scholarly journals Fractal analysis of polypoidal choroidal neovascularisation in age-related macular degeneration

2020 ◽  
pp. bjophthalmol-2020-317011
Author(s):  
Rita Serra ◽  
Florence Coscas ◽  
Antonio Pinna ◽  
Diogo Cabral ◽  
Gabriel Coscas ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Macular Degeneration ◽  
Fractal Analysis ◽  
Choroidal Neovascularisation ◽  
Age Related Macular Degeneration ◽  
Ophthalmological Examination ◽  
Optical Coherence ◽  
Vascular Perfusion ◽  
Age Related ◽  
Significant Difference

AimTo describe optical coherence tomography angiography (OCTA) features of polypoidal choroidal neovascularisation (PCNV) secondary to age-related macular degeneration.MethodsA retrospective consecutive series of 51 patients with a diagnosis of PCNV, based on clinical and multimodal imaging, was analysed. All patients with PCNV underwent a comprehensive ophthalmological examination, including fluorescein and indocyanine green angiography, structural optical coherence tomography (OCT) and OCTA. Two blinded retinal specialists carefully reviewed OCTA slabs in order to assess the morphological patterns of PCNV lesions. Furthermore, fractal analysis of PCNV en face images on OCTA, including vascular perfusion density (VPD), fractal dimension (FD) and lacunarity (LAC), was performed.ResultsFifty-one PCNV eyes were included in the study. In all, the branching vascular network appeared hyper-reflective. Polyps showed two different patterns: in 34/51 (67%) eyes, they corresponded to hypo-reflective structures, whereas in the remaining 17 (33%) eyes, they appeared as hyper-reflective lesions. In all PCNV eyes, mean VPD, FD and LAC were 0.76±0.17%, 1.46±0.12 and 2.4±0.87, respectively. No significant difference was found between PCNVs showing a different OCTA pattern, in terms of quantitative OCTA parameters.ConclusionFractal analysis provides quantitative parameters demonstrating that PCNVs with different OCTA patterns share the same neovascular architecture and branching complexity. These new findings improve our ability to interpret OCTA slabs, opening new areas of discussion about this type of neovascular lesion.

scholarly journals Quantitative analysis of optical coherence tomography in age related macular degeneration

2021 ◽  
Vol 7 (2) ◽  
pp. 372-375
Author(s):  
D Sukanya ◽  
R Sudha ◽  
K Sushma ◽  
V Sreya
Keyword(s):  
Optical Coherence Tomography ◽  
Macular Degeneration ◽  
Tertiary Care ◽  
Age Related Macular Degeneration ◽  
Optical Coherence ◽  
Tertiary Care Centre ◽  
Age Related ◽  
Macular Diseases ◽  
Significant Difference ◽  
Degenerative Disorder

Age related macular degeneration (ARMD) is a common degenerative disorder of macula in people above 50 years. The dry and wet/neovascular forms can lead to loss of vision. Optical coherence tomography is a popular tool in the diagnosis of AMRD. Aim of the study is to assess the Optical Coherence Tomography to diagnose the Age Related Macular Degeneration in a tertiary care centre. This prospective hospital based study was conducted on 50 patients presenting with age related macular degeneration clinically (100 eyes). Inclusion criteria was patients newly diagnosed clinically as ARMD and on no treatment. Exclusion criteria was Patients already diagnosed ARMD and on treatment, Patients with other retinal and macular diseases, and previous laser treatment. There were 42(84%) of patients are of 50-70 years age. Males were 21, and females were 29 without significant difference (p=0.7). Out of 100 eyes, 32% diagnosed as wet ARMD and 60% eyes had dry ARMD Dry ARMD is common in females (34%) and wet ARMD common in males (26%). In dry ARMD cases, 77.04% eyes had drusen by OCT, and 72.72% eyes had classic Choroidal neovascular membranes (CNVM). OCT showed sub-foveal CNVM as the common type of classic CNVM. 16 men were smokers, and 36 patients have hypertension. Smoking was significantly associated with ARMD (P < 0.05). Increased prevalence of wet ARMD in males due to smoking, which leads to risk for CNVM. Smoking was significantly associated with ARMD (P < 0.01) in our study. The prevalence was increased with increasing age. Dry ARMD was much more common than Wet ARMD, and both types increased in frequency with increasing age. ARMD is more common in females. OCT is highly specific in detecting the early sub-retinal neo vascular membrane and to assess the activity of neovascular membranes in early wet ARMD.

