Carcinosarcoma-like mural nodule in intestinal-type mucinous ovarian of borderline malignancy: a case report

Epithelial ovarian tumors of borderline malignancy are tumors with histologic features and biologic behavior between benign and frankly malignant epithelial ovarian neoplasms. To date, we cannot accurately predict the patients who are prone to an aggressive course of disease. Here, we present a 35-year-old patient with carcinosarcoma-like mural nodule in intestinal-type mucinous ovarian tumor of borderline malignancy. Foci of intraepithelial carcinoma (about 10%) without stromal invasion are also noted. Total hysterectomy, bilateral salpingo-oophorectomy, appendectomy, and omentectomy were performed, and the frozen pathology during operation showed mucinous tumor of borderline malignancy of left ovary on April 18, 2002. The patient was followed at our outpatient department for 19 months after operation and was free of the disease without any adjuvant chemotherapy. It is difficult to determine whether intestinal-type borderline mucinous tumors with intraepithelial carcinoma are associated with a worse prognosis compared with those with epithelial atypia alone due to disparate results in the published literature. In contrast, most patients with mural nodules of anaplastic carcinoma have had a malignant, often rapid, course. However, too few cases of carcinosarcoma-like mural nodule in mucinous tumor have been published to warrant a conclusion regarding their prognosis.

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Benign Mucinous Tumor of Ovary with a Sarcoma-Like Mural Nodule: A Case Report

Case Reports in Oncological Medicine ◽

10.1155/2012/213765 ◽

2012 ◽

Vol 2012 ◽

pp. 1-2

Author(s):

Sailabala Garikaparthi ◽

Renuka Inuganti Venkata ◽

Krishna Bharathi Yarlagadda ◽

Annapurna Parvatala

Keyword(s):

Case Report ◽

Ovarian Tumor ◽

Anaplastic Carcinoma ◽

Mural Nodule ◽

Mucinous Tumor ◽

Middle Aged ◽

Worse Prognosis ◽

Mural Nodules

Sarcoma-like mural nodules occur predominantly in middle-aged women. Distinction of these lesions from true sarcomatous nodules and foci of anaplastic carcinoma is important because of the worse prognosis of these tumors in comparison with the favorable behavior of sarcoma-like mural nodules. In this report we describe the case of a 35-year-old woman with a mucinous ovarian tumor having a mural nodule in the wall.

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Carcinosarcoma-like mural nodule in intestinal-type mucinous ovarian of borderline malignancy: a case report

International Journal of Gynecological Cancer ◽

10.1111/j.1525-1438.2005.15323.x ◽

2005 ◽

Vol 15 (3) ◽

pp. 549-553 ◽

Cited By ~ 9

Author(s):

W.-C. Chang ◽

B.-C. Sheu ◽

M.-C. Lin ◽

S.-N. Chow ◽

S.-C. Huang

Keyword(s):

Case Report ◽

Intestinal Type ◽

Mural Nodule ◽

Borderline Malignancy

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Anaplastic carcinoma showing rhabdoid features combined with ovarian mucinous borderline cystadenoma: a case report and literature review

Journal of International Medical Research ◽

10.1177/03000605211013159 ◽

2021 ◽

Vol 49 (5) ◽

pp. 030006052110131

Author(s):

Tingting Sun ◽

Liming Tian ◽

Yunyun Guo ◽

Yu Zheng ◽

Linglong Ouyang ◽

...

