scholarly journals Treatment of recurrent mucosal melanoma of the oral cavity with topical imiquimod and pembrolizumab achieves complete histopathologic remission

2021 ◽  
Vol 9 (10) ◽  
pp. e001219
Author(s):  
Tejus Satish ◽  
Shaheer Khan ◽  
Matt Levin ◽  
Richard Carvajal ◽  
Angela J Yoon

Mucosal melanomas constitute a subtype of melanoma with less effective treatments than cutaneous melanomas. We present a case of oral mucosal melanoma that recurred despite multiple resections and adjuvant temozolomide. Treatment with topical imiquimod combined with pembrolizumab achieved remission. A 56-year-old woman presented with a pigmented mass on her left anterior hard palate. Biopsy revealed malignant melanoma. The patient had resection with neck dissection with 3 months of adjuvant temozolomide due to positive margins. Malignant melanoma involving the hard palate recurred 1 year later requiring additional resection. Two years later, two additional pigmented lesions were found; further resections were deferred due to expected morbidity. Following 6 weeks of topical imiquimod treatment, the lesions shrunk significantly. Adjuvant pembrolizumab was added and complete histopathologic remission was observed in 6 months. The patient remained in remission for 4 years before new melanoma in situ was diagnosed, requiring five additional months of imiquimod. As of April 2021, there is no clinical evidence of melanoma. There are limited reports of oral melanoma treated with topical imiquimod. Here, imiquimod administered in combination with pembrolizumab achieved complete pathologic response.

2004 ◽  
Vol 14 (4) ◽  
pp. 628-632
Author(s):  
N. J. Kingston ◽  
R. W. Jones ◽  
J. Baranyai

Multifocal melanoma and melanoma in situ of the vulva and vagina are uncommon lesions, and our understanding of their natural history is limited. Vulvovaginal melanoma appears to be biologically different from cutaneous melanoma and has more in common with mucosal melanoma. A 60-year-old woman presented in 1977 with a pigmented vulvar lesion. Histologic examination revealed melanoma in situ associated with focal invasive melanoma. She re-presented with recurrent primary melanomas arising in melanoma in situ in 1990 and 1998 and died of widespread metastatic melanoma in 2000. Melanoma in situ of the vulva and vagina is rare and appears to have a relatively slow but definite progression to invasive melanoma. All suspicious pigmented lesions in this region should be biopsied, and if multifocal in situ melanoma is identified, vulvo(vagin)ectomy should be considered.


Author(s):  
I. Matos ◽  
M. Machado ◽  
C. Semedo ◽  
S. Bitoque ◽  
J. Santos ◽  
...  

1989 ◽  
Vol 103 (2) ◽  
pp. 231-233 ◽  
Author(s):  
J. J. Going ◽  
D. M. Kean

AbstractPrimary mucosal melanoma of the head and neck is rare and few published cases give proof that the mucosal site is primary. We present a man with malignant melanoma of the nasal cavity which was associated with melanoma-in-situ of the adjacent mucosa, proving that the lesion was primary. He presented with symptoms due to secondary deposits of melanoma in the brain rather than the more usual nose bleeds or blocked nose. The primary site wasfound when his neurological symptoms were investigated by CT and NMR scans of the head.


Medicina ◽  
2021 ◽  
Vol 57 (9) ◽  
pp. 965
Author(s):  
Philipp Becker ◽  
Andreas Pabst ◽  
Monika Bjelopavlovic ◽  
Daniel Müller ◽  
Peer W. Kämmerer

Oral mucosal melanoma (OMM) represents an extremely rare entity that is associated with a poor prognosis due to late diagnosis and early metastasis. Here, extensive surgical therapy is the therapy of choice. In contrary, for OMM in situ, the respective therapeutical recommendations are lacking. In this case report, treatment modalities of an OMM in situ of the palate, including the maxillary alveolar process, are reported. The tumor relapsed twice despite adequate surgical therapy and reconstruction. Therefore, irradiation was performed as an adjuvant therapy. At a follow-up of two years, the patient was free from recurrences.


Oral Oncology ◽  
2020 ◽  
Vol 110 ◽  
pp. 104805
Author(s):  
Mayank Shastri ◽  
Tom Paterson ◽  
Brian S. Bisase ◽  
Andrew W. Barrett

1996 ◽  
Vol 35 (3) ◽  
pp. 225-226 ◽  
Author(s):  
Katsuko Kikuchi-Numagami ◽  
Taizo Kato ◽  
Hachiro Tagami

2020 ◽  
Vol 28 (5) ◽  
pp. 510-513
Author(s):  
Alessandro Caputo ◽  
Alfonso Califano ◽  
Marco Fabiano ◽  
Vincenzo Altieri ◽  
Pio Zeppa ◽  
...  

A rare disease in an unusual site can closely mimic a typical presentation of a common disease, sometimes with devastating consequences. We present a case of primary amelanotic malignant melanoma of the urethra in a male, with clinical and histological characteristics that could have led to a mistaken diagnosis of high-grade urothelial carcinoma. Amelanotic mucosal melanoma should be suspected in all cases of high-grade mucosal tumors with practically any appearance (epithelioid, sarcomatoid, anaplastic, mixed). Morphological hints pointing toward melanoma—such as the presence of sparse melanin pigment or melanoma in situ—should be sought, and if absent, an immunohistochemical panel comprising S100 and HMB45 should be performed.


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