Detection of intracranial hypertension in children using optical coherence tomography: a systematic review

ObjectivesTo evaluate the diagnostic capability of optical coherence tomography (OCT) in children aged under 18 years old with intracranial hypertension (IH).DesignSystematic review.MethodsWe conducted a systematic review using the following platforms to search the keywords ‘optical coherence tomography’ and ‘intracranial hypertension’ from inception to 2 April 2020: Cochrane Central Register of Controlled Trials, EMBASE, MEDLINE, PubMed and Web of Science, without language restrictions. Our search returned 2729 records, screened by two independent screeners. Studies were graded according to the Oxford Centre for Evidence-Based Medicine and National Institutes of Health Quality Assessment Tool for observational studies.ResultsTwenty-one studies were included. Conditions included craniosynostosis (n=354 patients), idiopathic IH (IIH; n=102), space-occupying lesion (SOL; n=42) and other pathology (n=29). OCT measures included optic nerve parameters, rim parameters (notably retinal nerve fibre layer thickness) and retinal parameters. Levels of evidence included 2b (n=13 studies), 3b (n=4) and 4 (n=4). Quality of 10 studies was fair and 11 poor. There was inconsistency in OCT parameters and reference measures studied, although OCT did demonstrate good diagnostic capability for IH in craniosynostosis, IIH and SOL.ConclusionsThis systematic review identified various studies involving OCT to assist diagnosis and management of IH in children with craniosynostosis, IIH, SOL and other pathology, in conjunction with established clinical measures of intracranial pressure. However, no level 1 evidence was identified. Validating prospective studies are, therefore, required to determine optimal OCT parameters in this role and to develop formal clinical guidelines.PROSPERO registration numberCRD42019154254.

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The range of peripapillary retinal nerve fibre layer and optic disc parameters in children aged up to but not including 18 years of age, as measured by optical coherence tomography: protocol for a systematic review

Systematic Reviews ◽

10.1186/s13643-016-0247-z ◽

2016 ◽

Vol 5 (1) ◽

Cited By ~ 1

Author(s):

Alexandra L. Creavin ◽

Cathy Williams ◽

Kate Tilling ◽

Nicholas Timpson ◽

Julian P. T. Higgins

Keyword(s):

Systematic Review ◽

Optical Coherence Tomography ◽

Optic Disc ◽

Nerve Fibre ◽

Retinal Nerve Fibre Layer ◽

Optical Coherence ◽

Fibre Layer ◽

Nerve Fibre Layer

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Segmentation error in spectral domain optical coherence tomography measures of the retinal nerve fibre layer thickness in idiopathic intracranial hypertension

BMC Ophthalmology ◽

10.1186/s12886-017-0652-7 ◽

2017 ◽

Vol 17 (1) ◽

Cited By ~ 8

Author(s):

Anuriti Aojula ◽

Susan P Mollan ◽

John Horsburgh ◽

Andreas Yiangou ◽

Kiera A Markey ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Intracranial Hypertension ◽

Layer Thickness ◽

Nerve Fibre ◽

Idiopathic Intracranial Hypertension ◽

Retinal Nerve Fibre Layer ◽

Spectral Domain ◽

Optical Coherence ◽

Segmentation Error ◽

Nerve Fibre Layer

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Retinal nerve fibre layer thickness measurements in childhood glaucoma: the role of scanning laser polarimetry and optical coherence tomography

Graefe s Archive for Clinical and Experimental Ophthalmology ◽

10.1007/s00417-021-05276-z ◽

2021 ◽

Author(s):

Mael Lever ◽

Christian Halfwassen ◽

Jan Darius Unterlauft ◽

Nikolaos E. Bechrakis ◽

Anke Manthey ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Nerve Fibre ◽

Retinal Nerve Fibre Layer ◽

Scanning Laser ◽

Optical Coherence ◽

Scanning Laser Polarimetry ◽

Laser Polarimetry ◽

Nerve Fibre Layer ◽

Thickness Measurements ◽

Inferior Quadrant

Abstract Purpose A central diagnostic tool in adult glaucoma is the peripapillary retinal nerve fibre layer (pRNFL) thickness. It can be assessed by scanning laser polarimetry (SLP) or optical coherence tomography (OCT). However, studies investigating the relevance of pRNFL measurements in children are rare. This study aims to compare the glaucoma diagnosing ability of SLP and OCT pRNFL thickness measurements in a paediatric population. Methods This retrospective study included 105 children (glaucoma: 22 (21.0%); healthy glaucoma suspects: 83 (79.0%)) aged 4–18 years, examined with SLP (GDxPro/ECC, Carl Zeiss Meditec) and spectral-domain OCT (SPECTRALIS®, Heidelberg Engineering). The thickness of pRNFL sectors was compared between diseased and healthy participants. Areas under the receiver-operating characteristic curves (AUC) and logistic regression results were used to compare the glaucoma discriminative capacity between SLP and OCT measurements. Results Using OCT, pRNFL thickness was decreased in the superior, nasal, and inferior quadrants of glaucoma patients compared to healthy controls (P < 0.001, each). With SLP, such a difference was only observed in the inferior quadrant (P = 0.011). A correlation between glaucoma diagnosis and OCT-measured pRNFL thickness was found in all quadrants (P < 0.001) other than the temporal. With SLP, a correlation was found for the total average thickness (P = 0.037) and inferior quadrant (P = 0.0019). Finally, the AUCs of OCT measurements were markedly higher than those of SLP (e.g., inferior quadrant: OCT 0.83, SLP 0.68). Conclusion pRNFL thickness measurements using both OCT and SLP, correlate notably with the presence of glaucoma. In general, the diagnostic performance of pRNFL thickness measurements seems higher for OCT than for SLP. Thus, pRNFL thickness measurements could provide important information, complementing conventional clinical and functional parameters in the diagnostic process of paediatric glaucoma.

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