A population based study of respiratory function in motor neuron disease patients living in Tayside and North East Fife, Scotland

2007 ◽  
Vol 254 (4) ◽  
pp. 453-458 ◽  
Author(s):  
Shuna Colville ◽  
Robert J. Swingler ◽  
Ian S. Grant ◽  
Fiona L. R. Williams
Keyword(s):  
Motor Neuron ◽  
Motor Neuron Disease ◽  
Respiratory Function ◽  
Population Based ◽  
Population Based Study ◽  
North East

Affective Disorders in Motor Neuron Disease: A Population-Based Study

2006 ◽  
Vol 28 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Scott B. Patten ◽  
Lawrence W. Svenson ◽  
Christopher M. White ◽  
Salma M. Khaled ◽  
Luanne M. Metz
Keyword(s):  
Motor Neuron ◽  
Motor Neuron Disease ◽  
Affective Disorders ◽  
Population Based ◽  
Population Based Study

Motor Neuron Disease: A Disease of Old Age

1993 ◽  
Vol 38 (6) ◽  
pp. 178-182 ◽  
Author(s):  
A.M. Chancellor ◽  
A Hendry ◽  
F. I. Caird ◽  
C.P. Warlow ◽  
A.I. Weir
Keyword(s):  
Motor Neuron ◽  
Motor Neuron Disease ◽  
Elderly Women ◽  
The Elderly ◽  
Population Based ◽  
Adult Onset ◽  
Population Based Study ◽  
Medical Unit ◽  
Negative Prognostic Factor ◽  
Epidemiological Trends

There is little information dealing specifically with motor neuron disease (MND) in the elderly. Given current epidemiological trends, geriatricians will be increasingly called upon to diagnose and manage this condition. We report four patients who presented within a six month period to a geriatric medical unit, and place this experience in the perspective of 229 patients from a population-based study of adult-onset MND in Scotland in 1989 and 1990. In 1990 Scotland had a crude annual incidence of MND of 2.25/100,000; the figure for those over 65 is four times greater. MND is more common in men, but the sex ratio was nearly equal over the age of 65. The risk of presenting with bulbar palsy was greater in women, and even higher in elderly women. This, together with increasing age, is the most important negative prognostic factor in MND. Problems with the diagnosis and management of MND in the elderly are highlighted.

Motor neuron disease and malignancies: results of a population-based study

1988 ◽  
Vol 235 (6) ◽  
pp. 374-375 ◽  
Author(s):  
A. Chi� ◽  
F. Brignolio ◽  
P. Meineri ◽  
M. G. Rosso ◽  
A. Tribolo ◽  
...  
Keyword(s):  
Motor Neuron ◽  
Motor Neuron Disease ◽  
Population Based ◽  
Population Based Study

Clinical heterogeneity of familial motor neuron disease: Report of 11 pedigrees from a population based study in Scotland

1994 ◽  
Vol 124 ◽  
pp. 75-76 ◽  
Author(s):  
Andrew M. Chancellor ◽  
Hazel Fraser ◽  
Robert J. Swingler ◽  
Susan M. Holloway ◽  
Charles P. Warlow
Keyword(s):  
Motor Neuron ◽  
Motor Neuron Disease ◽  
Population Based ◽  
Clinical Heterogeneity ◽  
Population Based Study

Effect of hospital characteristics on outcome of patients with gastric cancer: A population based study in North-East Netherlands

2010 ◽  
Vol 36 (5) ◽  
pp. 449-455 ◽  
Author(s):  
E.J.M. Siemerink ◽  
M. Schaapveld ◽  
J.T.M. Plukker ◽  
N.H. Mulder ◽  
G.A.P. Hospers
Keyword(s):  
Gastric Cancer ◽  
Population Based ◽  
Population Based Study ◽  
North East ◽  
Hospital Characteristics

scholarly journals 042 Respiratory function and cognitive profile in motor neuron disease