scholarly journals Effect of total anti-VEGF treatment exposure on patterns of choroidal neovascularisation assessed by optical coherence tomography angiography in age-related macular degeneration: a retrospective case series

2019 ◽  
Vol 4 (1) ◽  
pp. e000244 ◽  
Author(s):  
Livia Faes ◽  
Zaria Ali ◽  
Siegfried Wagner ◽  
Praveen J Patel ◽  
Dun Jack Fu ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Macular Degeneration ◽  
Optical Coherence Tomography Angiography ◽  
Case Series ◽  
Choroidal Neovascularisation ◽  
Age Related Macular Degeneration ◽  
Optical Coherence ◽  
Retrospective Case ◽  
Age Related ◽  
The Mean

ObjectiveTo compare clinical characteristics of patients suffering from neovascular age-related macular degeneration (nAMD) with mature and immature choroidal neovascularisation (CNV) as assessed by optical coherence tomography angiography (OCTA). To explore the effect of total anti-vascular endothelial growth factor exposure on the occurrence of mature CNV when correcting for potential confounders.Methods and analysisIn this retrospective case series, we included 40 eyes of 36 patients with nAMD with CNV assessed by OCTA at the Manchester Eye Hospital between June 2016 and June 2017. A retinal specialist masked to patient information graded CNV depicted on OCTA scans. For statistical comparisons, we used t-tests, Fisher’s exact tests and a mixed-effects logistic regression model.Results18 patients (20 eyes) were treatment naïve, and the mean number of intravitreal injections (IVI) in the remaining eyes was 18.4 (range 2–71). The mean duration of nAMD was 19.3 months (range 0–87.4). 25 eyes (62.5%) exhibited mature CNV. Eyes with mature CNV did not differ from those with immature CNV regarding age (+2.8 years; p=0.288) or duration of disease (+9.4 months; p=0.061). However, they had a higher number of IVIs (+3.1; p=0.035). Among eyes with best corrected visual acuity over 25 letters, there was a strong association between the number of IVIs (0 vs 1–20: OR 68.01 [95% CI 1.30 to 3546.99; p=0.036], 0 vs >20 IVI: OR 380.01 [95% CI 2.60 to 55 464.89; p=0.019]) and maturity status when correcting for potential confounders.ConclusionMaturity status of CNV as assessed by OCTA may indicate treatment exposure of CNV in nAMD.

Optical coherence tomography angiography reproducibility of lesion size measurements in neovascular age-related macular degeneration (AMD)

2017 ◽  
Vol 102 (6) ◽  
pp. 821-826 ◽  
Author(s):  
Francesca Amoroso ◽  
Alexandra Miere ◽  
Oudy Semoun ◽  
Camille Jung ◽  
Vittorio Capuano ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Macular Degeneration ◽  
Optical Coherence Tomography Angiography ◽  
Automatic Segmentation ◽  
Choroidal Neovascularisation ◽  
Age Related Macular Degeneration ◽  
Optical Coherence ◽  
Lesion Area ◽  
Vessel Area ◽  
Age Related

PurposeTo evaluate the reproducibility and interuser agreement of measurements of choroidal neovascularisation in optical coherence tomography angiography (OCTA).DesignProspective non-interventional study.MethodsConsecutive patients, presenting with neovascular age-related macular degeneration (AMD), underwent two sequential OCTA examinations (AngioVue, Optovue, Fremont, California, USA), performed by the same trained examiner. Neovascular lesion area was then measured on both examinations in the choriocapillaris automatic segmentation by two masked readers, using the semiautomated measuring software embedded in the instrument. Two measuring features were used: the first corresponding to the total manually contoured lesion area with the flow draw tool (select area) and the second to the total area of solely vessels with high flow within the lesion (vessel area). These measurements were then compared in order to assess both the reproducibility of OCTA examination and the interuser agreement with the embedded software.ResultsForty-eight eyes of 46 patients (77.4 mean age,+/-8.2 SD, range from 62 to 95 years old, eight men, 38 women) were included in our study. Mean choroidal neovascularisation area was of 0.72+/-0.7 mm2 for the first measurement and 0.75+/-0.76 mm2 for the second measurement; difference between the first and the second measurement was 0.03 mm2. Intrauser agreement was of 0.98 (CI 0.98 to 0.99) for both ‘vessel area’ and ‘select area’ features. Interuser agreement was of 0.98 (CI 0.97 to 0.99) for ‘select area’ and ‘vessel area’ features.ConclusionOur data suggest that OCTA provide reproducible imaging for evaluation of the neovascular size in the setting of AMD.

