scholarly journals Differences in the mode of the extension of gastric cancer classified by histological type: new histological classification of gastric carcinoma.

Gut ◽  
1992 ◽  
Vol 33 (5) ◽  
pp. 606-612 ◽  
Author(s):  
N Goseki ◽  
T Takizawa ◽  
M Koike
Keyword(s):  
Gastric Cancer ◽  
Gastric Carcinoma ◽  
Histological Type ◽  
Histological Classification

scholarly journals Molecular genetic changes in gastric carcinoma

2021 ◽  
Vol 6 ◽  
pp. 30-46
Author(s):  
Juhi Singh ◽  
Puneet Kumar ◽  
Khushi Verma ◽  
Satyender Kumar Tiwary ◽  
Gopeshwar Narayan ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Gastric Carcinoma ◽  
Wide Spectrum ◽  
Molecular Genetic ◽  
Survival Rates ◽  
High Throughput Analysis ◽  
Genetic Changes ◽  
Genetic Level ◽  
New Biomarkers

Gastric cancer remains highly prevalent and accounts for a notable proportion of global cancer mortality and this is associated with poor survival rates. Understanding the molecular genetic changes of gastric carcinoma may offer an insight into its pathogenesis helps in identifying new biomarkers, aid prognostication, and novel treatment targets. Over a past few decades, advances in technology and high throughput analysis have improved understanding of the molecular genetic aspects of gastric cancer. In this article, hierarchy of the changes at genetic and molecular level including several aspects which are heterogenous and represents a wide spectrum such as tumor suppressor genes, oncogenes, cellcycle regulators, apoptosis, cell-adhesion molecules, loss of heterozygosity, microsatellite instability, and epigenetic changes. The classification of gastric carcinoma at molecular and genetic level as well as hereditary gastric carcinoma is elaborated. The molecular genetic aspects regarding pathogenesis, changes and aberrations of all genes and pathways which are involved in gastric cancer are addressed in this review.

scholarly journals Clinicopathological analysis for recurrence of stage Ib gastric cancer (according to the second English edition of the Japanese classification of gastric carcinoma)

2011 ◽  
Vol 14 (4) ◽  
pp. 372-377 ◽  
Author(s):  
Takashi Yokoyama ◽  
Kiyoshi Kamada ◽  
Yoshikazu Tsurui ◽  
Hisanori Kashizuka ◽  
Eiji Okano ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Gastric Carcinoma ◽  
English Edition ◽  
Stage Ib ◽  
Japanese Classification ◽  
Clinicopathological Analysis

The decision criterion of histological mixed type in “T1/T2” gastric carcinoma-comparison between TNM classification and Japanese classification of gastric cancer

2011 ◽  
Vol 105 (8) ◽  
pp. 800-804 ◽  
Author(s):  
Hiroki Shimizu ◽  
Daisuke Ichikawa ◽  
Shuhei Komatsu ◽  
Kazuma Okamoto ◽  
Atsushi Shiozaki ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Gastric Carcinoma ◽  
Mixed Type ◽  
Tnm Classification ◽  
Decision Criterion ◽  
Japanese Classification

scholarly journals Clinicopathological Features Associated with Lymph Node Metastasis in Early Gastric Cancer: Analysis of a Single-Institution Experience in China

2009 ◽  
Vol 23 (5) ◽  
pp. 353-356 ◽  
Author(s):  
Lizong Shen ◽  
Yiming Huang ◽  
Maocai Sun ◽  
Hao Xu ◽  
Wei Wei ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Early Gastric Cancer ◽  
Gastric Carcinoma ◽  
Tumour Size ◽  
Lymphatic Invasion ◽  
Histological Classification ◽  
Node Metastasis ◽  
Macroscopic Type

BACKGROUND: An accurate assessment of potential lymph node metastasis is an important issue for the appropriate treatment of early gastric cancer. Minimizing the number of invasive procedures used in cancer therapy is critical for improving the patient’s quality of life.OBJECTIVE: To evaluate the clinicopathological features associated with lymph node metastasis of early gastric cancer in patients from a single institution in China.METHODS: A retrospective review of data from 410 patients surgically treated for early gastric cancer at the First Affiliated Hospital (Nanjing, China) between 1998 and 2007, was conducted. The clinicopathological variables associated with lymph node metastasis were evaluated.RESULTS: Lymph node metastasis was observed in 12.20% of patients. The macroscopic type, tumour size, location in the stomach, depth of gastric carcinoma infiltration, and presence of vascular or lymphatic invasion showed a positive correlation with the incidence of lymph node metastasis by univariate analysis. Multivariate analyses revealed histological classification, macroscopic type, tumour size, depth of gastric carcinoma infiltration, and the presence of vascular or lymphatic invasion to be significantly and independently related to lymph node metastasis. The depth of gastric carcinoma infiltration was the strongest predictive factor for lymph node metastasis. For intramucosal cancer, tumour size was the unique risk factor for lymph node metastasis. For submucosal cancer, histological classification and tumour size were independent risk factors for lymph node metastasis.CONCLUSIONS: Histological classification, macroscopic type, tumour size, depth of gastric carcinoma infiltration, and the presence of vascular or lymphatic invasion are independent risk factors for lymph node metastasis in patients with early gastric cancer in China. Minimal invasive treatment, such as endoscopic mucosal resection, may be possible for highly selected cancers.

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