View from beneath—Pathology in Focus Malignant melanoma of the nasal cavity

1989 ◽  
Vol 103 (2) ◽  
pp. 231-233 ◽  
Author(s):  
J. J. Going ◽  
D. M. Kean
Keyword(s):  
Malignant Melanoma ◽  
Nasal Cavity ◽  
Head And Neck ◽  
Mucosal Melanoma ◽  
Primary Site ◽  
Adjacent Mucosa ◽  
Melanoma In Situ ◽  
Mucosal Site ◽  
The Brain

AbstractPrimary mucosal melanoma of the head and neck is rare and few published cases give proof that the mucosal site is primary. We present a man with malignant melanoma of the nasal cavity which was associated with melanoma-in-situ of the adjacent mucosa, proving that the lesion was primary. He presented with symptoms due to secondary deposits of melanoma in the brain rather than the more usual nose bleeds or blocked nose. The primary site wasfound when his neurological symptoms were investigated by CT and NMR scans of the head.

Recurrent primary vulvovaginal malignant melanoma arising in melanoma in situ – the natural history of lesions followed for 23 years

2004 ◽  
Vol 14 (4) ◽  
pp. 628-632
Author(s):  
N. J. Kingston ◽  
R. W. Jones ◽  
J. Baranyai
Keyword(s):  
Malignant Melanoma ◽  
Natural History ◽  
Metastatic Melanoma ◽  
Cutaneous Melanoma ◽  
Mucosal Melanoma ◽  
Histologic Examination ◽  
Melanoma In Situ ◽  
Pigmented Lesions ◽  
History Of

Multifocal melanoma and melanoma in situ of the vulva and vagina are uncommon lesions, and our understanding of their natural history is limited. Vulvovaginal melanoma appears to be biologically different from cutaneous melanoma and has more in common with mucosal melanoma. A 60-year-old woman presented in 1977 with a pigmented vulvar lesion. Histologic examination revealed melanoma in situ associated with focal invasive melanoma. She re-presented with recurrent primary melanomas arising in melanoma in situ in 1990 and 1998 and died of widespread metastatic melanoma in 2000. Melanoma in situ of the vulva and vagina is rare and appears to have a relatively slow but definite progression to invasive melanoma. All suspicious pigmented lesions in this region should be biopsied, and if multifocal in situ melanoma is identified, vulvo(vagin)ectomy should be considered.

scholarly journals Treatment of recurrent mucosal melanoma of the oral cavity with topical imiquimod and pembrolizumab achieves complete histopathologic remission

2021 ◽  
Vol 9 (10) ◽  
pp. e001219
Author(s):  
Tejus Satish ◽  
Shaheer Khan ◽  
Matt Levin ◽  
Richard Carvajal ◽  
Angela J Yoon
Keyword(s):  
Malignant Melanoma ◽  
Hard Palate ◽  
Mucosal Melanoma ◽  
Topical Imiquimod ◽  
Melanoma In Situ ◽  
Oral Melanoma ◽  
Pigmented Lesions ◽  
Adjuvant Temozolomide ◽  
Oral Mucosal Melanoma

Mucosal melanomas constitute a subtype of melanoma with less effective treatments than cutaneous melanomas. We present a case of oral mucosal melanoma that recurred despite multiple resections and adjuvant temozolomide. Treatment with topical imiquimod combined with pembrolizumab achieved remission. A 56-year-old woman presented with a pigmented mass on her left anterior hard palate. Biopsy revealed malignant melanoma. The patient had resection with neck dissection with 3 months of adjuvant temozolomide due to positive margins. Malignant melanoma involving the hard palate recurred 1 year later requiring additional resection. Two years later, two additional pigmented lesions were found; further resections were deferred due to expected morbidity. Following 6 weeks of topical imiquimod treatment, the lesions shrunk significantly. Adjuvant pembrolizumab was added and complete histopathologic remission was observed in 6 months. The patient remained in remission for 4 years before new melanoma in situ was diagnosed, requiring five additional months of imiquimod. As of April 2021, there is no clinical evidence of melanoma. There are limited reports of oral melanoma treated with topical imiquimod. Here, imiquimod administered in combination with pembrolizumab achieved complete pathologic response.