A Comparison of Radial and Horizontal Macular Optical Coherence Tomography on Detection of Macular Pathology: A Prospective Study at an Academic Institution

2021 ◽  
pp. 247412642199705
Author(s):  
Halward M.J. Blegen ◽  
Samuel D. Hobbs ◽  
Reggie Taylor ◽  
Andrew L. Plaster ◽  
Paul M. Drayna
Keyword(s):  
Optical Coherence Tomography ◽  
Prospective Study ◽  
Macular Degeneration ◽  
Epiretinal Membrane ◽  
Central Serous Chorioretinopathy ◽  
Age Related Macular Degeneration ◽  
Optical Coherence ◽  
Age Related ◽  
Macular Diseases ◽  
A Prospective Study

Purpose: Optical coherence tomography (OCT) is useful in diagnosing and monitoring retinal pathology such as age-related macular degeneration, diabetic macular edema (DME), central serous chorioretinopathy, and epiretinal membrane, among others. This study compared the ability of horizontal (H) 25-, 13-, and 7-cut macular OCT vs 24-, 12-, and 6-cut radial (R) macular OCT in identifying various macular pathology. Methods: This was a prospective study of 161 established patients evaluated at Wilford Hall Eye Center Retina Clinic between September and October of 2019. Pathology included age-related macular degeneration, central serous chorioretinopathy, DME, and epiretinal membrane, among others. Patients obtained 25-, 13-, and 7-cut H raster OCT as well as 24-, 12-, and 6-cut R OCT. Primary outcomes were sensitivity in detecting macular fluid and each macular abnormality. Results: The 24-cut radial (R24) OCT equally or out-performed the H25 (horizontal 25-cut OCT) in detecting macular fluid across all pathological groups. Generally, a higher number of cuts correlated with better detection of fluid. In detecting any macular abnormalities, H25, R24, and R12 had 100% sensitivity. R6 OCT had near 100% sensitivity across all groups, except for DME (95%). Overall, R OCT had better sensitivity (0.960) than H OCT (0.907) in detecting macular pathology. Conclusions: R outperformed H macular OCT in detecting fluid and other abnormalities. Clinically, both scanning patterns can be used by ophthalmologists in diagnosis and management of commonly encountered macular diseases. Technicians may be able to use a variety of these scans to screen for pathology prior to physician evaluation.

scholarly journals The Spectrum of Central Choriocapillaris Abnormalities on Swept-Source Optical Coherence Tomography Angiography in the Fellow Eye of Unilateral Exudative Age-Related Macular Degeneration Patients: From Flow Deficits to Subclinical Non-Exudative Neovascularization

2021 ◽  
Vol 10 (12) ◽  
pp. 2658
Author(s):  
Alexis Khorrami Kashi ◽  
Eric Souied ◽  
Selim Fares ◽  
Enrico Borrelli ◽  
Vittorio Capuano ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Macular Degeneration ◽  
Optical Coherence Tomography Angiography ◽  
Clinical Findings ◽  
Age Related Macular Degeneration ◽  
Optical Coherence ◽  
Swept Source ◽  
Exudative Amd ◽  
Age Related ◽  
Fellow Eyes

We evaluated the spectrum of choriocapillaris (CC) abnormalities in the fellow eyes of unilateral exudative age-related macular degeneration (AMD) patients using swept-source optical coherence tomography angiography (SS-OCTA). Fellow eyes of unilateral exudative AMD patients were prospectively included between May 2018 and October 2018. Patients underwent a multimodal imaging including a SS-OCTA. Demographics and clinical findings were analyzed. The estimated prevalence of macular neovascularization (MNV) was computed. Number and size of flow deficits (FDs) and percentage of flow deficits (FD%) were computed on the compensated CC flow images with the Fiji software. We included 97 eyes of 97 patients (mean age was 80 ± 7.66 years, 39 males, 58 females). The prevalence of MNV in the studied eyes was 8.25% (8/97 eyes). In the 89 non-neovascular eyes, FD% averaged 45.84% ± 11.63%, with a corresponding total area of FDs of 4.19 ± 1.12 mm2. There was a higher prevalence of drusenoid pigment epithelial detachment in eyes with subclinical neovascularization (p = 0.021). Fellow eyes with unilateral exudative AMD encompassed a series of CC abnormalities, from FDs of the aging CC to subclinical non-exudative MNV.

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