Childhood adversities and mental disorders in first-year college students: results from the World Mental Health International College Student Initiative

Background This study investigates associations of several dimensions of childhood adversities (CAs) with lifetime mental disorders, 12-month disorder persistence, and impairment among incoming college students. Methods Data come from the World Mental Health International College Student Initiative (WMH-ICS). Web-based surveys conducted in nine countries (n = 20 427) assessed lifetime and 12-month mental disorders, 12-month role impairment, and seven types of CAs occurring before the age of 18: parental psychopathology, emotional, physical, and sexual abuse, neglect, bullying victimization, and dating violence. Poisson regressions estimated associations using three dimensions of CA exposure: type, number, and frequency. Results Overall, 75.8% of students reported exposure to at least one CA. In multivariate regression models, lifetime onset and 12-month mood, anxiety, and substance use disorders were all associated with either the type, number, or frequency of CAs. In contrast, none of these associations was significant when predicting disorder persistence. Of the three CA dimensions examined, only frequency was associated with severe role impairment among students with 12-month disorders. Population-attributable risk simulations suggest that 18.7–57.5% of 12-month disorders and 16.3% of severe role impairment among those with disorders were associated with these CAs. Conclusion CAs are associated with an elevated risk of onset and impairment among 12-month cases of diverse mental disorders but are not involved in disorder persistence. Future research on the associations of CAs with psychopathology should include fine-grained assessments of CA exposure and attempt to trace out modifiable intervention targets linked to mechanisms of associations with lifetime psychopathology and burden of 12-month mental disorders.

First principle study and Hirshfeld surface analysis on the effect of type, number, and position of small molecules on the structural stability and optical property of a powerful energetic crystal 6-nitro-7-azido-pyrazol[3,4-d][1,2,3]triazine-2-oxide

The powerful but unstable high energy compound ICM-103 is stabilized and desensitized by small molecules H2O, NH3, and H2S.

How can psychotherapists improve their practice with service users from minoritised ethnicities? An application of the Declarative-Procedural-Reflective (DPR) model of clinical skill development

Many white psychotherapists may lack the skills required to work effectively with service users from minoritised ethnicities. This article proposes that the nature of this skills deficit can be understood through applying the Declarative-Procedural-Reflective (DPR) model of therapist skill development. The DPR model has been used in a range of psychotherapeutic contexts, and it provides a systematic account of how therapists from all modalities develop and can improve their skills. Adapting this model to white therapists’ skills in working with service users from minoritised ethnicities allows the identification of specific areas of skills deficit, and therefore clear recommendations as to how to address those deficits. The application of the DPR model to this context suggests that there are clear areas of skills deficit in terms of knowledge base, the practical skills of carrying out therapy, and the ability of therapists to reflect on their work with service users from minoritised ethnicities. I conclude by making a number of suggestions as to how those deficits could be addressed, both by individual therapists and at a systemic level. Key learning aims (1) To explore why some white psychotherapists find it more difficult to work effectively with service users from minoritised ethnicities. (2) To conceptualise difficulties in working with service users from minoritised ethnicities as an issue of clinical skill, knowledge and attitude development, where therapists’ skills can be improved if specific deficits are appropriately addressed. (3) To use the structure of the DPR model to better understand how deficits in therapists’ skills, knowledge and reflective ability may have an impact on their work with service users from minoritised ethnicities. This allows the identification of specific areas of deficit, and therefore clear recommendations as to how to address those deficits. (4) This is primarily addressed at CBT therapists, but the points raised in this article apply to all schools of therapy.

