A comparative study into the one year cumulative incidence of depression after stroke and myocardial infarction

Abstract Abstract Background 5-fluorouracil (5-FU) is the third most commonly used chemotherapeutic agent in the treatment of solid malignancies across the world. The most common manifestation of cardiotoxicity associated with 5-FU is chest pain, presenting as atypical chest pain, angina on exertion or rest and acute coronary syndromes including myocardial infarction and in worse case even death. Nevertheless, a widespread appreciation of 5-FU related cardiotoxicity including myocardial infarction is poorly understood. Purpose This study aims to examine risk of myocardial infarction in patients treated with 5-FU compared to age- and sex-matched population controls. Methods and results Methods: Individuals treated with 5-FU between 2004 and 2014 in the Danish National Patient Register were identified and risk set matching was used to find background population controls matched on age and sex in a 1:5 ratio. Furthermore, two years follow-up time were added with total 13 years. Neither 5-FU patients nor controls had prior ischemic disease. Aalen-Johansen and Kaplan-Meier estimates were used to report the cumulative incidence of myocardial infarction and all-cause mortality, respectively. A multivariable Shared Frailty Cox regression analysis (adjusted for patient age, sex, hypertension, hypercholesterolemia, diabetes, chronic obstructive pulmonary disease, chronic kidney disease, heart failure and atrial fibrillation as well as selected anti-anginal medications including nitrates, beta- and calcium-blockers) was used to determine the association between 5-FU treatment and the one-year risk of myocardial infarction. Results A total of 9,012 5-FU patients and 45,060 controls formed the study population. Differences in comorbid conditions (diabetes, chronic obstructive pulmonary disease, chronic kidney disease, heart failure and atrial fibrillation) and selected anti-anginal medications (nitrates, beta- and calcium-blockers) were non-significant (all P>0.05). The one-year cumulative incidence of myocardial infarction is significantly higher for 5-FU patients at 0.8% versus 0.6% among population controls (Figure 1A), with a competing risk of death of 25.1% versus 1.2%. The risk diminishes beyond one year and becomes lower for 5-FU patients with time (Figure 1A), along with an increasing all-cause mortality (Figure 1B). The unadjusted and adjusted hazard ratio for the one-year risk of myocardial infarction were 1.38 [95% CI 1.07–1.78] and 1.54 [95% CI 1.19–1.99]. Conclusions Although the one-year risk of myocardial infarction is higher among 5-FU patients compared with population controls, the absolute risk is small and becomes insignificant beyond one year of follow-up.

Download Full-text

The One Year Incidence of Postoperative Myocardial Infarction in an Orthopedic Population

HSS Journal ® ◽

10.1007/s11420-007-9070-3 ◽

2007 ◽

Vol 4 (1) ◽

pp. 76-80 ◽

Cited By ~ 28

Author(s):

M. K. Urban ◽

K. Jules-Elysee ◽

C. Loughlin ◽

W. Kelsey ◽

E. Flynn

Keyword(s):

Myocardial Infarction ◽

Postoperative Myocardial Infarction ◽

One Year ◽

The One

Download Full-text

P3601Association of cdkn2b rs2891168 polymorphism with wall motion index score and the development of major adverse cardiovascular events within one year following ST elevation myocardial infarction

European Heart Journal ◽

10.1093/eurheartj/ehz745.0461 ◽

2019 ◽

Vol 40 (Supplement_1) ◽

Author(s):

F A Magamedkerimova ◽

E N Ivantsov ◽

N R Khasanov ◽

E V Valeeva ◽

...

