scholarly journals Challenging of frozen diagnoses of small sclerosing pneumocytoma

2021 ◽  
pp. jclinpath-2020-206729
Author(s):  
Zhanxian Shang ◽  
Yuchen Han ◽  
Jinchen Shao ◽  
Lei Zhu ◽  
Haohua Teng ◽  
...  
Keyword(s):  
Growth Pattern ◽  
Foam Cell ◽  
Frozen Section ◽  
Pulmonary Nodules ◽  
Clinical Information ◽  
Cell Populations ◽  
Cell Accumulation ◽  
Papillary Growth Pattern ◽  
Small Pulmonary Nodules ◽  
Papillary Growth

AimsAn increasing number of small pulmonary nodules are being screened by CT, and an intraoperative diagnosis is necessary for preventing excessive treatment. However, there is limited literature on the frozen diagnosis of small sclerosing pneumocytomas (SPs). In particular, tumours smaller than 1 cm are challenging for pathologists performing intraoperative frozen diagnosis.MethodsIn total, 230 cases of SP were surgically resected between January 2015 and March 2019 at Shanghai Chest Hospital, and of them, 76 cases were smaller than 1 cm. The histology and clinical information of these 76 cases (33.0%, 76/230) were reviewed retrospectively, 54 cases of which were diagnosed intraoperatively, and the pitfalls were summarised. All diagnoses were confirmed on permanent sections and immunohistochemical sections.ResultsHistologically, 78.9% (60/76) of the small SP was dominated by one growth pattern, and solid and papillary growth pattern were the most commonly misdiagnosed circumstances. The rate of intraoperative misdiagnosis of these SP smaller than 1 cm was 11.1% (6/54).ConclusionsThe main reason for misdiagnosis was failure to recognise the dual cell populations and the cellular atypia. Diagnostic clues include the gross morphology, the presence of dual-cell populations and a hypercellular papillary core, foam cell accumulation in glandular spaces and haemorrhage and haemosiderin on the periphery. In spite of awareness of pitfalls some cases may still be essentially impossible to diagnose on frozen section.

Frozen Section Diagnoses of Small Pulmonary Nodules: Accuracy and Clinical Implications

2004 ◽  
Vol 78 (5) ◽  
pp. 1755-1759 ◽  
Author(s):  
Alberto M. Marchevsky ◽  
Chanikarn Changsri ◽  
Indu Gupta ◽  
Clark Fuller ◽  
Ward Houck ◽  
...  
Keyword(s):  
Frozen Section ◽  
Pulmonary Nodules ◽  
Clinical Implications ◽  
Small Pulmonary Nodules

scholarly journals A case of clear cell adenocarcinoma with a predominantly papillary growth pattern in the uterine cervix

2004 ◽  
Vol 43 (3) ◽  
pp. 166-170
Author(s):  
Shizuko KOBAYASHI ◽  
Takashi KITAMURA ◽  
Masaaki JITSUHARA ◽  
Chiyuki KANEKO ◽  
Atsuko MASUNAGA ◽  
...  
Keyword(s):  
Uterine Cervix ◽  
Growth Pattern ◽  
Clear Cell ◽  
Clear Cell Adenocarcinoma ◽  
Papillary Growth Pattern ◽  
Papillary Growth

A case of angioglioma composed of astrocytoma with a papillary growth pattern: Immunohistochemical and ultrastructural studies

2002 ◽  
Vol 19 (2) ◽  
pp. 111-116 ◽  
Author(s):  
Hiroyoshi Suzuki ◽  
Hiroshi Uenohara ◽  
Akihiro Utsunomiya ◽  
Noriko Kurihara ◽  
Shinsuke Suzuki ◽  
...  
Keyword(s):  
Growth Pattern ◽  
Ultrastructural Studies ◽  
Papillary Growth Pattern ◽  
Papillary Growth

scholarly journals Cholangiocarcinoma with intraductal tubular growth pattern versus intraductal papillary growth pattern

2016 ◽  
Vol 29 (3) ◽  
pp. 293-301 ◽  
Author(s):  
Tetsuo Tsukahara ◽  
Yoshie Shimoyama ◽  
Tomoki Ebata ◽  
Yukihiro Yokoyama ◽  
Tsuyoshi Igami ◽  
...  
Keyword(s):  
Growth Pattern ◽  
Papillary Growth Pattern ◽  
Papillary Growth ◽  
Pattern Versus

scholarly journals PATH-16. HISTOPATHOLOGICAL EPENDYMOMA VARIANTS ARE ASSOCIATED WITH DISTINCT CLINICAL PARAMETERS AND DNA METHYLATION PATTERNS

2019 ◽  
Vol 21 (Supplement_6) ◽  
pp. vi146-vi146 ◽  
Author(s):  
Julia E Neumann ◽  
Michael Spohn ◽  
Denise Obrecht ◽  
Martin Mynarek ◽  
Christian Thomas ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Growth Pattern ◽  
Who Classification ◽  
Clear Cell ◽  
Clinical Parameters ◽  
Tanycytic Ependymoma ◽  
Molecular Features ◽  
Papillary Growth Pattern ◽  
Methylation Patterns ◽  
Papillary Growth

