Clonality of anti-GM1 IgM antibodies in multifocal motor neuropathy and the Guillain-Barré syndrome

2014 ◽  
Vol 86 (5) ◽  
pp. 502-504 ◽  
Author(s):  
Elisabeth A Cats ◽  
W-Ludo van der Pol ◽  
Anne P Tio-Gillen ◽  
Frank P Diekstra ◽  
Leonard H van den Berg ◽  
...  
Keyword(s):  
Multifocal Motor Neuropathy ◽  
Guillain Barre Syndrome ◽  
Motor Neuropathy ◽  
Igm Antibodies ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

scholarly journals Involvement of serum HSP 70 in Guillain-Barré Syndrome: An exploratory study and a review of current literature

2015 ◽  
Vol 61 (01) ◽  
pp. 61-67
Author(s):  
Aida Loshaj-Shala ◽  
Ana Poceva Panovska ◽  
Katerina Brezovska ◽  
Giangiacomo Beretta ◽  
Ljubica Suturkova ◽  
...  
Keyword(s):  
Chronic Inflammatory Demyelinating Polyneuropathy ◽  
Multifocal Motor Neuropathy ◽  
Guillain Barre Syndrome ◽  
Motor Neuropathy ◽  
Hsp 70 ◽  
Guillain Barré Syndrome ◽  
Different Types ◽  
Guillain Barré ◽  
Shock Proteins ◽  
Altered Serum

The evolutionary conserved family of heat shock proteins (HSP) is responsible for protecting cells against different types of stress. Although the levels of HSP can be readily measured in serum, the levels of HSP 70 in patients Guillain-Barre Syndrome (GBS) have not been studied before. To this aim we investigate whether patients with GBS (n=21) had altered serum HSP 70 levels compared to healthy controls (HC, n=9) and to patients affected by other immune disorders such as multifocal motor neuropathy (MMN, n=4) and chronic inflammatory demyelinating polyneuropathy (CIDP, n=6). The highest HSP 70 value (15.78 ± 1.72 ng/mL) was found in one patient in the GBS group, although we have found that serum HSP70 levels were significantly higher in 2 out of the 21 GBS patients (9.5%). Hence, it is of interest to underline that the patient with the highest HSP70 level, had also the best recovery rate. Моrе extensive research is required in order to support the hypothesis that HSP 70 serum concentration may be a useful biomarker for the prediction of remission outcome for GBS patients.

Wernicke’s encephalopathy post hyperemesis gravidarum misdiagnosed as Guillain-Barre syndrome: lessons for the frontline

2021 ◽  
Vol 14 (3) ◽  
pp. e239977
Author(s):  
Kaushiki Kirty ◽  
Yashendu Sarda ◽  
Annu Jacob ◽  
Delanthabettu Venugopala
Keyword(s):  
Pregnant Woman ◽  
Hyperemesis Gravidarum ◽  
Early Recognition ◽  
Wernicke’S Encephalopathy ◽  
Guillain Barre Syndrome ◽  
Neurological Deficits ◽  
Wernicke's Encephalopathy ◽  
Motor Neuropathy ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

We report a case of a 26-year-old pregnant woman, who presented with subacute limb weakness. This was initially suspected to be Guillain-Barre syndrome but subsequently found to be the motor neuropathy of dry beriberi (vitamin B1, thiamine deficiency) along with associated Wernicke’s encephalopathy (WE). The underlying cause was revealed as hyperemesis gravidarum (HG). HG complicates up to 3% of pregnancies and if severe, without nutritional supplements, may lead to electrolyte disturbances, calorie loss and vitamin deficiency. Although the association of HG and WE was first reported in 1939, it remains an under diagnosed condition with potential for serious and permanent neurological deficits, and some mortality, in both mother and baby. Early recognition of the problem, with timely and careful fluid, electrolyte, glucose and vitamin replacement is needed to avoid complications. We highlight current best practice in the treatment of WE. An open mind to the possibility of HG complications in any pregnant woman presenting with neurological symptoms is probably the most important lesson to learn from the front line.

scholarly journals Concurrent Guillain-Barré syndrome and myositis complicating dengue fever

