Risk of acute arterial events associated with treatment of inflammatory bowel diseases: a nationwide Danish cohort study

Gut ◽  
2022 ◽  
pp. gutjnl-2021-326462
Author(s):  
Daniel Ward ◽  
Mikael Andersson ◽  
Nynne Nyboe Andersen ◽  
Kristine Højgaard Allin ◽  
Laurent Beaugerie ◽  
...  
Keyword(s):  
Cohort Study ◽  
Inflammatory Bowel Diseases ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Danish Cohort

Su1850 RISK OF INCIDENT PARADOXICAL IMMUNE-MEDIATED INFLAMMATORY DISEASES IN PATIENTS WITH INFLAMMATORY BOWEL DISEASES TREATED WITH ANTI-TNF THERAPIES: A NATIONWIDE DANISH COHORT STUDY

2020 ◽  
Vol 158 (6) ◽  
pp. S-674
Author(s):  
Daniel Ward ◽  
Sanne Gørtz ◽  
Nynne Nyboe Andersen ◽  
Julien Kirchgesner ◽  
Tine Jess
Keyword(s):  
Cohort Study ◽  
Inflammatory Bowel Diseases ◽  
Inflammatory Diseases ◽  
Immune Mediated ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Danish Cohort

Prevalence and Implications of Frailty in Older Adults with Incident Inflammatory Bowel Diseases: a Nationwide Cohort Study

2022 ◽  
Author(s):  
Bharati Kochar ◽  
Juulia Jylhävä ◽  
Jonas Söderling ◽  
Christine S. Ritchie ◽  
Jonas F. Ludvigsson ◽  
...  
Keyword(s):  
Older Adults ◽  
Cohort Study ◽  
Inflammatory Bowel Diseases ◽  
Bowel Diseases ◽  
Inflammatory Bowel

Mo1836 IMPACT OF THERAPEUTIC STRATEGIES ON INTESTINAL RESECTION RATE IN PAEDIATRIC INFLAMMATORY BOWEL DISEASES: A POPULATION-BASED COHORT STUDY OVER A 24-YEAR PERIOD (1988-2011)

2020 ◽  
Vol 158 (6) ◽  
pp. S-942-S-943
Author(s):  
Delphine Ley ◽  
Ariane Leroyer ◽  
Claire Dupont ◽  
Helene Sarter ◽  
Valérie Bertrand ◽  
...  
Keyword(s):  
Cohort Study ◽  
Inflammatory Bowel Diseases ◽  
Intestinal Resection ◽  
Population Based ◽  
Therapeutic Strategies ◽  
Resection Rate ◽  
Bowel Diseases ◽  
Inflammatory Bowel

scholarly journals Risk of intestinal and extra-intestinal cancers in patients with inflammatory bowel diseases: A population-based cohort study in northeastern Italy

PLoS ONE ◽  
2020 ◽  
Vol 15 (6) ◽  
pp. e0235142
Author(s):  
Martina Taborelli ◽  
Michele Sozzi ◽  
Stefania Del Zotto ◽  
Federica Toffolutti ◽  
Marcella Montico ◽  
...  
Keyword(s):  
Cohort Study ◽  
Inflammatory Bowel Diseases ◽  
Population Based ◽  
Bowel Diseases ◽  
Northeastern Italy ◽  
Inflammatory Bowel

Trends in the use of biologicals and their treatment outcomes among patients with inflammatory bowel diseases – a Danish nationwide cohort study

2021 ◽  
Author(s):  
Mirabella Zhao ◽  
Morten Sall Jensen ◽  
Torben Knudsen ◽  
Jens Kelsen ◽  
Mehmet Coskun ◽  
...  
Keyword(s):  
Cohort Study ◽  
Treatment Outcomes ◽  
Inflammatory Bowel Diseases ◽  
Bowel Diseases ◽  
Inflammatory Bowel

scholarly journals P795 Risk of incident paradoxical immune-mediated inflammatory diseases in patients with inflammatory bowel diseases treated with anti-TNF therapies: a nationwide Danish cohort study

