scholarly journals 042 Respiratory function and cognitive profile in motor neuron disease

2019 ◽  
Vol 90 (e7) ◽  
pp. A14.2-A14
Author(s):  
William Huynh ◽  
Lara E Sharplin ◽  
Jashelle Caga ◽  
Elizabeth Highton-Williamson ◽  
Matthew C Kiernan
Keyword(s):  
Cognitive Impairment ◽  
Cognitive Function ◽  
Motor Neuron ◽  
Motor Neuron Disease ◽  
Respiratory Function ◽  
Normal Function ◽  
Cognitive Testing ◽  
Respiratory Compromise ◽  
Respiratory Dysfunction ◽  
Non Invasive Ventilation

IntroductionMotor neuron disease (MND) is increasingly recognised as a multisystems disorder with 30–50% of patients having mild to moderate cognitive impairment. Mechanisms of cognitive dysfunction in MND are multifactorial but chronic hypoxia secondary to respiratory dysfunction may contribute to cognitive decline in patients.ObjectivesThe current study aimed to identify the relationship between respiratory function in MND patients and the presence and degree of cognitive impairment.MethodsMND patients were prospectively recruited from a multidisciplinary MND clinic. Patients meeting the criteria for frontotemporal dementia were excluded. Baseline clinical assessments including respiratory function as assessed by spirometry were recorded with FVC ≤ 75% considered to have reduced respiratory function. Cognitive testing was performed utilising the Addenbrooke’s Cognitive Examination (ACE).ResultsFrom a cohort of 100 MND patients 48% were categorised as having impaired respiratory function whilst 52% had normal function. Compared to the group with normal respiratory function (ACE: 86.83±1.5), patients with respiratory dysfunction had significantly reduced cognitive function (ACE: 90.68±0.89, P=0.025). Subscores demonstrated significant differences between the groups with respect to domains in memory, attention with a trend observed in fluency. There was a significant correlation between FVC and ACE scores as well as between FVC and memory and fluency subscores (P<0.01).ConclusionMND patients with respiratory compromise were more likely to develop reduced cognitive function. In addition to improving physical function, it remains plausible that non-invasive ventilation may alter the progression of cognitive impairment in MND patients, thereby potentially improving their overall quality of life and carer burden.

scholarly journals P192 Clinical effectiveness of non-invasive ventilation in patients with Motor Neuron Disease

Thorax ◽  
2015 ◽  
Vol 70 (Suppl 3) ◽  
pp. A173.1-A173
Author(s):  
D Freeman ◽  
A Jothieswaran ◽  
M Mascareno ◽  
N Chaudhry ◽  
S Bokhari ◽  
...  
Keyword(s):  
Motor Neuron ◽  
Motor Neuron Disease ◽  
Clinical Effectiveness ◽  
Invasive Ventilation ◽  
Non Invasive ◽  
Non Invasive Ventilation

scholarly journals Use of non-invasive ventilation in motor neuron disease – a retrospective cohort analysis

2021 ◽  
Vol 18 ◽  
pp. 147997312110638
Author(s):  
Laura J Walsh ◽  
Kevin F Deasy ◽  
Fernando Gomez ◽  
Elizabeth O’Sullivan ◽  
Joseph Eustace ◽  
...  
Keyword(s):  
Motor Neuron ◽  
Motor Neuron Disease ◽  
Neurodegenerative Disorder ◽  
Cohort Analysis ◽  
Invasive Ventilation ◽  
Non Invasive ◽  
Progressive Muscle Weakness ◽  
Non Invasive Ventilation ◽  
Retrospective Cohort Analysis ◽  
Bulbar Onset

Motor neuron disease (MND) is a neurodegenerative disorder which leads to progressive muscle weakness including respiratory muscle decline. The introduction of non-invasive ventilation (NIV) has been shown to improve quality of life, survival and slow the rate of pulmonary function decline. A retrospective chart analysis of patients who attended the MND clinic from 2014 to 2019 at a tertiary-referral, academic, teaching hospital was carried out to evaluate if NIV and greater compliance with NIV was associated with improved survival. 111 patients were included. The mean age at diagnosis was 63.8 years and 61.3% were males. 66.7% of our cohort used NIV and of this 66.7%, 44.1% were compliant. There was a significantly longer survival in those who used NIV ( p = 0.002) and in those who used NIV optimally ( p = 0.02) when both groups were compared to those who did not use NIV. In the bulbar MND group those who were compliant with NIV survived longer than who those who did not use NIV ( p = 0.001). We found a significantly longer survival with the use of NIV, the use of NIV optimally and with use of NIV in those with bulbar onset MND compared to those who did not use NIV.

