Focal conduction block in compression neuropathy of the proximal sciatic nerve.

Conductive anesthesia as a therapeutic agent for injuries and diseases of the lower extremities is rarely performed. This is primarily due to the fact that the posterior approach is mainly used to perform the sciatic nerve block, which requires special positioning of the patient and is not suitable for inserting a catheter. The most convenient in this respect is the front access to the sciatic nerve. We catheterized the sciatic nerve according to V.V. Kuzmenkov et al. The method of long-term conduction block of the sciatic nerve (DPBS) was performed in 23 patients.

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Mechanism of phospholipase A2-induced conduction block in bullfrog sciatic nerve. II. Biochemistry

Brain Research ◽

10.1016/0006-8993(86)90354-9 ◽

1986 ◽

Vol 373 (1-2) ◽

pp. 392-398 ◽

Cited By ~ 7

Author(s):

John W. Kasckow ◽

Leo G. Abood ◽

Wayne Hoss ◽

Robert M. Herndon

Keyword(s):

Sciatic Nerve ◽

Phospholipase A2 ◽

Conduction Block

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Reversible Conduction Block in Isolated Toad Sciatic Nerve by Emulsified Isoflurane

Anesthesia & Analgesia ◽

10.1213/ane.0b013e3181d2732f ◽

2010 ◽

Vol 110 (4) ◽

pp. 1024-1029 ◽

Cited By ~ 9

Author(s):

Zhuo Li ◽

Jing Yang ◽

Jin Liu ◽

Chun-Yu Gong ◽

Jing Gan ◽

...

Keyword(s):

Sciatic Nerve ◽

Conduction Block

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A microcapsule technique for long-term conduction block of the sciatic nerve by tetrodotoxin

Journal of Neuroscience Methods ◽

10.1016/j.jneumeth.2004.06.007 ◽

2005 ◽

Vol 141 (2) ◽

pp. 199-205 ◽

Cited By ~ 13

Author(s):

Vladimir N. Martinov ◽

Arild Njå

Keyword(s):

Sciatic Nerve ◽

Conduction Block

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Clemastine improves electrophysiologic and histomorphometric changes through promoting myelin repair in a murine model of compression neuropathy

Scientific Reports ◽

10.1038/s41598-021-00389-1 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Jung Il Lee ◽

Jong Woong Park ◽

Kyung Jun Lee ◽

Duk Hee Lee

Keyword(s):

Sciatic Nerve ◽

Functional Recovery ◽

Murine Model ◽

Demyelinating Disease ◽

Surgical Decompression ◽

Myelin Proteins ◽

Compression Phase ◽

Myelin Repair ◽

Compression Neuropathy ◽

G Ratio

AbstractCompression neuropathies are common and debilitating conditions that result in variable functional recovery after surgical decompression. Recent drug repurposing studies have verified that clemastine promotes functional recovery through enhancement of myelin repair in demyelinating disease. We investigated the utility of clemastine as a treatment for compression neuropathy using a validated murine model of compression neuropathy encircling the compression tube around the sciatic nerve. Mice received PBS or clemastine solution for 6 weeks of compression phase. Mice taken surgical decompression received PBS or clemastine solution for 2 weeks of decompression phase. Electrodiagnostic, histomorphometric, and Western immunoblotting analyses were performed to verify the effects of clemastine. During the compression phase, mice treated with clemastine had significantly decreased latency and increased amplitude compared to untreated mice that received PBS. Histomorphometric analyses revealed that mice treated with clemastine had significantly higher proportions of myelinated axons, thicker myelin, and a lower G-ratio. The expression levels of myelin proteins, including myelin protein zero and myelin associated glycoprotein, were higher in mice treated with clemastine. However, the electrophysiologic and histomorphometric improvements were observed regardless of clemastine treatment in mice taken surgical decompression. Mice treated with clemastine during compression of the sciatic nerve demonstrated that clemastine treatment attenuated electrophysiologic and histomorphometric changes caused by compression through promoting myelin repair.

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Conduction block in frog isolated sciatic nerve-gastrocnemius muscle preparation due to electromagnetic stimulation

Biochemical Society Transactions ◽

10.1042/bst0161020 ◽

1988 ◽

Vol 16 (6) ◽

pp. 1020-1020

Author(s):

F. A. WALI ◽

A. I. J. BRAIN

Keyword(s):

Sciatic Nerve ◽

Gastrocnemius Muscle ◽

Conduction Block ◽

Muscle Preparation ◽

Electromagnetic Stimulation

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Acute sciatic neuropathy: "Saturday night palsy"

Srpski arhiv za celokupno lekarstvo ◽

10.2298/sarh0502058m ◽

2005 ◽

Vol 133 (1-2) ◽

pp. 58-61 ◽

Cited By ~ 3

Author(s):

Miodrag Manigoda ◽

Irena Dujmovic-Basuroski ◽

Rajko Trikic ◽

Jelena Drulovic

Keyword(s):

Case Report ◽

Sciatic Nerve ◽

Conduction Block ◽

Common Peroneal Nerve ◽

Complete Recovery ◽

Foot Drop ◽

Plantar Flexors ◽

Saturday Night ◽

Heroin Abuse ◽

Left Calf

This is a case report of 25-year old, unemployed male, admitted to hospital due to acute onset of the left foot drop, subsequent walking difficulty and numbness of the left calf and foot. Symptoms began after prolonged sleep with previous heroin abuse by sniffing. During neurological examination, mild weakness of knee flexors, moderate weakness of plantar flexors and paralysis of foot dorsiflexors, together with hypesthesia of the left calf, foot and fingers, predominantly in the innervation area of common peroneal nerve on the same side, were observed. The electrophysiologic examination revealed predominant involvement of peroneal division within the sciatic nerve, together with recorded conduction block indicating the compression as possible mechanism of nerve injury. The patient was administered corticosteroid therapy during two months, what resulted in almost complete recovery. The peculiarity of this case report is in the presence of the sciatic nerve "Saturday night palsy" with possible effect of former heroin abuse.

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