Mucinous Tumor of the Gallbladder With a Separate Nodule of Anaplastic Carcinoma

1999 ◽  
Vol 123 (12) ◽  
pp. 1280-1284
Author(s):  
Tsutomu Mizuno ◽  
Tadaaki Eimoto ◽  
Toyohiro Tada ◽  
Hisashi Tateyama ◽  
Hiroshi Inagaki ◽  
...  
Keyword(s):  
Preoperative Diagnosis ◽  
Epithelial Membrane Antigen ◽  
Immunohistochemical Study ◽  
Anaplastic Carcinoma ◽  
Mucinous Tumor ◽  
First Report ◽  
Cystic Tumors ◽  
Old Japanese ◽  
Atypical Cells ◽  
Mural Nodules

Abstract A case of mucinous tumor of the gallbladder with a separate nodule of anaplastic carcinoma is reported. The patient was an 83-year-old Japanese man who underwent cholecystectomy under the preoperative diagnosis of a mucus-producing gallbladder tumor. A mucinous tumor was found in the neck and distal body of the gallbladder, associated with a separate nodule in the fundus. The latter nodule was initially diagnosed as a benign xanthogranulomatous lesion. However, the immunohistochemical study revealed that the atypical cells in the superficial part of the nodule were positive for cytokeratin and epithelial membrane antigen, confirming the diagnosis of anaplastic carcinoma. Although the occurrence of mural nodules in mucinous cystic tumors of the ovary and pancreas is well reported, to our knowledge, this is the first report on the occurrence of a mucinous tumor with a nodule of anaplastic carcinoma in the gallbladder.

scholarly journals Ovarian Mucinous Tumor with Mural Nodules of Anaplastic Carcinoma: A Clinicopathological Analysis of Three Cases Report and Review of Related Literature

2021 ◽  
Author(s):  
Xiaojuan Wang ◽  
Pei Wang ◽  
Yanfeng Xi ◽  
Peng Bu ◽  
Chunyan Wang
Keyword(s):  
Mucinous Adenocarcinoma ◽  
Young Patients ◽  
Germline Mutations ◽  
Anaplastic Carcinoma ◽  
Missense Mutations ◽  
Mucinous Tumor ◽  
Wild Type ◽  
Molecular Features ◽  
Cystic Tumors ◽  
Mural Nodules

Abstract Background:Anaplastic carcinoma mural nodules presenting in ovarian mucinous cystic tumors are very rare. Here, we reported clinicopathological, immunohistochemical and molecular features of 3 such cases, and reviewed the related literature.Case presentation:The expression of pan-cytokeratin (CK) in the mural nodules of all three patients supported the diagnosis of mural nodules of anaplastic carcinoma. Immunohistochemical staining showed wild-type expression of p53 in the mural nodules and mucinous epithelium of Cases 2 and 3, while Case 1 was negative for the p53 mutation. The synchronous expression of p53 in epithelia and mural nodules suggested that mural nodules might be homologous with mucinous adenocarcinoma and might be the result of dedifferentiation of mucinous adenocarcinoma. In the sarcomatoid region of Case 1, p53 was wild-type in spindle cells and multinucleated giant cells in the background. In Case 3, a broad-based serrated adenoma of the appendix was also found. Therefore, exons of tumor-related genes were detected by high-throughput next-generation sequencing (NGS). Missense mutations of PIK3CA and PTEN were found, but no germline mutations were detected.Conclusions:In young patients with sarcomalike mural nodule (SLMNs) morphology, pathological analysis is recommended to avoid overlooking the existence of malignant mural nodules. Serrated lesions occurred in the appendix and ovarian mucinous tumor simultaneously, but no germline mutations were detected by NGS, indicating this was a sporadic case.

scholarly journals Mucinous Ovarian Tumors With Anaplastic Mural Nodules: Case Report

2021 ◽  
Vol 8 ◽  
Author(s):  
Xinxin Zou ◽  
Hao Huang ◽  
Qingyu Zhang ◽  
Zhen Ma ◽  
Yumei Chen ◽  
...  
Keyword(s):  
Surgical Excision ◽  
Exploratory Laparotomy ◽  
Cystic Mass ◽  
Anaplastic Carcinoma ◽  
Diagnostic Methods ◽  
Cystic Tumors ◽  
Partition Walls ◽  
Poorly Differentiated ◽  
The Right ◽  
Mural Nodules