Keyword(s):

Myocardial Infarction ◽

Cardiovascular Events ◽

Wall Motion ◽

St Elevation Myocardial Infarction ◽

Major Adverse Cardiovascular Events ◽

Kaplan Meier ◽

St Elevation ◽

One Year ◽

The One ◽

Cdkn2b Gene

Abstract Introduction According to the GRACE registry the largest amount of deaths occurs in the first year after ST elevation myocardial infarction (STEMI). Purpose To investigate the incidence of Major Adverse Cardiovascular Events (MACE), which include cardiovascular death, nonfatal myocardial infarction, nonfatal stroke one year after STEMI and Wall Motion Index Score (WMSI) in patients with different genotypes A/G of rs2891116 polymorphism in CDKN2B gene. Materials and methods A total of 141 patients, diagnosed with STEMI based on the Third Universal Definition of Myocardial Infarction (ESC, 2013) were included in the study, composed of 52 females and 89 males. The study group mean age was 63.8±11.8 years. Informed consent was obtained. During hospitalization echocardiography was performed and a blood sample was taken for genetic testing. Over the one-year period MACE were recorded. 17 patients were lost to follow up. Data was analysed using Kaplan-Meier estimator; to compare differences between groups log-rank test was applied; continuous data analysis was performed by Mann-Whitney test. The measured genotype frequencies fit the Hardy-Weinberg equilibrium (p>0.05). Results Kaplan-Meier survival analysis revealed that in patients with AA genotype the proportion of individuals who experienced MACE over the one year period after STEMI was higher in comparison with AG genotype carriers (log rank p=0.022). Participants with GG genotype did not show significant differences compared to other genotypes carriers (Picture 1). WMSI value in patients with AA genotype was higher (Me = 1.25; Q(0.25) = 1.13; Q(0.75) = 1.56) than in AG genotype carriers (Me = 1.13; Q(0.25) = 1.13; Q(0.75) = 1.25; p=0.037). In participants with GG genotype compared to AA and AG the WMSI value was not significantly different (Me = 1.19; Q(0.25) = 1.13; Q(0.75) = 1.32). Picture 1 Conclusions Genotype AA in CDKN2B gene rs2891168 in patients after STEMI is associated with higher probability of the development of MACE over the one year period after the index event, compared to AG genotype carriers. Participants with AA genotype exhibited a higher WMSI value after STEMI compared to patients with AG genotype.

Download Full-text

Abstract 228: Inflammasome-Primed Neutrophils Return to the Bone Marrow to Stimulate Leukocytosis Following Myocardial Infarction

Circulation Research ◽

10.1161/res.127.suppl_1.228 ◽

2020 ◽

Vol 127 (Suppl_1) ◽

Author(s):

Prabhakara R Nagareddy ◽

Gopalkrishna Sreejit ◽

Man K Lee ◽

Baskaran Athmanathan ◽

Greg A Quaife-Ryan ◽

...

Keyword(s):

Myocardial Infarction ◽

Bone Marrow ◽

Nlrp3 Inflammasome ◽

Major Adverse Cardiovascular Events ◽

Dependent Manner ◽

New Paradigm ◽

Pyrin Domain ◽

One Year ◽

The One ◽

Sites Of Action

Myocardial infarction (MI) triggers myelopoiesis resulting in heightened number of neutrophils in the circulation. However, the mechanism that sustain their number and recruitment to the infarcted heart are unclear. Here, we show that in a mouse model of MI (permanent ligation of LAD), neutrophils are rapidly recruited to the infarct, where they release specific alarmins, S100A8 and S100A9. These alarmins acting either in an autocrine or paracrine manner, primed the Nod Like Receptor (NLR) family Pyrin Domain Containing 3 (Nlrp3) inflammasome in naïve neutrophils via their interaction with the Toll Like Receptor (TLR) 4. The interaction did not result in the release of IL1β systemically. However, the primed neutrophils, loaded with pro-interleukin-1β (IL-1β) returned to the bone marrow (BM) in a CXCR4 (C-X-C-motif chemokine receptor 4)- dependent manner. While at the BM, the primed-neutrophils released IL-1β through Gasdermin D pores and, stimulated granulopoiesis in a cell-autonomous manner. Strategies aimed at preventing the Nlrp3 inflammasome-priming or re-entry of the primed neutrophils to the BM dampened MI-induced granulopoiesis and markedly improved cardiac function. In subjects with acute ST-elevation myocardial infarction (STEMI), the number of neutrophils in the circulation increased both at the time of admission and following revascularization. Most importantly, patients with higher peak neutrophil counts demonstrated significantly higher incidence of major adverse cardiovascular events (MACE) during the one year follow up period. Similar to mouse data, the plasma levels of IL-1β did not change in STEMI patients at any time. However, the circulating neutrophils carried greater amounts of pro-IL-1β confirming our mouse data that granulopoiesis is likely not induced by systemic but locally delivered IL-1β by reverse migrating neutrophils. These data reveal a new paradigm of how circulatory cells establish direct communication between organs by delivering signaling molecules directly at the sites of action rather through systemically.