Separating minimal valuations, point-continuous valuations, and continuous valuations

We give two concrete examples of continuous valuations on dcpo’s to separate minimal valuations, point-continuous valuations, and continuous valuations: (1) Let ${\mathcal J}$ be the Johnstone’s non-sober dcpo, and μ be the continuous valuation on ${\mathcal J}$ with μ(U)=1 for nonempty Scott opens U and μ(U)=0 for $U=\emptyset$ . Then, μ is a point-continuous valuation on ${\mathcal J}$ that is not minimal. (2) Lebesgue measure extends to a measure on the Sorgenfrey line $\mathbb{R}_\ell$ . Its restriction to the open subsets of $\mathbb{R}_\ell$ is a continuous valuation λ. Then, its image valuation $\overline\lambda$ through the embedding of $\mathbb{R}_\ell$ into its Smyth powerdomain $\mathcal{Q}\mathbb{R}_\ell$ in the Scott topology is a continuous valuation that is not point-continuous. We believe that our construction $\overline\lambda$ might be useful in giving counterexamples displaying the failure of the general Fubini-type equations on dcpo’s.

Mars: new insights and unresolved questions

Mars exploration motivates the search for extraterrestrial life, the development of space technologies, and the design of human missions and habitations. Here, we seek new insights and pose unresolved questions relating to the natural history of Mars, habitability, robotic and human exploration, planetary protection, and the impacts on human society. Key observations and findings include: – high escape rates of early Mars' atmosphere, including loss of water, impact present-day habitability; – putative fossils on Mars will likely be ambiguous biomarkers for life; – microbial contamination resulting from human habitation is unavoidable; and – based on Mars' current planetary protection category, robotic payload(s) should characterize the local martian environment for any life-forms prior to human habitation. Some of the outstanding questions are: – which interpretation of the hemispheric dichotomy of the planet is correct; – to what degree did deep-penetrating faults transport subsurface liquids to Mars' surface; – in what abundance are carbonates formed by atmospheric processes; – what properties of martian meteorites could be used to constrain their source locations; – the origin(s) of organic macromolecules; – was/is Mars inhabited; – how can missions designed to uncover microbial activity in the subsurface eliminate potential false positives caused by microbial contaminants from Earth; – how can we ensure that humans and microbes form a stable and benign biosphere; and – should humans relate to putative extraterrestrial life from a biocentric viewpoint (preservation of all biology), or anthropocentric viewpoint of expanding habitation of space? Studies of Mars' evolution can shed light on the habitability of extrasolar planets. In addition, Mars exploration can drive future policy developments and confirm (or put into question) the feasibility and/or extent of human habitability of space.

Audit Report Lag. Differential Analysis between Spanish SMEs and Non-SMEs

Audit report lag is considered to be an indicator of audit punctuality and efficiency, while the existence of factors that may determine this lag has been signalled in previous studies. The objective of this study is to identify the determinants of audit report lag in Spanish SMEs, and to analyse the potential singularities of these factors with regards to non-SMEs. With this aim in mind, a set of factors has been analysed; in the previous literature, a relationship has been observed between these factors and the characteristics of the audited company, the auditor and the audit exercise. Additionally, the possible influence of financial crisis and recovery periods is analysed. The sample analysed is made up of 3217 unlisted Spanish firms for the years 2008–2015. Multiple linear regression analysis is used, modelling the audit report lag based on the independent variables related to the characteristics of the audited company, the auditor and the audit exercise. Based on the results obtained, we can support the existence of differences among the independent variables responsible for the audit report lag based on company type (SME/non-SME), with a larger number of factors impacting the audit report lag in SMEs. It is worth noting the significant relationship between audit report lag and opinion and crisis variables, both for the SME and non-SME models. In the case of SMEs, links between audit report lag and the likelihood of bankruptcy, auditor type, number of economic activities carried out by the audited company, the industry to which the audited company pertains, and audit fees were also observed. Furthermore, we can conclude that audit report lag is greater in SMEs and that the independent variables explaining report lag differ according to whether the company is an SME or not.

