scholarly journals Severe ulcerative oesophagitis caused by primary Epstein-Barr virus infection in an immunocompetent individual

2021 ◽  
Vol 8 (1) ◽  
pp. e000586
Author(s):  
Ruben Due Lorentsen ◽  
Louise Laurberg Klarskov ◽  
Casper Steenholdt
Keyword(s):  
Infectious Mononucleosis ◽  
Epstein Barr Virus ◽  
Epigastric Pain ◽  
Immunocompetent Patient ◽  
Pcr Analysis ◽  
Epstein Barr Virus Infection ◽  
Barr Virus ◽  
Epstein Barr ◽  
Barr Virus Infection ◽  
Systemic Symptoms

Epstein-Barr virus (EBV) infects the vast majority of the human population. The primary infection in immunocompetent individuals is typically asymptomatic or presenting as infectious mononucleosis. Here, an 18-year-old man without medical history was admitted with mild non-specific symptoms of infection presenting primarily with severe dysphagia and epigastric pain. Gastroscopy revealed severe, extensive, ulcerative oesophagitis with suspicion of Crohn’s disease. However, a diagnosis of primary EBV infection presenting as severe ulcerative oesophagitis and without systemic symptoms of infectious mononucleosis was made based on dynamic changes in EBV serology (shift from IgM to IgG positivity), EBV-specific immunohistochemical staining, and PCR analysis of biopsy specimens. This rare manifestation of primary EBV in an immunocompetent patient was treated symptomatically and resolved within a few weeks, and should be considered a differential diagnosis at otherwise unexplained ulcerative oesophagitis in younger individuals.

scholarly journals Acute Acalculous Cholecystitis Due to a Primary Epstein Barr Virus Infection in a Pediatric Patient

2021 ◽  
Vol 13 (1) ◽  
pp. 86-90
Author(s):  
Carlos Leganés Villanueva ◽  
Ilaria Goruppi ◽  
Nuria Brun Lozano ◽  
Federica Bianchi ◽  
María Quinteiro González ◽  
...  
Keyword(s):  
Infectious Mononucleosis ◽  
Epstein Barr Virus ◽  
Acalculous Cholecystitis ◽  
Acute Acalculous Cholecystitis ◽  
Epstein Barr Virus Infection ◽  
Barr Virus ◽  
Acute Complications ◽  
Epstein Barr ◽  
Barr Virus Infection ◽  
Human Viruses

Epstein–Barr virus (EBV) is estimated to infect more than 98% of adults worldwide and is one of the most common human viruses. Acute acalculous cholecystitis (AAC) of the gallbladder is an atypical complication of infectious mononucleosis caused by EBV. Conservative management has been described in the context of AAC caused by EBV. A surgical approach must be considered in the case of acute complications such as perforation or gallbladder gangrene. We present the case of a 10-year-old female patient with AAC due to infectious mononucleosis syndrome caused by primary EBV infection.

scholarly journals The specificity of heterophil antibodies in patients and healthy donors with no or minimal signs of infectious mononucleosis

Blood ◽  
1976 ◽  
Vol 47 (1) ◽  
pp. 91-98
Author(s):  
CA Horwitz ◽  
W Henle ◽  
G Henle ◽  
H Polesky ◽  
H Wexler ◽  
...  
Keyword(s):  
Infectious Mononucleosis ◽  
Epstein Barr Virus ◽  
Epstein Barr Virus Infection ◽  
Virus Infections ◽  
Barr Virus ◽  
Specimen Collection ◽  
Late Emergence ◽  
Nuclear Antigens ◽  
Epstein Barr ◽  
Barr Virus Infection

Over several years sera were collected from 14 heterophil-positive students or patients who did not fulfill minimal hematologic criteria for infectious mononucleosis (I.M.) The specificity of these heterophil reactions for I.M. was investigated by determining antibodies to Epstein-Barr virus-determined antigens, i.e., to viral capsid antigens (VCA), early antigens (EA), and EBV-associated nuclear antigens (EBNA). On the basis of detectable anti-EA and/or the early absence and late emergence of anti-EBNA, four of these 14 individuals showed evidence of a current or very recent primary Epstein-Barr virus infection. The other ten patients showed antibody patterns indicative of Epstein-Barr virus infections in the past, and no firm conclusions could be drawn with regard to the specificity of their heterophil reactions. It was assumed, however, that some represented atypical clinical forms of EBV infection and that timing of specimen collection was a factor in explaining the paucity of Downey cells. In three patients, the absorbed heterophil-positive reactions persisted with little change in titer for at least 22 mo and thus might represent false-positive tests.

scholarly journals Epidemiology of Epstein-Barr virus infection and infectious mononucleosis in the United Kingdom