Download Full-text

Anistreplase in early acute myocardial infarction and the one-year follow-up

International Journal of Cardiology ◽

10.1016/0167-5273(91)90266-r ◽

1991 ◽

Vol 31 (1) ◽

pp. 39-49 ◽

Cited By ~ 2

Author(s):

Albert J. McNeill ◽

Michael J. Roberts ◽

Carol M. Wilson ◽

Gavin W.N. Dalzell ◽

William Dickey ◽

...

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

One Year ◽

The One

Download Full-text

Skin autofluorescence is elevated in acute myocardial infarction and is associated with the one-year incidence of major adverse cardiac events

Netherlands Heart Journal ◽

10.1007/bf03086239 ◽

2009 ◽

Vol 17 (4) ◽

pp. 162-168 ◽

Cited By ~ 53

Author(s):

D. J. Mulder ◽

P. L. van Haelst ◽

R. Graaff ◽

R. O. Gans ◽

F. Zijlstra ◽

...

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Major Adverse Cardiac Events ◽

Skin Autofluorescence ◽

Cardiac Events ◽

Adverse Cardiac Events ◽

One Year ◽

The One

Download Full-text

Major adverse cardiovascular events after implantation of absorb bioresorbable scaffold: One-year clinical outcomes

SCRIPTA MEDICA ◽

10.5937/scriptamed52-34467 ◽

2021 ◽

Vol 52 (4) ◽

pp. 249-257

Author(s):

Tanja Šobot ◽

Nikola Šobot ◽

Zorislava Bajić ◽

Nenad Ponorac ◽

Rade Babić

Keyword(s):

Myocardial Infarction ◽

Clinical Outcomes ◽

Cardiovascular Events ◽

Major Adverse Cardiovascular Events ◽

Timi Flow Grade ◽

Timi Flow ◽

Absorb Bvs ◽

One Year ◽

The One

Background/Aim: Bioresorbable vascular scaffold (BVS) represents a novel generation of intracoronary devices designed to be fully resorbed after healing of the stented lesion, delivering antiproliferative drug to suppress restenosis, providing adequate diameter of the coronary vessel and preserving the vascular endothelial function. It was supposed that BVS will reduce neointimal proliferation and that their late bioresorption will reduce the negative effects of traditional drug-eluting stents, including the late stent thrombosis, local vessel wall inflammation, loss of coronary vasoreactivity and the need for the long-term dual antiplatelet therapy. The purpose of this research was to investigate efficacy and safety of Absorb everolimus-eluting BVS implantation and the prevalence of major adverse cardiovascular events (MACE) at the mid-term follow-up. Methods: The study encompassed 42 patients selected for BVS implantation and fulfilling inclusion criteria - 37 male and 5 female - admitted to the Dedinje Cardiovascular Institute, Belgrade, Serbia over the one-year period (from January 2015 to January 2016) for percutaneous coronary intervention (PCI). Coronary vessel patency before and after stenting was assessed by the Thrombolysis in Myocardial Infarction flow (TIMI) grades. After the index PCI procedure with BVS all patients were clinically followed by regular (prescheduled or event-driven) visits during the next 12-month period. Results: In the intention-to-treat analysis, all Absorb BVS procedures were successful, without the need for conversion to other treatment modalities. The complete reperfusion (TIMI flow grade 3) after the intervention was established in 97.6 % of patients and 100 % of them achieved the TIMI flow grade ≥ 2. The presence of angina pectoris was reduced significantly by the BVS procedure: stable angina 57.1 % to 11.9 %, (p < 0.001) and unstable angina 31 % to 0 %, respectively (p < 0.001). After the one-year follow-up, the MACE rate was 11.9 %. Myocardial infarction occurred in 4.8 % and the need for PCI reintervention in 2.4 % of cases (not influenced by the gender or the age of patients). There were 4 cases of death (all patients were older and had lower values of left ventricular ejection fraction). Conclusion: The results of the current research demonstrated a high interventional success rate of the Absorb BVS implantation, followed by the early improvement of the anginal status. However, that was not translated into the favourable mid-term clinical outcomes, opening debate about the current status of Absorb BVS and the need for future refinements of stent design and implantation techniques.

