Environmental health criteria 59: principles for evaluating health risks from chemicals during infancy and early childhood: the need for a special approach

AbstractObjectivesTo compare the long-term effects of antenatal betamethasone (ANS, ≤16 mg, =24 mg and >24 mg) in twins on infant and childhood growth.MethodsA retrospective cohort follow up study among 198 twins after ANS including three time points: U1 first neonatal examination after birth and in the neonatal period; U7 examination from the 21st to the 24th month of life and U9 examination from the 60th to the 64th month of life using data from copies of the children’s examination booklets. Inclusion criteria are twin pregnancies with preterm labor, cervical shortening, preterm premature rupture of membranes, or vaginal bleeding, and exposure to ANS between 23+5 and 33+6 weeks. Outcome measures are dosage-dependent and sex-specific effects of ANS on growth (body weight, body length, head circumference, body mass index and ponderal index) up to 5.3 years.ResultsOverall, 99 live-born twin pairs were included. Negative effects of ANS on fetal growth persisted beyond birth, altered infant and childhood growth, independent of possible confounding factors. Overall weight percentile significantly decreased between infancy and early childhood by 18.8%. Birth weight percentiles significantly changed in a dose dependent and sex specific manner, most obviously in female-female and mixed pairs. The ponderal index significantly decreased up to 42.9%, BMI index increased by up to 33.8%.ConclusionsANS results in long-term alterations in infant and childhood growth. Changes between infancy and early childhood in ponderal mass index and BMI, independent of dose or twin pair structure, might indicate an ANS associated increased risk for later life disease.SynopsisFirst-time report on long-term ANS administration growth effects in twin pregnancies, showing persisting alterations beyond birth in infant and childhood growth up to 5.3 years as potential indicator of later life disease risk.

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Land-Use Change and Health Risks in the Process of Urbanization: A Spatiotemporal Interpretation of a Typical Case in Changzhou, China

Land ◽

10.3390/land10080820 ◽

2021 ◽

Vol 10 (8) ◽

pp. 820

Author(s):

Dongyang Yang ◽

Chao Ye ◽

Jianhua Xu

Keyword(s):

Land Use ◽

Land Use Change ◽

Environmental Pollution ◽

Environmental Health ◽

Health Risks ◽

Urban Land ◽

Urban Land Use ◽

Urban Land Expansion ◽

Process Of Urbanization ◽

The Relationship

China has undergone rapid urban expansion in recent decades. At the same time, environmental pollution and its risk to public health have increased. However, the relationship between urban land-use changes and health is ambiguous and insufficiently understood. Based on a typical city-scale case—namely, Changzhou, China—this research aimed to interpret the evolution of health risks alongside land-use change during the process of urbanization. We gathered data from multiple sources, including population mortality data, socioeconomic data, remote-sensing images, data for the points of interest of enterprises, and relevant information on environmental health events and cancers. The results showed that Changzhou’s urbanization was typical insofar as it was characterized by massive growth in industry, a rapid increase in the urban population, and urban land expansion. Health risks related to environmental pollution increased considerably with urban land expansion over time, and they increased with proximity to the pollution. The results from a generalized linear model confirmed that Changzhou’s urbanization triggered increasing health risks. Our study interpreted the relationship between urban land expansion and health risks from a spatiotemporal perspective. It can be used as a reference for urban planning and policymaking with regard to urban environmental health.

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