Ovarian mucinous cystic tumors may be associated with various types of mural nodules, which can be classified as benign or malignant (anaplastic carcinoma, sarcoma, carcinosarcoma). However, anaplastic malignant nodules have rarely been reported. Here, we present a case of a 35-year-old woman who presented with abdominal discomfort. Ultrasonography showed a large cystic mass in the pelvic and abdominal cavities measuring 337 × 242 mm. Abdominal computed tomography revealed upper anterior and posterior uterine pelvic cystic lesions based on multiple nodule partition walls and classes. During hospitalization, the patient underwent exploratory laparotomy, which revealed a poorly differentiated ovarian malignant tumor, and subsequent surgical excision was performed. The pathological analysis of the surgical samples of the right ovary revealed a mucinous ovarian tumor, while the mural nodules were classified as anaplastic carcinoma. After surgery, the patient started receiving chemotherapy. Unfortunately, the patient died 6 months later. Mucinous tumor occurring with an anaplastic carcinoma is rare, and the current diagnostic methods are not sufficient in providing an early and accurate diagnosis. Most patients are already in the advanced stage upon diagnosis and combined with poorly differentiated pathological features, the prognosis is extremely poor. Clinicians need to improve the clinical evaluation before surgery and conduct preoperative preparation and communication to improve the prognosis of patients as much as possible.

Carcinosarcoma-like mural nodule in intestinal-type mucinous ovarian of borderline malignancy: a case report

2005 ◽  
Vol 15 (3) ◽  
pp. 549-553 ◽  
Author(s):  
W.-C. Chang ◽  
B.-C. Sheu ◽  
M.-C. Lin ◽  
S.-N. Chow ◽  
S.-C. Huang
Keyword(s):  
Anaplastic Carcinoma ◽  
Intestinal Type ◽  
Mural Nodule ◽  
Mucinous Tumor ◽  
Course Of Disease ◽  
Intraepithelial Carcinoma ◽  
Borderline Malignancy ◽  
Epithelial Atypia ◽  
Worse Prognosis ◽  
Mural Nodules

Epithelial ovarian tumors of borderline malignancy are tumors with histologic features and biologic behavior between benign and frankly malignant epithelial ovarian neoplasms. To date, we cannot accurately predict the patients who are prone to an aggressive course of disease. Here, we present a 35-year-old patient with carcinosarcoma-like mural nodule in intestinal-type mucinous ovarian tumor of borderline malignancy. Foci of intraepithelial carcinoma (about 10%) without stromal invasion are also noted. Total hysterectomy, bilateral salpingo-oophorectomy, appendectomy, and omentectomy were performed, and the frozen pathology during operation showed mucinous tumor of borderline malignancy of left ovary on April 18, 2002. The patient was followed at our outpatient department for 19 months after operation and was free of the disease without any adjuvant chemotherapy. It is difficult to determine whether intestinal-type borderline mucinous tumors with intraepithelial carcinoma are associated with a worse prognosis compared with those with epithelial atypia alone due to disparate results in the published literature. In contrast, most patients with mural nodules of anaplastic carcinoma have had a malignant, often rapid, course. However, too few cases of carcinosarcoma-like mural nodule in mucinous tumor have been published to warrant a conclusion regarding their prognosis.

Ovarian mucinous tumor with mural nodules of anaplastic carcinoma

1989 ◽  
Vol 35 (1) ◽  
pp. 112-119 ◽  
Author(s):  
Yuen-Fu Chan ◽  
H.C. Ho ◽  
S.M. Yau ◽  
L. Ma
Keyword(s):  
Anaplastic Carcinoma ◽  
Mucinous Tumor ◽  
Mural Nodules

scholarly journals Benign Mucinous Tumor of Ovary with a Sarcoma-Like Mural Nodule: A Case Report

2012 ◽  
Vol 2012 ◽  
pp. 1-2
Author(s):  
Sailabala Garikaparthi ◽  
Renuka Inuganti Venkata ◽  
Krishna Bharathi Yarlagadda ◽  
Annapurna Parvatala
Keyword(s):  
Case Report ◽  
Ovarian Tumor ◽  
Anaplastic Carcinoma ◽  
Mural Nodule ◽  
Mucinous Tumor ◽  
Middle Aged ◽  
Worse Prognosis ◽  
Mural Nodules

Sarcoma-like mural nodules occur predominantly in middle-aged women. Distinction of these lesions from true sarcomatous nodules and foci of anaplastic carcinoma is important because of the worse prognosis of these tumors in comparison with the favorable behavior of sarcoma-like mural nodules. In this report we describe the case of a 35-year-old woman with a mucinous ovarian tumor having a mural nodule in the wall.