Keyword(s):

Transvaginal Ultrasound ◽

Figo Stage ◽

Anaplastic Carcinoma ◽

Mural Nodule ◽

Cystic Tumor ◽

Stage Iiia ◽

Light Yellow ◽

Gynecology And Obstetrics ◽

Rhabdoid Features ◽

Mural Nodules

Anaplastic carcinoma in an ovarian tumor (ACOT) is rare. There have been a few controversial cases illustrating the clinical characteristics and prognostic factors of ACOT, which are not well known. A 60-year-old Chinese woman presented with a large pelvic tumor. A transvaginal ultrasound examination showed a large single ovarian cystic tumor with mural nodules and ascites. A gross ovarian mass with a size of approximately 20 × 10×15 cm3 was found. The content of the ovarian cyst was light yellow and chocolate-like, and a large grayish mural nodule of approximately 10 cm was found on the cyst wall. Histological diagnosis of ovarian mucinous borderline cystadenoma with a mural nodule of anaplastic carcinoma showing rhabdoid features and International Federation of Gynecology and Obstetrics (FIGO) stage IIIa was made. Fifteen months after surgery, the patient had received six courses of paclitaxel and carboplatin. She is still alive without any recurrence of the tumor. Findings from the present case suggest that patients with ACOT and FIGO stage IIIa would benefit from surgery and chemotherapy of paclitaxel and carboplatin. We also review the clinical features and survival rate of patients with ACOT using the Surveillance, Epidemiology, and End Result database, and summarize previously reported treatments.

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Ovarian mucinous tumor with mural nodules of anaplastic carcinoma

Gynecologic Oncology ◽

10.1016/0090-8258(89)90024-3 ◽

1989 ◽

Vol 35 (1) ◽

pp. 112-119 ◽

Cited By ~ 16

Author(s):

Yuen-Fu Chan ◽

H.C. Ho ◽

S.M. Yau ◽

L. Ma

Keyword(s):

Anaplastic Carcinoma ◽

Mucinous Tumor ◽

Mural Nodules

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Like Mural Nodule in Intestinal-Type Mucinous Ovarian Tumor of Borderline Malignancy

Indian Journal of Pathology Research and Practice ◽

10.21088/ijprp.2278.148x.5116.10 ◽

2016 ◽

Vol 5 (1) ◽

pp. 59-60

Author(s):

Punam Prasad Bhadani ◽

◽

Umesh Kumar Bhadani ◽

Keyword(s):

Ovarian Tumor ◽

Intestinal Type ◽

Mural Nodule ◽

Borderline Malignancy

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Mucinous Tumor of the Gallbladder With a Separate Nodule of Anaplastic Carcinoma

Archives of Pathology & Laboratory Medicine ◽

10.5858/1999-123-1280-mtotgw ◽

1999 ◽

Vol 123 (12) ◽

pp. 1280-1284

Author(s):

Tsutomu Mizuno ◽

Tadaaki Eimoto ◽

Toyohiro Tada ◽

Hisashi Tateyama ◽

Hiroshi Inagaki ◽

...

Keyword(s):

Preoperative Diagnosis ◽

Epithelial Membrane Antigen ◽

Immunohistochemical Study ◽

Anaplastic Carcinoma ◽

Mucinous Tumor ◽

First Report ◽

Cystic Tumors ◽

Old Japanese ◽

Atypical Cells ◽

Mural Nodules

Abstract A case of mucinous tumor of the gallbladder with a separate nodule of anaplastic carcinoma is reported. The patient was an 83-year-old Japanese man who underwent cholecystectomy under the preoperative diagnosis of a mucus-producing gallbladder tumor. A mucinous tumor was found in the neck and distal body of the gallbladder, associated with a separate nodule in the fundus. The latter nodule was initially diagnosed as a benign xanthogranulomatous lesion. However, the immunohistochemical study revealed that the atypical cells in the superficial part of the nodule were positive for cytokeratin and epithelial membrane antigen, confirming the diagnosis of anaplastic carcinoma. Although the occurrence of mural nodules in mucinous cystic tumors of the ovary and pancreas is well reported, to our knowledge, this is the first report on the occurrence of a mucinous tumor with a nodule of anaplastic carcinoma in the gallbladder.