Experiences of end of life care of patient's with motor neuron disease on non invasive ventilation

2012 ◽  
Vol 2 (Suppl 1) ◽  
pp. A94.2-A94 ◽  
Author(s):  
Kimberley Steel ◽  
Aruna Hodgson ◽  
David Waterman ◽  
Sophie Harrison ◽  
Andrew Bentley
Keyword(s):  
Motor Neuron ◽  
Motor Neuron Disease ◽  
End Of Life ◽  
End Of Life Care ◽  
Life Care ◽  
Invasive Ventilation ◽  
Non Invasive ◽  
Non Invasive Ventilation

Exploring the feasibility of a music-assisted relaxation intervention to assist with the initiation of non-invasive ventilation in people with Motor Neuron Disease

2017 ◽  
Vol 9 (2) ◽  
pp. 86
Author(s):  
Jeanette Tamplin ◽  
Felicity A Baker ◽  
Rebecca Davies ◽  
Eleanor Bajo ◽  
Karen Bolger ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Motor Neuron ◽  
Motor Neuron Disease ◽  
Qualitative Data ◽  
Small Sample ◽  
Invasive Ventilation ◽  
Positive Effects ◽  
Non Invasive ◽  
Non Invasive Ventilation

Background: Transitioning to non-invasive ventilation (NIV) can cause anxiety in people with Motor Neuron Disease (MND), which may reduce adherence rates. Music therapy has demonstrated positive effects with mechanical (invasive) ventilation.Method: This feasibility study examined the effects of music-assisted relaxation (MAR) on NIV adherence, anxiety, and quality of life for people with MND. Data were collected at baseline, 7-days post, and 3-months post NIV implementation.Results: Of 18 consenting participants, 15 chose the MAR condition. Results suggested that supporting NIV transition within the first 7 days may be advantageous for long-term adherence. No effects were found for anxiety or quality of life. Limitations included small sample size, lack of an adequate control, and possible ceiling effects on the instruments used. Qualitative data indicated most participants considered the relaxing and distracting effects of MAR were useful.Conclusions: In this small sample, we found some demand for and acceptability of a music-based intervention in this setting. Participants reported differing experiences of using MAR, and there were technical and logistical issues regarding timely and accessible provision of a MAR intervention within the treatment trajectory of NIV implementation. Conflicting quantitative and qualitative data support the need for mixed method research in this area.

Cognitive impairment in motor neuron disease

2009 ◽  
Vol 71 (6) ◽  
pp. 480-484 ◽  
Author(s):  
R. Gallassi ◽  
P. Montagna ◽  
C. Ciardulli ◽  
S. Lorusso ◽  
V. Mussuto ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Motor Neuron ◽  
Motor Neuron Disease

Improved survival with an ambulatory model of non-invasive ventilation implementation in motor neuron disease

2014 ◽  
Vol 15 (3-4) ◽  
pp. 180-184 ◽  
Author(s):  
Nicole Sheers ◽  
David J. Berlowitz ◽  
Linda Rautela ◽  
Ian Batchelder ◽  
Kim Hopkinson ◽  
...  
Keyword(s):  
Motor Neuron ◽  
Motor Neuron Disease ◽  
Invasive Ventilation ◽  
Non Invasive ◽  
Non Invasive Ventilation

Music-assisted relaxation during transition to non-invasive ventilation in people with motor neuron disease: A qualitative case series

2016 ◽  
Vol 30 (2) ◽  
pp. 74-82
Author(s):  
Rebecca Davies ◽  
Felicity A Baker ◽  
Jeanette Tamplin ◽  
Eleanor Bajo ◽  
Karen Bolger ◽  
...  
Keyword(s):  
Motor Neuron ◽  
Motor Neuron Disease ◽  
Case Series ◽  
Invasive Ventilation ◽  
Non Invasive ◽  
Non Invasive Ventilation
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