2019 ◽  
Vol 90 (e7) ◽  
pp. A14.2-A14
Author(s):  
William Huynh ◽  
Lara E Sharplin ◽  
Jashelle Caga ◽  
Elizabeth Highton-Williamson ◽  
Matthew C Kiernan
Keyword(s):  
Cognitive Impairment ◽  
Cognitive Function ◽  
Motor Neuron ◽  
Motor Neuron Disease ◽  
Respiratory Function ◽  
Normal Function ◽  
Cognitive Testing ◽  
Respiratory Compromise ◽  
Respiratory Dysfunction ◽  
Non Invasive Ventilation

IntroductionMotor neuron disease (MND) is increasingly recognised as a multisystems disorder with 30–50% of patients having mild to moderate cognitive impairment. Mechanisms of cognitive dysfunction in MND are multifactorial but chronic hypoxia secondary to respiratory dysfunction may contribute to cognitive decline in patients.ObjectivesThe current study aimed to identify the relationship between respiratory function in MND patients and the presence and degree of cognitive impairment.MethodsMND patients were prospectively recruited from a multidisciplinary MND clinic. Patients meeting the criteria for frontotemporal dementia were excluded. Baseline clinical assessments including respiratory function as assessed by spirometry were recorded with FVC ≤ 75% considered to have reduced respiratory function. Cognitive testing was performed utilising the Addenbrooke’s Cognitive Examination (ACE).ResultsFrom a cohort of 100 MND patients 48% were categorised as having impaired respiratory function whilst 52% had normal function. Compared to the group with normal respiratory function (ACE: 86.83±1.5), patients with respiratory dysfunction had significantly reduced cognitive function (ACE: 90.68±0.89, P=0.025). Subscores demonstrated significant differences between the groups with respect to domains in memory, attention with a trend observed in fluency. There was a significant correlation between FVC and ACE scores as well as between FVC and memory and fluency subscores (P<0.01).ConclusionMND patients with respiratory compromise were more likely to develop reduced cognitive function. In addition to improving physical function, it remains plausible that non-invasive ventilation may alter the progression of cognitive impairment in MND patients, thereby potentially improving their overall quality of life and carer burden.

Inequalities in the incidence of infectious disease in the North East of England: a population-based study

2014 ◽  
Vol 143 (1) ◽  
pp. 189-201 ◽  
Author(s):  
G. J. HUGHES ◽  
R. GORTON
Keyword(s):  
Infectious Diseases ◽  
Population Based ◽  
Population Based Study ◽  
Sexually Transmitted ◽  
Small Areas ◽  
Vaccine Preventable Diseases ◽  
Bacterial Diseases ◽  
E Coli ◽  
North East ◽  
The North

SUMMARYThe objective of this study was to measure the association between deprivation and incidence of 21 infectious diseases in the North East of England (2007–2011). We used count regression models with the Index of Multiple Deprivation and population/landscape data for small areas (~1500 persons). Deprivation significantly predicted incidence (P < 0·05) for 17 infectious diseases. The direction of association was broadly consistent within groups: increased incidence with increased deprivation for all three bloodborne viruses, 2/3 invasive bacterial diseases, 4/5 sexually transmitted infections (STI) and tuberculosis (TB); decreased incidence with increased deprivation for 5/6 infectious intestinal diseases (IID) and 2/3 vaccine-preventable diseases. Associations were removed for all but one IID (E. coliO157 infection) after accounting for recent foreign travel. Hepatitis C virus, TB and STI are priority infections for reduction of inequalities associated with deprivation in the North East of England.

Survival after Definitive (Chemo)Radiotherapy in Esophageal Cancer Patients: A Population-Based Study in the North-East Netherlands

2012 ◽  
Vol 20 (6) ◽  
pp. 1985-1992 ◽  
Author(s):  
Justin K. Smit ◽  
Christina T. Muijs ◽  
Johannes G. M. Burgerhof ◽  
Gabriel Paardekooper ◽  
Paul R. Timmer ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Cancer Patients ◽  
Population Based ◽  
Population Based Study ◽  
North East ◽  
The North
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