Cytokeratin and Epithelial Membrane Antigen Expression in Angiosarcomas: An Immunohistochemical Study of 33 Cases

2007 ◽  
Vol 131 (2) ◽  
pp. 288-292 ◽  
Author(s):  
Mousa A. Al-Abbadi ◽  
Nidal M. Almasri ◽  
Samer Al-Quran ◽  
Edward J. Wilkinson
Keyword(s):  
Epithelial Membrane Antigen ◽  
Immunohistochemical Study ◽  
Antigen Expression ◽  
Variable Frequency ◽  
Mesenchymal Tumors ◽  
University Of Florida ◽  
Archival Material ◽  
Immunohistochemical Techniques ◽  
The University ◽  
Age Range

Abstract Context.—Expression of epithelial cell markers can occur in mesenchymal tumors and has been reported in angiosarcomas with variable frequency. In these situations, establishing the diagnosis becomes problematic. Objective.—To determine the expression of cytokeratin and epithelial membrane antigen in angiosarcoma. Design.—To address this issue, 33 well-documented cases of angiosarcomas were retrieved from the archival material of Shands Hospital at the University of Florida, Gainesville, and Jackson Memorial Hospital at the University of Miami, Miami, Florida. These cases were all reviewed and studied using a cytokeratin cocktail (CAM 5.2 and AE1/AE3) and epithelial membrane antigen using standard immunohistochemical techniques. All 33 cases had available material for cytokeratin analysis; however, only 20 cases had enough material for epithelial membrane antigen staining. Results.—In the 33 cases studied, the age range of the patients was 2 to 88 years (mean, 63 years). There were 23 (70%) men and 10 (30%) women. One (3%) of 33 was cytokeratin-immunoreactive and 2 (10%) of 20 were epithelial membrane antigen-immunoreactive. Conclusion.—Cytokeratin and epithelial membrane antigen immunoreactivity in angiosarcomas is infrequent but may be encountered. Interpretation of such expression should be done with caution and in conjunction with the characteristic clinical and morphologic features of the tumor as well as the expression of endothelial cell antigens.

Paget's Disease in Gynecomastia: Immunohistochemical Study of a Case

1988 ◽  
Vol 74 (2) ◽  
pp. 183-190 ◽  
Author(s):  
Pietro Muretto ◽  
Vincenzo Polizzi ◽  
M. Pia Staccioli
Keyword(s):  
Breast Carcinoma ◽  
Carcinoembryonic Antigen ◽  
Epithelial Membrane Antigen ◽  
Immunohistochemical Study ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Male Breast ◽  
Intraductal Carcinoma ◽  
Review Of The Literature ◽  
Good Tool

A case of Paget's disease and gynecomastia in a 70-year-old man is reported. Paget's disease was connected to an intraductal carcinoma, and the immunohistochemical study revealed similar positivity for cytokeratin A, carcinoembryonic antigen and epithelial membrane antigen in Paget cells and intraductal neoplastic cells whereas Paget cells resulted negative for cytokeratin B and C. The study using monoclonal anti-cytokeratin A (35 βH11), B (34 βE12) and C (34 βB4) could represent a good tool, supporting the theory of a ductal origin of Paget cells. A review of the literature has shown the rarity of Paget's disease in the male breast and revealed only two previous reports with an associated gynecomastia, in 2 patients with Klinefelter's syndrome and infiltrating breast carcinoma.

scholarly journals Periostin in the Cancer Stroma of Mycosis Fungoides Palmaris et Plantaris: A Case Report and Immunohistochemical Study

2016 ◽  
Vol 8 (1) ◽  
pp. 31-35
Author(s):  
Kayo Tanita ◽  
Taku Fujimura ◽  
Aya Kakizaki ◽  
Sadanori Furudate ◽  
Masato Mizuashi ◽  
...  
Keyword(s):  
Case Report ◽  
Mycosis Fungoides ◽  
Rare Variant ◽  
Immunohistochemical Staining ◽  
Immunohistochemical Study ◽  
Good Prognosis ◽  
Lesional Skin ◽  
Cancer Stroma ◽  
Old Japanese ◽  
M2 Phenotype

Mycosis fungoides palmaris et plantaris (MFPP) is a rare variant of mycosis fungoides limited to the palms and soles. Although little is known about the pathogenesis of MFPP, this variant of mycosis fungoides presents a relatively good prognosis. In this report, we describe an 85-year-old Japanese man with MFPP. Immunohistochemical staining revealed the dense deposition of periostin in the cancer stroma, as well as infiltration of CD163+CD206- tumor-associated macrophages (TAMs), which suggested the phenotypes of TAMs were not polarized to the M2 phenotype in the lesional skin of MFPP. Our present case might suggest one of the possible reasons for the good prognosis of MFPP.

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