milan system. <b><i>Materials and Methods:</i></b> The study included 292 cases of fine-needle aspiration cytology (FNAC) of salivary gland lesions over a period of 3 years. The diagnosis of these cases was reclassified into the 6 categories of the Milan system. The cytohistological concordance and ROM for each category of the Milan system were calculated based on the clinical and histopathological follow-up. <b><i>Results:</i></b> The patients’ age ranged from 3 to 81 years with the mean of 42.65 ± 16.3 years. The cases included 189 (64.7%) parotid, 82 (28.1%) submandibular, and 21 (7.2%) cases of minor salivary gland swellings. Follow-up histopathological diagnosis for 102 cases was available. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were calculated to be 64.28, 97.01, 90, 86.67, and 87.37%, respectively. After reclassification, the number of cases in each category was as follows: category I: 31 (10.62%), category II: 80 (27.4%), category III: 2 (0.68%), category IVA: 143 (48.97%), category IVB: 1 (0.34%), category V: 13 (4.45%), and category VI: 22 (7.53%). The calculated ROM was as follows: category I: 42.86%, category II: 26.67%, category III: 100% category IVA: 10.17%, category IVB: 0%, category V: 71.42%, category VI: 100%. <b><i>Conclusion:</i></b> FNAC is an excellent procedure to differentiate benign from malignant tumors, and MSRSGC is a useful system for risk assessment and deciding the further treatment protocol. Our findings also suggest that in addition to the surgical follow-up, inclusion of the clinical and radiological follow-up may be a better strategy for calculation of ROM, especially for categories I and II.

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