2020 ◽  
Vol 14 (Supplement_1) ◽  
pp. S625-S625
Author(s):  
D WARD ◽  
S Gørtz ◽  
N Nyboe Andersen ◽  
J Kirchgesner ◽  
T Jess
Keyword(s):  
Rheumatoid Arthritis ◽  
Cohort Study ◽  
Inflammatory Bowel Diseases ◽  
Hidradenitis Suppurativa ◽  
Inflammatory Diseases ◽  
Hazard Ratios ◽  
Immune Mediated ◽  
Bowel Diseases ◽  
Lag Period ◽  
Inflammatory Bowel

Abstract Background Tumour necrosis factor (TNF) has a central role in the pathophysiology of immune-mediated inflammatory diseases (IMIDs) including rheumatoid arthritis, psoriasis, hidradenitis suppurativa, and inflammatory bowel diseases (IBD). However, there have been case reports of patients receiving an anti-TNF therapy for one IMID subsequently developing a second IMID. We conducted a nationwide cohort study investigating the risk of incident IMID following anti-TNF exposure in patients with IBD in Denmark. Methods We followed patients with IBD from 1 January 2005 or date of IBD diagnosis (whichever occurred last) to an outcome event including incident diagnosis of hidradenitis suppurativa, arthropathic psoriasis, other forms of psoriasis, or rheumatoid arthritis; or emigration, death or 31 December 2018 (whichever occurred first). Patients were defined as exposed after a 3-month lag period from first anti-TNF infusion throughout follow-up, analogous to an intention-to-treat design. The lag period was censored from analyses to avoid including incipient IMIDs, unlikely to be caused by newly initiated anti-TNF treatment. We excluded patients initiating anti-TNF or with an outcome diagnosis before either 1 January 2005 or IBD diagnosis. We used Cox regression models with age as the underlying timescale, and sex, type of IBD (Crohn’s disease or ulcerative colitis), and calendar period of IBD diagnosis (in 5 year groups) as strata to estimate hazard ratios for each outcome, comparing anti-TNF users and non-users. Results Incidence rates (and 95% confidence intervals [CI]) as events per 100 000 person-years among anti-TNF users and non-users were, respectively, 138 (109–173) and 25.6 (22.0–29.7) for hidradenitis suppurativa, 26.3 (15.6–44.4) and 7.81 (5.95–10.2) for arthropathic psoriasis, 1177 (1085–1277) and 204 (121–189) for other forms of psoriasis, and 152 (121–189) and 95.6 (88.5–103) for rheumatoid arthritis. Hazard ratios (and 95% C.I.) were increased for hidradenitis suppurativa 2.91 (2.15–3.94), arthropathic psoriasis 2.62 (1.40–4.93), other forms of psoriasis 4.76 (4.27–5.31), and rheumatoid arthritis 2.35 (1.83–3.01). Conclusion The results indicate that patients with IBD receiving anti-TNF have an increased risk of IMIDs. An almost 5-fold increase in the risk of psoriasis is consistent with previous reports of psoriasiform skin lesions related to anti-TNF use. However, as more severe IBD is likely to be associated with both initiating anti-TNF and the incidence of other inflammatory diseases, the results are subject to confounding by indication. Thus, these results should be considered preliminary, and we plan to further address confounding by using propensity score methods.

Sa1824 A PROSPECTIVE COHORT STUDY OF ADHERENCE TO HEALTHY LIFESTYLE AND MORTALITY IN OLDER PATIENTS WITH INFLAMMATORY BOWEL DISEASES

2020 ◽  
Vol 158 (6) ◽  
pp. S-440-S-441
Author(s):  
Chun-Han Lo ◽  
Hamed Khalili ◽  
Mingyang Song ◽  
Paul Lochhead ◽  
Kristin E. Burke ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Inflammatory Bowel Diseases ◽  
Prospective Cohort ◽  
Older Patients ◽  
Healthy Lifestyle ◽  
Bowel Diseases ◽  
Inflammatory Bowel
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