Abstract According to the current WHO classification, ependymal tumors are classified as subependymomas, myxopapillary ependymomas, classic ependymomas, anaplastic ependymomas and RELA-fusion positive ependymoma (RELA-EPN). Among classic ependymomas, the WHO defines rare histological variants, i.e. the clear-cell, papillary, and tanycytic ependymoma. In parallel to this WHO classification scheme, DNA methylation patterns can distinguish nine distinct molecular ependymoma subgroups, some of which tightly overlap with certain histopathological subgroups, e.g. subependyomas or myxopapillary ependymomas. Since very little is known about the molecular background of histological classic ependymoma variants, we analyzed histomorphology, clinical parameters and global DNA methylation patterns of diagnosed tanycytic ependymomas (n=12), clear-cell ependymomas (n=14) and papillary ependymomas (n=19). Surprisingly, up to 42% of these variants did not match to ependymomas using a previously published DNA methylation-based classifier for brain tumors. Among the tumors with a match to one of the nine known ependymoma methylation classes, tanycytic ependymomas were predominantly located in the spine, but showed diverse molecular methylation patterns. Most clear-cell ependymomas showed a common histomorphology, were found supratentorially and fell into the methylation class of RELA-EPN. Papillary ependymomas showed a “papillary”, “trabecular” or “pseudo-papillary” growth pattern. Interestingly, a true papillary growth pattern was strongly associated with the molecular class B of posterior fossa ependymoma (PFB), but tumors displayed DNA methylation sites that were significantly different when compared to PFB ependymomas without papillary growth. Our results show that the diagnosis of classic histological ependymoma variants can be challenging. While clear-cell and papillary ependymomas harbor common molecular features, tanycytic ependymoma may not represent a molecularly distinct subgroup.

Adenocarcinoma of the Uterine Cervix with Predominantly Villogladular Papillary Growth Pattern

1997 ◽  
Vol 64 (1) ◽  
pp. 147-152 ◽  
Author(s):  
Tsunehisa Kaku ◽  
Toshiharu Kamura ◽  
Toshiyuki Shigematsu ◽  
Kunihiro Sakai ◽  
Naoyuki Nakanami ◽  
...  
Keyword(s):  
Uterine Cervix ◽  
Growth Pattern ◽  
Papillary Growth Pattern ◽  
Papillary Growth

Gamma Probe-Guided Thoracoscopic Surgery of Small Pulmonary Nodules

2000 ◽  
Vol 86 (4) ◽  
pp. 364-366 ◽  
Author(s):  
Giuseppe Boni ◽  
Calogero Riccardo Bellina ◽  
Mariano Grosso ◽  
Marco Lucchi ◽  
Gianpiero Manca ◽  
...  
Keyword(s):  
Gamma Ray ◽  
Thoracoscopic Surgery ◽  
Frozen Section ◽  
Hot Spot ◽  
Gamma Probe ◽  
Pulmonary Nodules ◽  
Resection Margins ◽  
Histopathological Diagnosis ◽  
Ionic Contrast ◽  
Small Pulmonary Nodules

Video-assisted thoracic surgery (VATS) is an interesting and emerging procedure for the diagnosis and treatment of peripheral pulmonary nodules. We developed a new radioguided surgical technique for the detection during VATS of pulmonary nodules smaller than 2 cm, situated deep in the lung parenchyma and neither visible nor palpable with endoscopic instruments. The procedure is divided into two phases. Two hours before surgery 0.3 ml of a solution composed of 0.2 mL of 99mTc-labeled human serum albumin microspheres (5–10 MBq) and 0.1 mL of non-ionic contrast is injected into the lesion under CT guidance. Then the patient is submitted to VATS. During thoracoscopy a collimated probe of 11 mm diameter connected to a gamma ray detector is introduced via an 11.5 mm trocar and the pleural surface of the suspected area is scanned. A hot spot indicates the presence of the radiolabeled nodule and hence the area to be resected. We treated 39 patients with small pulmonary nodules (mean size, 8.3 mm; range, 4–19 mm). The patients were 27 men and 12 women (mean age, 60.8 years; range, 13–80 years). Nineteen patients had a history of synchronous or metachronous malignancy. In all cases the nodule was detected and resected and the resection margins were pathologically free of tumor. Histological examination showed 21 benign and 18 malignant lesions (7 metastases and 11 primary lung cancers). Nine patients with a frozen section-based histopathological diagnosis of lung cancer without functional contraindications underwent a completion lobectomy by open surgery in the same surgical session. In conclusion, the radiolocalization of small pulmonary nodules by gamma probe during VATS is a safe and easy procedure, with fewer complications and a lower failure rate than other localization techniques.

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