scholarly journals An Address on the Early Recognition of General Paralysis of the Insane, and the Relations between this Disease, Tabes Dorsalis, and Disseminated Sclerosis

BMJ ◽  
1887 ◽  
Vol 1 (1357) ◽  
pp. 1-5
Author(s):  
J. S. Bristowe
Keyword(s):  
Early Recognition ◽  
General Paralysis ◽  
Tabes Dorsalis ◽  
Disseminated Sclerosis

Mental Disease (not General Paralysis) associated with Tabes Dorsalis

1897 ◽  
Vol 43 (180) ◽  
pp. 63-67
Author(s):  
P. W. Macdonald ◽  
A. Davidson
Keyword(s):  
Mental Disease ◽  
General Paralysis ◽  
Tabes Dorsalis ◽  
Mental Symptoms ◽  
Nerve Tracts

The object of this paper is not so much to relate anything that is new as to show that mental symptoms are not always easy of classification when associated with organic changes in nerve tracts outside the cerebral cavity.

Routine Treatment of Epilepsy

1929 ◽  
Vol 75 (308) ◽  
pp. 107-113
Author(s):  
John P. Steel
Keyword(s):  
Blood Pressure ◽  
Differential Diagnosis ◽  
High Blood Pressure ◽  
List Type ◽  
Type Number ◽  
Routine Treatment ◽  
General Paralysis ◽  
Treatment Of Epilepsy ◽  
Tabes Dorsalis

In this hospital we have a routine differential diagnosis which is applied in all cases of suspected epilepsy and which is as follows: (a)High blood-pressure.(b)Trauma of vessels and angiospasm.(c)Nephritis, subacute and chronic.(d)Diabetes.(e)Tabes dorsalis, tabo-paresis, neuro-syphilis and general paralysis.(f)Hysteria.(g)Epilepsy.

scholarly journals The Bearing of Recent Research in the Posterior Root Ganglia upon the New Theories concerning the Ætiology of Tabes dorsalis

1902 ◽  
Vol 48 (201) ◽  
pp. 308-312
Author(s):  
R. G. Rows
Keyword(s):  
Spinal Cord ◽  
Degenerative Changes ◽  
Posterior Root ◽  
Normal Cells ◽  
General Paralysis ◽  
Tabes Dorsalis ◽  
The Subject ◽  
Posterior Root Ganglia

Dr. Orr has shown you the normal cells of the posterior root ganglia and the changes which they undergo in general paralysis of the insane, and we have thought that it would be of some interest briefly to follow the subject a little further, and to see what is the modem view of the degenerative changes in the cells of the posterior root ganglia and in the nervefibres of the spinal cord in general paralysis and in tabes dorsalis.

TABES DORSALIS IN THE POST ANTIBIOTIC ERA: NEVER SAY NEVER

2015 ◽  
Vol 86 (11) ◽  
pp. e4.123-e4
Author(s):  
Chinar Osman ◽  
Tristan Clark ◽  
Boyd Ghosh ◽  
Christopher Halfpenny
Keyword(s):  
Urinary Incontinence ◽  
Early Recognition ◽  
Undetectable Viral Load ◽  
Dorsal Column ◽  
High Signal ◽  
Appropriate Treatment ◽  
Tabes Dorsalis ◽  
History Of ◽  
Whole Spine

BackgroundTabes dorsalis is a neurological form of tertiary syphilis and is considered to be rare in the post antibiotic era. It results from damage to nerve cells in the dorsal column and roots of the spinal cord. It is characterised by sensory ataxia, lightening pains and urinary incontinence. If left untreated it can progress to paralysis and dementia.Case summaryWe present the case of an HIV positive 47 year old male with a CD4 count of 400 and an undetectable viral load on HAART. He presented with an 8 month history of progressively severe lightening pains, gait disturbance, tinnitus, hearing loss, and urinary incontinence. He had a positive plasma VDRL with a titre of 1:32, and his CSF was VDRL positive. Whole spine MRI scan demonstrated high signal in the dorsal cord with associated atrophy. He was treated with intravenous benzylpenicillin 2.4 grams 4 hourly for 14 days. Follow up at 4 and 8 months demonstrated marked clinical improvement with a falling serum VRDL titre. Repeat LP at 6 month post treatment demonstrated VDRL negativity.DiscussionTabes Dorsalis may still occur in the post antibiotic era. Early recognition and appropriate treatment can lead to good clinical outcomes.

scholarly journals The chemistry of nerve-degeneration

1901 ◽  
Vol 68 (442-450) ◽  
pp. 149-151
Keyword(s):  
Spinal Fluid ◽  
Nerve Degeneration ◽  
General Paralysis ◽  
The Brain ◽  
Disseminated Sclerosis

We have previously shown that in the disease, General Paralysis of the Insane, the marked degeneration that occurs in the brain is accompanied by the passing of the products of degeneration into the cerebro-spinal fluid. Of these, nucleo-proteid and choline are those which can be most readily detected. Choline can also be found in the blood. We have continued our work, and we find that this is not peculiar to the disease just mentioned, but that in various other degenerative nervous diseases (combined sclerosis, disseminated sclerosis, alcoholic neuritis, beri-beri) choline can also be detected in the blood.

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