2020 ◽  
Vol 13 (2) ◽  
pp. e232940 ◽  
Author(s):  
Manisha Gulia ◽  
Preeti Dalal ◽  
Monica Gupta ◽  
Daljinderjit Kaur
Keyword(s):  
Creatine Kinase ◽  
Dengue Fever ◽  
Elevated Serum ◽  
Guillain Barre Syndrome ◽  
Uneventful Recovery ◽  
Motor Neuropathy ◽  
Limb Weakness ◽  
Guillain Barré Syndrome ◽  
Bilateral Lower Limb ◽  
Guillain Barré

Dengue is an arboviral infection that classically presents with fever, headache, joint pain, skin flush and morbilliform rashes. Neurological manifestations are well recognised but their exact incidence is unknown. Though myalgias are common in dengue virus infection, myositis and/or elevated serum creatine kinase is an uncommon complication. Guillain-Barré syndrome is another rare neurological manifestation associated with dengue fever. Here, we report the case of a 21-year-old man with serologically confirmed dengue fever presenting with severe myalgia, bilateral lower and upper limb weakness with raised creatine kinase, MRI suggestive of myositis and myonecrosis and nerve conduction velocity showing bilateral lower limb and axillary sensory motor neuropathy. He was managed conservatively and made an uneventful recovery.

Guillain-Barré syndrome without sensory loss (acute motor neuropathy)

Brain ◽  
1995 ◽  
Vol 118 (4) ◽  
pp. 841-847 ◽  
Author(s):  
L. H. Visser ◽  
F. G. A. Van Der Meché ◽  
P. A. Van Doorn ◽  
J. Meulstee ◽  
B. C. Jacobs ◽  
...  
Keyword(s):  
Guillain Barre Syndrome ◽  
Sensory Loss ◽  
Motor Neuropathy ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

scholarly journals Oligosymptomatic dengue infection: a potential cause of Guillain Barré syndrome

2008 ◽  
Vol 66 (2a) ◽  
pp. 234-237 ◽  
Author(s):  
Cristiane Nascimento Soares ◽  
Mauro Cabral-Castro ◽  
Celina Oliveira ◽  
Luis Claudio Faria ◽  
José Mauro Peralta ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
Dengue Infection ◽  
Acute Disseminated Encephalomyelitis ◽  
Guillain Barre Syndrome ◽  
Igm Antibodies ◽  
Guillain Barré Syndrome ◽  
Previous Infection ◽  
Polymerase Chain ◽  
Guillain Barré ◽  
Dengue Epidemic

BACKGROUND: Dengue infection may cause neurological manifestations such as encephalitis, myelitis, mononeuropathies, acute disseminated encephalomyelitis, and Guillain Barré syndrome (GBS). In endemic regions, the infection course can be oligosymptomatic making difficult the diagnosis of the neurological picture associated with dengue infection. OBJECTIVE: To report dengue infection and GBS association, even in oligosymptomatic cases of this infection. METHOD: During the dengue epidemic in Rio de Janeiro city we looked for GBS cases, testing IgM antibodies for dengue and dengue polymerase chain reaction (PCR) in the cerebrospinal fluid (CSF) and serum. RESULTS: We report seven cases (46.6%), presenting dengue positive IgM in serum but with poor or without clinical symptoms of the previous infection. Two of them had also positive IgM antibodies in CSF. CONCLUSION: These data show that search for dengue infection should be a routine in GBS cases living in endemic areas.

scholarly journals The presence of Mycoplasma pneumoniae infection and GM1 ganglioside antibodies in Guillain-Barré syndrome

2011 ◽  
Vol 5 (06) ◽  
pp. 459-464 ◽  
Author(s):  
Mridula B Sharma ◽  
Rama Chaudhry ◽  
Irum Tabassum ◽  
Nishat Hussain Ahmed ◽  
Jitendra Kumar Sahu ◽  
...  
Keyword(s):  
Mycoplasma Pneumoniae ◽  
Guillain Barre Syndrome ◽  
Gm1 Ganglioside ◽  
Igg Antibodies ◽  
Igm Antibodies ◽  
Significant Difference ◽  
Guillain Barré Syndrome ◽  
Ganglioside Antibodies ◽  
Guillain Barré ◽  
Mycoplasma Pneumoniae Infection