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Ashvin Kuri ◽  
Benjamin Meir Jacobs ◽  
Nikki Vickaryous ◽  
Julia Pakpoor ◽  
Jaap Middeldorp ◽  
...  
Keyword(s):  
United Kingdom ◽  
Virus Infection ◽  
Infectious Mononucleosis ◽  
Epstein Barr Virus ◽  
Epstein Barr Virus Infection ◽  
Barr Virus ◽  
The United Kingdom ◽  
Epstein Barr ◽  
Barr Virus Infection

scholarly journals Human Natural Killer Cells Prevent Infectious Mononucleosis Features by Targeting Lytic Epstein-Barr Virus Infection

Cell Reports ◽  
2013 ◽  
Vol 5 (6) ◽  
pp. 1489-1498 ◽  
Author(s):  
Obinna Chijioke ◽  
Anne Müller ◽  
Regina Feederle ◽  
Mario Henrique M. Barros ◽  
Carsten Krieg ◽  
...  
Keyword(s):  
Natural Killer Cells ◽  
Virus Infection ◽  
Natural Killer ◽  
Infectious Mononucleosis ◽  
Epstein Barr Virus ◽  
Epstein Barr Virus Infection ◽  
Barr Virus ◽  
Human Natural Killer Cells ◽  
Epstein Barr ◽  
Barr Virus Infection

scholarly journals Epstein-Barr Virus Infection in an Elderly Nonimmunocompromised Adult Successfully Treated with Rituximab

2014 ◽  
Vol 2014 ◽  
pp. 1-4
Author(s):  
Jacob P. Smeltzer ◽  
Matthew T. Howard ◽  
Wilson I. Gonsalves ◽  
Thomas E. Witzig
Keyword(s):  
Epstein Barr Virus ◽  
The Elderly ◽  
Lymph Node Biopsy ◽  
Epstein Barr Virus Infection ◽  
Diagnostic Challenge ◽  
Barr Virus ◽  
Age Related ◽  
Epstein Barr ◽  
Barr Virus Infection ◽  
Systemic Symptoms

Epstein-Barr virus (EBV) is a ubiquitous virus that commonly affects children and adolescents. In addition to causing a viral illness, it is also associated with various malignancies in particular B cell lymphomas and lymphoproliferative disorders. Differentiating between the two processes can be a diagnostic challenge. Here, we present a case of an atypical EBV infection in an elderly patient with severe systemic symptoms, multiorgan involvement, lymphadenopathy, and negative EBV serology. Excisional lymph node biopsy demonstrated features of a lymphoproliferative process involving EBV. Despite supportive care, she experienced continued clinical deterioration and was successfully treated with rituximab. This case illustrates the diagnostic challenges of these cases particularly in the elderly who may have age related immunosenescence, the utility of EBV PCR testing, and the clinical efficacy of rituximab in clearing the infected cells.

scholarly journals Childcare attendance and risk of infectious mononucleosis: A population-based Danish cohort study

PLoS ONE ◽  
2021 ◽  
Vol 16 (12) ◽  
pp. e0261665
Author(s):  
Klaus Rostgaard ◽  
Lone Graff Stensballe ◽  
Signe Holst Søegaard ◽  
Mads Kamper-Jørgensen ◽  
Henrik Hjalgrim
Keyword(s):  
Virus Infection ◽  
Infectious Mononucleosis ◽  
Epstein Barr Virus ◽  
Cox Regression ◽  
Population Based ◽  
Epstein Barr Virus Infection ◽  
Barr Virus ◽  
Hazard Ratios ◽  
Epstein Barr ◽  
Barr Virus Infection

Background The risk of infectious mononucleosis (IM) is affected both by crowding and by sibship structure, i.e., number and signed age differential between an index child and a sibling. Siblings provide protection against IM by pre-empting delayed primary Epstein-Barr virus infection with its associated high risk of IM. The association between childcare attendance and risk of IM, on the other hand, has never been studied in a large, well-characterized cohort. Methods Danish children born in July 1992 through 2016 with a completely known simple childcare attendance history before age 1.5 years (n = 908,866) were followed up for a hospital contact with an IM diagnosis at ages 1.5–26 years. Hazard ratios (HRs) of IM for an additional year of exposure were obtained from stratified Cox regression analyses, stratified by sex and year of birth, with age as the underlying time scale, adjusted for sibship structure, and sociodemographic variables including parental ethnicity and maternal age. Results An additional year of exclusively attending a daycare home (max 5 children) yielded HR = 0.90 (95% confidence interval 0.81–1.00), and similarly, each year of exclusively attending a childcare institution (e.g., crèche) yielded HR = 0.94 (0.84–1.06). Conclusions Forwarding enrollment in childcare by a year lowers the risk of IM later in life much less than having an additional sibling of comparable age and has no practical public health implications. We find our results suggestive of a random threshold for successful Epstein-Barr virus infection that is more easily reached by a sibling than the collective of playmates in daycare homes or childcare institutions.

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