Relationship between macular vessel density and central visual field sensitivity at different glaucoma stages

2019 ◽  
pp. bjophthalmol-2018-313019
Author(s):  
Joong Won Shin ◽  
Jiyun Lee ◽  
Junki Kwon ◽  
Younhye Jo ◽  
Daun Jeong ◽  
...  
Keyword(s):  
Visual Field ◽  
Structure Function ◽  
Early Stage ◽  
Plexiform Layer ◽  
Vessel Density ◽  
Inner Plexiform Layer ◽  
Central Visual Field ◽  
Field Sensitivity ◽  
Advanced Glaucoma ◽  
Function Relationship

AimsTo evaluate the relationship between macular vessel density (mVD) and central visual field sensitivity (cVFS) at different stages of glaucoma and to compare this relationship with that between the thickness of the macular ganglion cell-inner plexiform layer (mGCIPLT) and cVFS.MethodsThe mVD and mGCIPLT were measured by optical coherence tomography angiography in 139 patients with glaucoma. The cVFS was defined as the average of 12 central points on 24-2 visual field (VF) testing. Vasculature–function and structure–function relationships were analysed by comparing mVD and mGCIPLT with cVFS in eyes with early and moderate-to-advanced glaucoma.ResultsGlobal and regional mVD–cVFS associations were statistically significant in eyes with moderate-to-advanced (all p<0.05), but not early stage (all p>0.05) glaucoma. The global association between average mVD and cVFS was significantly stronger than that between average mGCIPLT and cVFS in eyes with moderate-to-advanced glaucoma (p=0.049). Reduced mVD was independently associated with cVFS loss after adjusting for age and mGCIPLT in eyes with moderate-to-advanced glaucoma.ConclusionsThe macular vasculature–function relationship using mVD was stronger than the structure–function relationship using mGCIPLT in eyes with moderate-to-advanced glaucoma. The mVD may be useful in monitoring cVFS in advanced glaucoma.

scholarly journals Simultaneously performed combined 24-2 and 10-2 visual field tests in glaucoma

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kyoung In Jung ◽  
Hee Kyung Ryu ◽  
Ki Hoon Hong ◽  
Yong Chan Kim ◽  
Chan Kee Park
Keyword(s):  
Visual Field ◽  
Structure Function ◽  
Field Tests ◽  
Plexiform Layer ◽  
Inner Plexiform Layer ◽  
Fiber Layer ◽  
Structure Function Relationship ◽  
Paracentral Scotoma ◽  
Function Relationship ◽  
Topographic Structure

AbstractUsing either 24-2 or 10-2 visual field (VF) testing only is not enough to cover all the various types of glaucomatous VF defects. We investigated the performance of the combined 24-2 and 10-2 perimetry when conducted together and separately using the structure–function relationship. A total of 30 glaucoma patients with isolated peripheral nasal step, 37 patients with isolated paracentral scotoma, and 38 patients with both paracentral and nasal scotoma were included. To create the combined Humphrey VF test, a custom test pattern was established using the built-in custom point options, an example of the X, Y coordinate system. In glaucoma patients with peripheral nasal step, the superotemporal topographic structure–function relationship with peripapillary retinal nerve fiber layer (RNFL) thickness was superior in relation to the combined or 24-2 perimetry relative to the 10-2 perimetry (both P < 0.05). The combined VF test showed more favorable inferotemporal or inferonasal structure–function correlation with the corresponding ganglion cell–inner plexiform layer (GCIPL) thickness when compared with results gleaned using the 24-2 VF test (P < 0.05). Simultaneously performed 24-2 and 10-2 VF tests demonstrated a superior topographic structure–function relationship when compared with them separately performed in some sectors.

Glaucoma diagnostic capabilities of macular vessel density on optical coherence tomography angiography: superficial versus deep layers

2021 ◽  
pp. bjophthalmol-2020-318449
Author(s):  
Jin Yeong Lee ◽  
Joong Won Shin ◽  
Min Kyung Song ◽  
Ji Wook Hong ◽  
Michael S Kook
Keyword(s):  
Optical Coherence Tomography ◽  
Open Angle Glaucoma ◽  
Plexiform Layer ◽  
Vessel Density ◽  
Inner Plexiform Layer ◽  
Optical Coherence ◽  
Central Visual Field ◽  
Deep Layers ◽  
Diagnostic Capabilities ◽  
Better Than

Background/aimsTo compare glaucoma diagnostic capabilities of superficial and deep macular vessel density (mVD) parameters in a series of healthy and open-angle glaucoma (OAG) eyes with central visual field (CVF) loss.MethodsWe consecutively enrolled 113 eyes of 113 patients with OAG and 47 eyes of 47 healthy participants in a retrospective manner. Superficial and deep mVDs were measured at foveal, parafoveal and perifoveal locations on optical coherence tomography (OCT) angiography. The macular ganglion cell-inner plexiform layer thickness (mGCIPLT) was measured on OCT as a reference standard. Glaucoma diagnostic capabilities of superficial and deep mVD parameters were assessed according to the glaucoma stage. Factors associated with the CVF mean sensitivity (MS) were evaluated using linear regression analyses in the OAG eyes.ResultsGlaucoma diagnostic capabilities of superficial perifoveal and parafoveal mVDs were significantly better than those of deep perifoveal and parafoveal mVDs, regardless of the glaucoma stage (both p<0.05). Both mGCIPLT and superficial parafoveal mVD were significantly associated with CVF MS (β-coefficients=10.567 and 21.147, respectively, both p<0.05), independent of age and glaucoma severity.ConclusionSuperficial mVD parameters showed significantly greater glaucoma diagnostic capabilities and better correlation with CVF MS compared with deep mVD parameters.

Structure-Function Relationship Between the Bruch Membrane Opening-based Minimum Rim Width and Visual Field Defects in Advanced Glaucoma

2017 ◽  
Vol 26 (6) ◽  
pp. 561-565 ◽  
Author(s):  
Serhat Imamoglu ◽  
Nimet Burcu Celik ◽  
Mehmet S. Sevim ◽  
Gokhan Pekel ◽  
Nimet Yesim Ercalik ◽  
...  
Keyword(s):  
Visual Field ◽  
Structure Function ◽  
Visual Field Defects ◽  
Structure Function Relationship ◽  
Advanced Glaucoma ◽  
Function Relationship ◽  
Field Defects

Structure–Function Relationship in Glaucoma Using Ganglion Cell–Inner Plexiform Layer Thickness Measurements

2015 ◽  
Vol 56 (6) ◽  
pp. 3883 ◽  
Author(s):  
Harsha L. Rao ◽  
Muhammad Qasim ◽  
Raza S. M. Hussain ◽  
Manideepak Januwada ◽  
Lalitha N. Pillutla ◽  
...  
Keyword(s):  
Structure Function ◽  
Ganglion Cell ◽  
Layer Thickness ◽  
Plexiform Layer ◽  
Inner Plexiform Layer ◽  
Structure Function Relationship ◽  
Function Relationship ◽  
Thickness Measurements
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