Malignant melanoma in situ of the palate: Radical treatment or “watch and wait”?

Oral Oncology ◽  
2020 ◽  
Vol 110 ◽  
pp. 104805
Author(s):  
Mayank Shastri ◽  
Tom Paterson ◽  
Brian S. Bisase ◽  
Andrew W. Barrett
Keyword(s):  
Malignant Melanoma ◽  
Watch And Wait ◽  
Radical Treatment ◽  
Melanoma In Situ

scholarly journals Successful Treatment of a Patient with anti-PD1 Antibody-Resistant Advanced Mucosal Melanoma with Nivolumab, Ipilimumab plus Denosumab Combination Therapy

2020 ◽  
Vol 13 (1) ◽  
pp. 271-275 ◽  
Author(s):  
Taku Fujimura ◽  
Yumi Kambayashi ◽  
Kentaro Ohuchi ◽  
Ryo Amagai ◽  
Yota Sato ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Combination Therapy ◽  
Nasal Cavity ◽  
Immune Checkpoint ◽  
Cutaneous Melanoma ◽  
Japanese Population ◽  
Immune Checkpoint Inhibitors ◽  
Checkpoint Inhibitors ◽  
Mucosal Melanoma ◽  
Mutation Burden

Since the incidence of mucosal melanoma is higher in the Japanese population compared to Caucasians, and since mucosal melanoma possesses a lower mutation burden compared to cutaneous melanoma, the efficacy of anti-PD1 antibody (Ab) monotherapy for mucosal melanoma is limited. Therefore, other targeting molecules that enhance the anti-tumor effects of immune checkpoint inhibitors are needed. In this report, we present a case with anti-PD1 Ab-resistant recurrent malignant melanoma of the nasal cavity successfully treated with nivolu­mab, ipilimumab plus denosumab combination therapy.

Malignant Melanoma in situ in a Japanese Psoriatic Patient Treated with Phototherapy

1996 ◽  
Vol 35 (3) ◽  
pp. 225-226 ◽  
Author(s):  
Katsuko Kikuchi-Numagami ◽  
Taizo Kato ◽  
Hachiro Tagami
Keyword(s):  
Malignant Melanoma ◽  
Psoriatic Patient ◽  
Melanoma In Situ

Amelanotic Malignant Melanoma of the Male Urethra: A Potential Diagnostic Pitfall

2020 ◽  
Vol 28 (5) ◽  
pp. 510-513
Author(s):  
Alessandro Caputo ◽  
Alfonso Califano ◽  
Marco Fabiano ◽  
Vincenzo Altieri ◽  
Pio Zeppa ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Common Disease ◽  
High Grade ◽  
Male Urethra ◽  
Unusual Site ◽  
Diagnostic Pitfall ◽  
Melanoma In Situ ◽  
Amelanotic Malignant Melanoma ◽  
Histological Characteristics

A rare disease in an unusual site can closely mimic a typical presentation of a common disease, sometimes with devastating consequences. We present a case of primary amelanotic malignant melanoma of the urethra in a male, with clinical and histological characteristics that could have led to a mistaken diagnosis of high-grade urothelial carcinoma. Amelanotic mucosal melanoma should be suspected in all cases of high-grade mucosal tumors with practically any appearance (epithelioid, sarcomatoid, anaplastic, mixed). Morphological hints pointing toward melanoma—such as the presence of sparse melanin pigment or melanoma in situ—should be sought, and if absent, an immunohistochemical panel comprising S100 and HMB45 should be performed.

scholarly journals Primary Cilium Depletion Typifies Cutaneous Melanoma In Situ and Malignant Melanoma

PLoS ONE ◽  
2011 ◽  
Vol 6 (11) ◽  
pp. e27410 ◽  
Author(s):  
Jinah Kim ◽  
Salma Dabiri ◽  
E. Scott Seeley
Keyword(s):  
Malignant Melanoma ◽  
Primary Cilium ◽  
Cutaneous Melanoma ◽  
Melanoma In Situ
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