Download Full-text

The One-Year Prognostic Value of the Pre-Discharge ECG after the First Acute Myocardial Infarction

Korean Circulation Journal ◽

10.4070/kcj.1988.18.1.41 ◽

1988 ◽

Vol 18 (1) ◽

pp. 41

Author(s):

Yeong Ho Choi ◽

Suck Koo Choi ◽

Won Sang Yoo ◽

Hyun Je Lee

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Prognostic Value ◽

One Year ◽

The One

Download Full-text

Evaluation of endothelial function, of elasticity of vessel wall and their influence on one-year prognosis of patients with myocardial infarction with obstructive and non-obstructive coronary arteries

I P Pavlov Russian Medical Biological Herald ◽

10.23888/pavlovj2020284488-496 ◽

2020 ◽

Vol 28 (4) ◽

pp. 488-496

Author(s):

Olga Fomina ◽

Sergey Stepanovich Yakushin

Keyword(s):

Myocardial Infarction ◽

Endothelial Function ◽

Coronary Arteries ◽

Vessel Wall ◽

Augmentation Index ◽

Study Groups ◽

Morphological Alterations ◽

Significant Difference ◽

One Year ◽

The One

Aim. To carry out comparative analysis of the state of the endothelial function (EF), elasticity of the vessel wall and their influence on one-year prognosis of patients with myocardial infarction (MI) with obstructive and non-obstructive coronary arteries (CA). Materials and Methods. In the first stage, 206 patients were selected diagnosed with MI, of them 103 patients with MI with non-obstructive CA (MINOCA) according to the results of coronaroangiography, and 103 patients with MI with obstructive CA (MIOCA). Using the method of random numbers, 59 patients were selected (34 patients of the first group and 25 of the second group), in whom EF and elastic properties of the arterial wall were evaluated. Patients of both groups were initially comparable in age, gender, clinical and anamneustic characteristics, and also in frequency of application of the main groups of medical drugs that influence prognosis. One-year prognosis of the two groups of patients was studied depending on the presence/absence of functional and morphological alterations of the vessel wall. Results. In evaluation of EF in patients MINOCA, the occlusion index by amplitude (OIA) below threshold values was recorded in 22 of 34 (64.7%) cases of MINOCA and in 22 of 25 (88.0%, р0.05) cases of MIOCA. Here, the average values of OIA were 1.7 (1.5; 2.3) and 1.4 (1.2; 1.8), respectively (р0.05). The values of phase shifts between the channels below the norm were equally frequent in two groups (88.2 and 88.0%, р0.05), and comparison of the average values of this parameter did not show any statistically significant difference. The calculated augmentation index normalized to the pulse rate 75 beats per minute (AIp75), in the study groups was 12.5 (9.9; 17.9) and 18.8 (12.9; 20.8), respectively (р0.05). Reduction of the elasticity of the vessel wall in the group with MINOCA was noted in 82.4% of patients, in the group MIOCA in 100% of cases (р0.05). No statistically significant differences were found in the frequency of cardiovascular events between the groups during a year (р0.05). Conclusion. Functional alterations of the vessel wall (endothelial dysfunction and reduction of elasticity of the vessel wall) in patients with MINOCA were recorded almost in 2/3 of cases, however, their incidence in MIOCA was still higher (88.0%). The one-year prognosis in the study groups MINOCA and MIOCA showed no differences.

Download Full-text