Introduction: Guillain-Barré syndrome (GBS) is an autoimmune disorder affecting the peripheral nervous system, usually triggered by an acute infection. GBS patients are known to have antecedent bacterial infections associated with auto-antibodies to various gangliosides. This investigation aimed to evaluate GBS patients for serological evidence of Mycoplasma pneumoniae infection and anti GM1 ganglioside antibodies. Methodology: This cross-sectional study included 57 pediatric GBS patients, 42 neurological controls (i.e., non-GBS Acute Flaccid Paralysis cases) and 35 non-neurological controls. Enzyme linked immune sorbent assay (ELISA) was performed on the sera of the subjects to detect IgM and IgG antibodies against Mycoplasma (M.) pneumoniae and GM1 gangliosides. Results: The results showed that 15.79% and 21.05% GBS patients were positive for IgG and IgM antibodies against M. pneumoniae as compared to 2.38% (P < 0.05) and 14.2% in non-GBS-AFP and 5.7% and 14.2% in non-neurological controls respectively. Additionally, 43.85% and 38.54% GBS patients were positive for IgG and IgM antibodies against GM1 gangliosides as compared to 38.09% and 28.57% in non-GBS-AFP and 14.2% and 2.84% in non-neurological controls respectively (P < 0.05). Conclusions: Significant difference in levels of IgG antibodies against M. pneumoniae was observed between GBS patients and neurological controls, suggesting M. pneumoniae to be an important antecedent to GBS. Significant difference in levels of anti GM1 ganglioside antibodies (IgG & IgM) was seen between GBS patients and non-neurological controls, highlighting its possible role in the pathogenesis of GBS.

scholarly journals Antibodies to ganglioside GM1 and Campylobacter jejuni in patients with Guillain-Barre syndrome

2005 ◽  
Vol 133 (3-4) ◽  
pp. 123-128 ◽  
Author(s):  
Ivana Basta ◽  
Ljubica Suturkova ◽  
Ana Vujic ◽  
Stojanka Aleksic ◽  
Ana Poceva ◽  
...  
Keyword(s):  
Campylobacter Jejuni ◽  
High Titer ◽  
Guillain Barre Syndrome ◽  
Motor Neuropathy ◽  
Serum Antibodies ◽  
Guillain Barré Syndrome ◽  
Flagellar Protein ◽  
Antecedent Infection ◽  
Guillain Barré

Guillain-Barre syndrome (GBS) is an acute immune mediated neuropathy, polyradiculoneuritis, characterized by rapid onset of symmetric extremity muscle paralysis, areflexia and albuminocytological dissociation in the cerebrospinal fluid (CSF). Recently, the heterogeneity of GBS has been noticed with definition of several GBS variants. The axonal GBS associated with anti-GM1 antibodies is the most important variant with the specific role of Campylobacter jejuni (CJ) in the induction of the disease. The role of our study was to determine the frequency of antecedent infection with CJ in the population of our patients with GBS, the association with anti-GM1 antibodies and the distribution of these antibodies within clinical forms of the disease. The diagnosis of GBS has been established in 17 patients according to clinical, electrophysiological and laboratory (CSF) criteria. The serum antibodies to 63 kDa flagellar protein isolated from CJ serotype 0:19 were determined by ELISA and Western blot and serum anti-GM1 antibodies by ELISA. In relation to the disability score two patients were ambulatory, five were ambulatory with support, seven were bedridden and two patients needed respirator. Five (29%) patients had pure motor, while 12 (71%) had sensorimotor GBS. The crania! nerves were involved in 11 (65%) and 9 (53%) patients had autonomic dysfunction. Electromyoneurography showed primary axonal, predominantly motor neuropathy in 6 (35%) and demyelinating sensorimotor neuropathy in 11 (65%) patients. The CSF protein content ranged from 0.47 to 3.88 g/L. The antecedent infection with CJ was shown by serum antibodies to CJ flagellar protein in 12 (71%) patients. Fifteen (88%) patients had IgG anti-GMI antibodies. Twelve (71%) patients had both antibodies. In relation to the clinical form, anti-CJ antibodies were found in 8 (73%) out of 11 patients with demyelinating GBS and in 4 (66.6%) out of b patients with axonal GBS. The high titer of anti-GM1 antibodies was found in all patients (100%) with axonal and in 9 (82%) out of 11 patients with demyelinating GBS. The association of IgG anti-CJ and IgG anti-GM1 antibodies was found in 4 (66.6%) out of b patients with axonal and in 8 (73%) out of 11 patients with demyelinating GBS. The main features of our patients with GBS were high frequency of antecedent infection with CJ, unusually frequent association with anti-GM1 antibodies, and equally frequent association of anti CJ and anti-GM1 antibodies in both, axonal and demyelinating GBS.

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