Central Venous Catheter Salvage in Ambulatory Central Line–Associated Bloodstream Infections

BACKGROUND Guidelines for treatment of central line–associated bloodstream infection (CLABSI) recommend removing central venous catheters (CVCs) in many cases. Clinicians must balance these recommendations with the difficulty of obtaining alternate access and subjecting patients to additional procedures. In this study, we evaluated CVC salvage in pediatric patients with ambulatory CLABSI and associated risk factors for treatment failure. METHODS This study was a secondary analysis of 466 ambulatory CLABSIs in patients <22 years old who presented to 5 pediatric medical centers from 2010 to 2015. We defined attempted CVC salvage as a CVC left in place ≥3 days after a positive blood culture result. Salvage failure was removal of the CVC ≥3 days after CLABSI. Successful salvage was treatment of CLABSI without removal of the CVC. Bivariate and multivariable logistic regression analyses were used to test associations between risk factors and attempted and successful salvage. RESULTS A total of 460 ambulatory CLABSIs were included in our analysis. CVC salvage was attempted in 379 (82.3%) cases. Underlying diagnosis, CVC type, number of lumens, and absence of candidemia were associated with attempted salvage. Salvage was successful in 287 (75.7%) attempted cases. Underlying diagnosis, CVC type, number of lumens, and absence of candidemia were associated with successful salvage. In patients with malignancy, neutropenia within 30 days before CLABSI was significantly associated with both attempted salvage and successful salvage. CONCLUSIONS CVC salvage was often attempted and was frequently successful in ambulatory pediatric patients presenting with CLABSI.

ThamRobot: An Automated Robotic System to Play Thammattama

Sri Lanka has a precious traditional drum music culture that is mainly based on traditional drums. At present, this drum culture is in decline due to a lack of talented drum players. As a result, many Buddhist temples are facing a serious and tragic problem. This article presents the design and implementation of a robotic system named ThamRobot contains two robotic arms that were designed to play pre-programmed three drum tunes of the Thammattama correctly and efficiently like a drum player without any intervention of a human. In the research, nine major characteristics factors of the Thammattama such as music notes, drum locations, approximate stress, frequencies, pitch, drum type, number of sticks, playing technique, distance from stick to drum face were identified. The entire system is comprised of four main modules named motion module, user-operation module, processing module, power supply module. Finally, the system has been tested in a laboratory environment and encouraging results were obtained.

Experimental Investigation on Axial Compression of Resilient Nail-Cross-Laminated Timber Panels

Conventional cross-laminated timber is an engineered wood product consisting of solid-sawn lumber panels glued together. In this study, the structural behavior of solid wood panels of Nail-Cross-Laminated Timber (NCLT) panels connected with nails instead of glue was studied. The failure mode and nail deformation of the novel NCLT panels under axial compression load using eight full-scale NCLT panels was investigated. The effects of four key design parameters, namely, the nail type, number of nails, nail orientation angle, and nail slenderness ratio on axial compression performance of NCLT panels were also analyzed. In addition, a formula for predicting the axial compression bearing capacity of NCLT panels was developed. For calculation of the slenderness ratio, the moment of inertia of the full section or the effective section was determined based on the nail type, number of nails, angle of nail orientation and number of layers of the plate. Results showed that specimens connected by tapping screws had best compressive performance.

Jeevan Jyoti Mobile Application for Ambulance Service

In these modern times where the technologies is evolving every day. In order to cope up with the need of proper ambulance services during medical emergency situation, an android mobile application named Jeevan Jyoti is introduced which will aim successful booking of ambulance with required medical support both in the ambulance and from the hospital. Mobile application is a growing and in-demand technology because of its easier accessibility and feasibility to remind users about the upcoming updates with the help of push notification. This idea approaches a system where whenever a request for ambulance is raised, it sends that request to all the nearby hospital(s) along with the parameters such as ambulance type, number of casualties, symptoms, medical report, etc. To expand this system, IoT is added which will help the doctor monitor the vital stats such as pulse rate and temperature of the patient continuously while the ambulance is en-route to the hospital.