scholarly journals PWE-027 HALO radiofrequency ablation for squamous high grade dysplasia and early squamous cell carcinoma: outcomes form the UK HALO radiofrequency ablation registry

Gut ◽  
2012 ◽  
Vol 61 (Suppl 2) ◽  
pp. A307.3-A308
Author(s):  
R J Haidry ◽  
J Dunn ◽  
M Banks ◽  
A Gupta ◽  
M A Butt ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Radiofrequency Ablation ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
High Grade Dysplasia ◽  
High Grade ◽  
Early Squamous Cell Carcinoma ◽  
The Uk

scholarly journals Influence of Tea Consumption on the Development of Second Esophageal Neoplasm in Patients with Head and Neck Cancer

Cancers ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 387 ◽  
Author(s):  
Yao-Kuang Wang ◽  
Wei-Chung Chen ◽  
Ying-Ho Lai ◽  
Yi-Hsun Chen ◽  
Ming-Tsang Wu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Esophageal Neoplasm ◽  
In Vitro Studies ◽  
High Grade Dysplasia ◽  
High Grade ◽  
Tea Consumption

Alcohol is an important risk factor for the development of second esophageal squamous-cell carcinoma (ESCC) in head and neck squamous-cell carcinoma (HNSCC) patients. However, the influence of tea consumption is uncertain. We prospectively performed endoscopic screening in incident HNSCC patients to identify synchronous esophageal neoplasm. In total, 987 patients enrolled between October 2008 and December 2017 and were analyzed. In vitro studies were conducted to investigate the effect of epigallocatechin gallate (EGCG) on the betel alkaloid, arecoline-stimulated carcinogenesis in two ESCC cell lines. There were 151 patients (15.3%) diagnosed to have synchronous esophageal neoplasm, including 88 low-grade dysplasia, 30 high-grade dysplasia and 33 squamous-cell carcinoma (SCC). Tea consumption was associated with a significantly lower risk of having esophageal high-grade dysplasia or SCC in HNSCC patients, especially those who were betel nut chewers, alcohol drinkers or cigarette smokers (all adjusted odds ratio were 0.5; p-values: 0.045, 0.045 and 0.049 respectively). In vitro studies indicated that EGCG suppressed arecoline-induced ESCC cell proliferation and colony formation through the inhibition of the Akt and ERK1/2 pathway in a reactive oxygen species-independent manner. In conclusion, tea consumption may protect against the development of second esophageal neoplasms among HNSCC patients, especially those who regularly consume betel nuts, alcohol and cigarettes.

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