scholarly journals Epstein-Barr Virus Infection in an Elderly Nonimmunocompromised Adult Successfully Treated with Rituximab

2014 ◽  
Vol 2014 ◽  
pp. 1-4
Author(s):  
Jacob P. Smeltzer ◽  
Matthew T. Howard ◽  
Wilson I. Gonsalves ◽  
Thomas E. Witzig
Keyword(s):  
Epstein Barr Virus ◽  
The Elderly ◽  
Lymph Node Biopsy ◽  
Epstein Barr Virus Infection ◽  
Diagnostic Challenge ◽  
Barr Virus ◽  
Age Related ◽  
Epstein Barr ◽  
Barr Virus Infection ◽  
Systemic Symptoms

Epstein-Barr virus (EBV) is a ubiquitous virus that commonly affects children and adolescents. In addition to causing a viral illness, it is also associated with various malignancies in particular B cell lymphomas and lymphoproliferative disorders. Differentiating between the two processes can be a diagnostic challenge. Here, we present a case of an atypical EBV infection in an elderly patient with severe systemic symptoms, multiorgan involvement, lymphadenopathy, and negative EBV serology. Excisional lymph node biopsy demonstrated features of a lymphoproliferative process involving EBV. Despite supportive care, she experienced continued clinical deterioration and was successfully treated with rituximab. This case illustrates the diagnostic challenges of these cases particularly in the elderly who may have age related immunosenescence, the utility of EBV PCR testing, and the clinical efficacy of rituximab in clearing the infected cells.

Case Report: Severe cholestatic jaundice induced by Epstein-Barr virus infection in the elderly

1998 ◽  
Vol 13 (8) ◽  
pp. 821-824 ◽  
Author(s):  
YEOUDA EDOUTE ◽  
YAACOV BARUCH ◽  
JESSE LACHTER ◽  
EIAL FURMAN ◽  
LUDISSIA BASSAN ◽  
...  
Keyword(s):  
Case Report ◽  
Virus Infection ◽  
Epstein Barr Virus ◽  
The Elderly ◽  
Cholestatic Jaundice ◽  
Epstein Barr Virus Infection ◽  
Barr Virus ◽  
Epstein Barr ◽  
Barr Virus Infection

scholarly journals Unusual Presentation of Gianotti-Crosti Syndrome due to Epstein-Barr Virus Infection

2016 ◽  
Vol 2016 ◽  
pp. 1-2
Author(s):  
Hind Saif Al Dhaheri ◽  
Amani Al Kaabi ◽  
Yasmin Kara Hamo ◽  
Aysha Al Kaabi ◽  
Salwa Al Kaabi ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Virus Infection ◽  
Epstein Barr Virus ◽  
Epstein Barr Virus Infection ◽  
Barr Virus ◽  
Ebv Infection ◽  
B Virus ◽  
Epstein Barr ◽  
Barr Virus Infection ◽  
Systemic Symptoms

Gianotti-Crosti syndrome (GCS) is viral exanthema of childhood. It typically presents with a symmetric erythematous papular and papulovesicular eruption. It has been classically associated with hepatitis B virus, as well as rarely with Epstein-Barr virus (EBV). We report a case of GCS related to EBV infection without the classical systemic symptoms in a five-year-old male patient.

Chronic Active Epstein-Barr Virus Infection in a Patient with Enteritis, Myositis, and Pericardial Effusion: A Case Report

2020 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Jin-Xian Huang ◽  
Xiao-Yan Huang ◽  
Li-Jun Zhang ◽  
Ya-Qin Wang
Keyword(s):  
Pericardial Effusion ◽  
Virus Infection ◽  
Early Diagnosis ◽  
Epstein Barr Virus ◽  
Disease Onset ◽  
The Elderly ◽  
Epstein Barr Virus Infection ◽  
Barr Virus ◽  
Epstein Barr ◽  
Barr Virus Infection

Introduction: Chronic active Epstein-Barr virus infection (CAEBV) is a rare, life-threatening disease entity involving multiple organs and systems. The disease could be presented in a single organ with atypical symptoms, be misdiagnosed at the early phase, and resolved without aggressive treatment. Previous studies reported favorable outcomes with early diagnosis and treatment, while in other cases, disease progression and presenting in other organs could result in a very poor outcome. Clinicians from any department should be aware of the CAEBV entity when an unresolved systemic inflammation presents. Case Presentation: A 61-year-old female presented to the cardiology department due to edema and fatigue with the progression of symptoms, including fever, muscle weakness, and shortness of breath. MR images showed muscular edema, and ultrasound analysis revealed massive pericardial effusion. Results of laboratory tests indicated hematological involvement, liver damage, and positivity for EBV DNA, and EBER in muscle and intestine by staining. She was first misdiagnosed with ulcerative colitis, but the disease evolved to the muscles and cardiovascular system later on. Altogether, the CAEBV infection with enteritis, myositis, and pericardial effusion was confirmed in the case. Although diagnosed, the treatment of the elderly population remains rather challenging in severe cases. The patient died after disease onset for less than three years. Conclusions: Elderly patients with CAEBV infection tend to have a poor prognosis. Early diagnosis would facilitate early treatment and the utilization of available options, which might reduce the disease mortality rate eventually. Individualized therapy and promising approaches should be further developed for CAEBV infection.

scholarly journals Severe ulcerative oesophagitis caused by primary Epstein-Barr virus infection in an immunocompetent individual

2021 ◽  
Vol 8 (1) ◽  
pp. e000586
Author(s):  
Ruben Due Lorentsen ◽  
Louise Laurberg Klarskov ◽  
Casper Steenholdt
Keyword(s):  
Infectious Mononucleosis ◽  
Epstein Barr Virus ◽  
Epigastric Pain ◽  
Immunocompetent Patient ◽  
Pcr Analysis ◽  
Epstein Barr Virus Infection ◽  
Barr Virus ◽  
Epstein Barr ◽  
Barr Virus Infection ◽  
Systemic Symptoms

Epstein-Barr virus (EBV) infects the vast majority of the human population. The primary infection in immunocompetent individuals is typically asymptomatic or presenting as infectious mononucleosis. Here, an 18-year-old man without medical history was admitted with mild non-specific symptoms of infection presenting primarily with severe dysphagia and epigastric pain. Gastroscopy revealed severe, extensive, ulcerative oesophagitis with suspicion of Crohn’s disease. However, a diagnosis of primary EBV infection presenting as severe ulcerative oesophagitis and without systemic symptoms of infectious mononucleosis was made based on dynamic changes in EBV serology (shift from IgM to IgG positivity), EBV-specific immunohistochemical staining, and PCR analysis of biopsy specimens. This rare manifestation of primary EBV in an immunocompetent patient was treated symptomatically and resolved within a few weeks, and should be considered a differential diagnosis at otherwise unexplained ulcerative oesophagitis in younger individuals.

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