Inactivated influenza vaccination in first trimester does not appear to increase risk of birth defects

Objective: Seasonal inactivated influenza vaccine (IIV) is recommended during pregnancy to protect both mothers and infants from severe infection. Most studies have evaluated the risk of major structural birth defects in infants associated with prenatal administration of pandemic IIV. Our aim was to estimate the risk in infants associated with prenatal administration of seasonal IIV. Design: Retrospective population-based observational study Setting: Western Australia Population or sample: All pregnant women with a singleton birth from 2012-2016 Methods: 125,866 singleton births were linked to the state’s registers for congenital anomalies and a state prenatal vaccination database. We estimated prevalence ratios (PR) of any major structural birth defect and defects by organ system. Inverse probability treatment weighting factored for baseline probability for vaccination. Bonferroni correction was applied to account for multiple comparisons. Main outcome measures: Prevalence ratios by vaccination and major structural birth defects categories or specific birth defects diagnosed within one month of birth or within six years of life. Results: 3.9% of births had a major structural birth defect. IIV exposure during the first trimester was not associated with diagnosis of any major structural birth defect diagnosed within one month of birth (PR 0.98, 95% CI: 0.77, 1.28) or within six years of life (PR 1.02, 95% CI: 0.78, 1.35). We identified no increased risk in specific birth defects associated with IIV. Conclusions: Results suggest there is no association between maternal influenza vaccination and risk of major structural birth defects. These results support the safety of IIV administration during pregnancy.

Download Full-text

First Trimester Influenza Vaccination and Risks for Major Structural Birth Defects in Offspring

The Journal of Pediatrics ◽

10.1016/j.jpeds.2017.04.039 ◽

2017 ◽

Vol 187 ◽

pp. 234-239.e4 ◽

Cited By ~ 24

Author(s):

Elyse Olshen Kharbanda ◽

Gabriela Vazquez-Benitez ◽

Paul A. Romitti ◽

Allison L. Naleway ◽

T. Craig Cheetham ◽

...

Keyword(s):

Influenza Vaccination ◽

Birth Defects ◽

First Trimester

Download Full-text

New Study Finds Increased Risk of Birth Defects Related to First Trimester Use of ACE Inhibitors

PsycEXTRA Dataset ◽

10.1037/e555082006-001 ◽

2006 ◽

Keyword(s):

Birth Defects ◽

Ace Inhibitors ◽

First Trimester ◽

Increased Risk

Download Full-text

Influenza Vaccination in the First Trimester of Pregnancy and Risk of Autism Spectrum Disorder—Reply

JAMA Pediatrics ◽

10.1001/jamapediatrics.2017.0737 ◽

2017 ◽

Vol 171 (6) ◽

pp. 601 ◽

Cited By ~ 6

Author(s):

Ousseny Zerbo ◽

Nicola P. Klein ◽

Lisa A. Croen

Keyword(s):

Autism Spectrum Disorder ◽

Influenza Vaccination ◽

First Trimester ◽

Autism Spectrum ◽

Spectrum Disorder ◽

First Trimester Of Pregnancy

Download Full-text

Maternal occupational exposure to solvents and gastroschisis in offspring - National Birth Defects Prevention Study 1997–2011

Occupational and Environmental Medicine ◽

10.1136/oemed-2019-106147 ◽

2020 ◽

Vol 77 (3) ◽

pp. 172-178 ◽

Cited By ~ 1

Author(s):

Nynke Spinder ◽

Lynn M Almli ◽

Tania A Desrosiers ◽

Kathryn E Arnold ◽

Jorieke E H Bergman ◽

...

Keyword(s):

Occupational Exposure ◽

Birth Defects ◽

Maternal Age ◽

Large Population ◽

First Trimester ◽

Population Based ◽

Cumulative Exposure ◽

Surveillance Systems ◽

Prevention Study ◽

Solvent Exposure

ObjectivesThe aim of this study was to assess the association between maternal occupational exposure to solvents and gastroschisis in offspring.MethodsWe used data from the National Birth Defects Prevention Study, a large population-based case-control study of major birth defects conducted in 10 US states from 1997 to 2011. Infants with gastroschisis were ascertained by active birth defects surveillance systems. Control infants without major birth defects were selected from vital records or birth hospital records. Self-reported maternal occupational histories were collected by telephone interview. Industrial hygienists reviewed this information to estimate exposure to aromatic, chlorinated and petroleum-based solvents from 1 month before conception through the first trimester of pregnancy. Cumulative exposure to solvents was estimated for the same period accounting for estimated exposure intensity and frequency, job duration and hours worked per week. ORs and 95% CIs were estimated to assess the association between exposure to any solvents or solvent classes, and gastroschisis risk.ResultsAmong 879 cases and 7817 controls, the overall prevalence of periconceptional solvent exposure was 7.3% and 7.4%, respectively. Exposure to any solvent versus no exposure to solvents was not associated with gastroschisis after adjusting for maternal age (OR 1.00, 95% CI 0.75 to 1.32), nor was an association noted for solvent classes. There was no exposure-response relationship between estimated cumulative solvent exposure and gastroschisis after adjusting for maternal age.ConclusionOur study found no association between maternal occupational solvent exposure and gastroschisis in offspring. Further research is needed to understand risk factors for gastroschisis.

Download Full-text

Congenital Bands with Intestinal Malrotation after Propylthiouracil Exposure in Early Pregnancy

Case Reports in Endocrinology ◽

10.1155/2015/789762 ◽

2015 ◽

Vol 2015 ◽

pp. 1-4 ◽

Cited By ~ 2

Author(s):

Alexander A. Leung ◽

Jennifer Yamamoto ◽

Paola Luca ◽

Paul Beaudry ◽

Julie McKeen

Keyword(s):

Birth Defects ◽

Early Pregnancy ◽

First Trimester ◽

Careful Consideration ◽

Intestinal Malrotation ◽

Graves Disease ◽

Increased Risk ◽

Acute Small Bowel Obstruction ◽

Trimester Exposure ◽

Duration Of Pregnancy

Exposure to propylthiouracil in early pregnancy may be associated with an increased risk of birth defects. But the spectrum of associated congenital anomalies is not yet well defined. While preliminary reports suggest that most cases of propylthiouracil-associated birth defects are restricted to the preauricular and urinary systems, careful consideration should be given to other possible manifestations of teratogenicity. We propose that congenital bands may potentially represent a rare yet serious complication of propylthiouracil exposure in early pregnancy, possibly arising from an early mesenteric developmental anomaly. We report a case of a 17-day-old girl that presented with acute small bowel obstruction associated with intestinal malrotation arising from several anomalous congenital bands. Her mother was treated for Graves’ disease during pregnancy with first trimester exposure to propylthiouracil but remained clinically and biochemically euthyroid at conception and throughout the duration of pregnancy. This case suggests that the use of propylthiouracil in early pregnancy may be associated with congenital bands and intestinal malrotation. More reports are needed to further support this association.

Download Full-text