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Ovarian Mucinous Tumor with Mural Nodules of Anaplastic Carcinoma: A Clinicopathological Analysis of Three Cases Report and Review of Related Literature

10.21203/rs.3.rs-506316/v1 ◽

2021 ◽

Author(s):

Xiaojuan Wang ◽

Pei Wang ◽

Yanfeng Xi ◽

Peng Bu ◽

Chunyan Wang

Keyword(s):

Mucinous Adenocarcinoma ◽

Young Patients ◽

Germline Mutations ◽

Anaplastic Carcinoma ◽

Missense Mutations ◽

Mucinous Tumor ◽

Wild Type ◽

Molecular Features ◽

Cystic Tumors ◽

Mural Nodules

Abstract Background:Anaplastic carcinoma mural nodules presenting in ovarian mucinous cystic tumors are very rare. Here, we reported clinicopathological, immunohistochemical and molecular features of 3 such cases, and reviewed the related literature.Case presentation:The expression of pan-cytokeratin (CK) in the mural nodules of all three patients supported the diagnosis of mural nodules of anaplastic carcinoma. Immunohistochemical staining showed wild-type expression of p53 in the mural nodules and mucinous epithelium of Cases 2 and 3, while Case 1 was negative for the p53 mutation. The synchronous expression of p53 in epithelia and mural nodules suggested that mural nodules might be homologous with mucinous adenocarcinoma and might be the result of dedifferentiation of mucinous adenocarcinoma. In the sarcomatoid region of Case 1, p53 was wild-type in spindle cells and multinucleated giant cells in the background. In Case 3, a broad-based serrated adenoma of the appendix was also found. Therefore, exons of tumor-related genes were detected by high-throughput next-generation sequencing (NGS). Missense mutations of PIK3CA and PTEN were found, but no germline mutations were detected.Conclusions:In young patients with sarcomalike mural nodule (SLMNs) morphology, pathological analysis is recommended to avoid overlooking the existence of malignant mural nodules. Serrated lesions occurred in the appendix and ovarian mucinous tumor simultaneously, but no germline mutations were detected by NGS, indicating this was a sporadic case.

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Causes of Hyperprolactinemia in Acromegalic Patients and Clinical Correlations

Austin Journal of Endocrinology and Diabetes ◽

10.26420/austinjendocrinoldiabetes.2021.1080 ◽

2021 ◽

Vol 8 (1) ◽

Author(s):

Matos T ◽

◽

Gomes V ◽

Faria C ◽

Gomes A ◽

...

Keyword(s):

Growth Hormone ◽

Cavernous Sinus ◽

Transsphenoidal Surgery ◽

Clinical Course ◽

Course Of Disease ◽

Cavernous Sinus Invasion ◽

Positive Immunostaining ◽

Clinical Correlations ◽

Level Of Significance ◽

Worse Prognosis

Hyperprolactinemia in acromegalic patients may result either from cosecretion of growth hormone and prolactin by the tumour or from pituitary stalk compression. The occurrence of both conditions is possible. This study was designed aiming 1) to estimate the prevalence of each cause of hyperprolactinemia and its respective clinical course; 2) to compare the outcomes of patients with tumours staining only for growth hormone against tumours staining for both growth hormone and prolactin. 75 acromegalic patients submitted to transsphenoidal surgery between 1989 and 2018 were included. Patients were divided based on preoperative prolactin levels and immunostaining pattern. Statistical analysis was performed with SPSS version 23. Hyperprolactinemia was documented in 22 out of 36 patients (61%). Stalk compression was the only underlying cause of hyperprolactinemia in 45% of cases. The levels of prolactin were not associated with the immunostaining pattern for prolactin. Clinical differences were not observed between hyperprolactinemic and normoprolactinemic patients, except for a higher frequency of cavernous sinus invasion (64% vs 29%, p=0,064), that reached the level of significance for the subgroup with macroadenomas staining exclusively for growth hormone (p=0,031). In the present series, no clinical differences were noticed between patients with tumours staining only for growth hormone or staining for both growth hormone and prolactin. Hyperprolactinemia resulting from stalk compression is likely to anticipate a less favourable course of disease, since it is associated with larger tumours and a higher frequency of cavernous sinus invasion. On the contrary, positive immunostaining for prolactin was not a marker of worse prognosis.

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