LECITHINASES IN NORMAL AND IN PATHOLOGICAL CEREBROSPINAL FLUIDS (CSF). I

1955 ◽  
Vol 33 (1) ◽  
pp. 99-106 ◽  
Author(s):  
E. Kovacs
Keyword(s):  
Nervous System ◽  
Peripheral Nervous System ◽  
Enzyme Level ◽  
Normal Group ◽  
Pathological Changes ◽  
Neurologically Normal

More than 480 CSF's were examined for lecithinase activity. No lecithin splitting was evident in definitely normal CSF. In 60% of the neurologically normal group moderate phospholipase level was demonstrated. Activity was found in a slightly higher number (64%) of the CSF's of meningitis patients. Of the poliomyelitis group 74% exhibited activity, with more uniformity in, and with higher, values than the first two groups. This finding is correlated with the pathological changes in the peripheral nervous system. The highest enzyme level was found in the syphilitic group, 80% of which showed positive assays. The CSF's of miscellaneous neurological and psychotic conditions occasionally exhibited intense lecithinase activity.

LECITHINASES IN NORMAL AND IN PATHOLOGICAL CEREBROSPINAL FLUIDS (CSF). I

1955 ◽  
Vol 33 (1) ◽  
pp. 99-106 ◽  
Author(s):  
E. Kovacs
Keyword(s):  
Nervous System ◽  
Peripheral Nervous System ◽  
Enzyme Level ◽  
Normal Group ◽  
Pathological Changes ◽  
Neurologically Normal

More than 480 CSF's were examined for lecithinase activity. No lecithin splitting was evident in definitely normal CSF. In 60% of the neurologically normal group moderate phospholipase level was demonstrated. Activity was found in a slightly higher number (64%) of the CSF's of meningitis patients. Of the poliomyelitis group 74% exhibited activity, with more uniformity in, and with higher, values than the first two groups. This finding is correlated with the pathological changes in the peripheral nervous system. The highest enzyme level was found in the syphilitic group, 80% of which showed positive assays. The CSF's of miscellaneous neurological and psychotic conditions occasionally exhibited intense lecithinase activity.

scholarly journals Pathological changes in the central and peripheral nervous system of young long-term diabetics

Diabetologia ◽  
1968 ◽  
Vol 4 (1) ◽  
pp. 34-43 ◽  
Author(s):  
Edith Reske-Nielsen ◽  
Knud Lundb�k
Keyword(s):  
Nervous System ◽  
Peripheral Nervous System ◽  
Pathological Changes

scholarly journals Pathological changes in the central and peripheral nervous system of young long-term diabetics

Diabetologia ◽  
1970 ◽  
Vol 6 (2) ◽  
pp. 98-103 ◽  
Author(s):  
Edith Reske-Nielsen ◽  
Knud Lundbaek ◽  
Gunnar Gregersen ◽  
Aage Harmsen
Keyword(s):  
Nervous System ◽  
Peripheral Nervous System ◽  
Pathological Changes

scholarly journals Pathological changes in the central and peripheral nervous system of young long-term diabetics

Diabetologia ◽  
1966 ◽  
Vol 1 (3-4) ◽  
pp. 233-241 ◽  
Author(s):  
Edith Reske-Nielsen ◽  
Knud Lundb�k ◽  
Ole J. Rafaelsen
Keyword(s):  
Nervous System ◽  
Peripheral Nervous System ◽  
Pathological Changes

scholarly journals Correlation of Peripheral Nerve Fiber Loss and Trinucleotide Repeats in Machado-Joseph Disease

1998 ◽  
Vol 25 (1) ◽  
pp. 59-63 ◽  
Author(s):  
Bing-wen Soong ◽  
Kon-ping Lin
Keyword(s):  
Nervous System ◽  
Action Potential ◽  
Peripheral Nervous System ◽  
Peripheral Nerves ◽  
Histological Study ◽  
Cag Repeat ◽  
Cag Repeats ◽  
Pathological Changes ◽  
Myelinated Fibers ◽  
Machado Joseph Disease

ABSTRACT:Background:Machado-Joseph disease (MJD) is a dominantly inherited cerebellar ataxia associated with spasticity, ophthalmoplegia and dystonia. There has been no report of electrophysiological or histological alterations of the peripheral nervous system in patients with MJD.Methods:Four patients with MJD were identified by polymerase chain reaction. The peripheral nerves of these patients were subjected to electrophysiological testing and histological study. Correlation analyses were made between various clinical parameters and the electrophysiological and histological changes.Results:Electrophysiological studies demonstrated a marked reduction of sensory action potential, acute denervation changes on needle EMG, as well as mild decrease in the compound motor action potential. Light microscopy of the sural nerves revealed clear loss of myelinated fibers, and morphometry studies showed a loss of large myelinated fibers. Moreover, the severity of these pathological changes was found to be related to the CAG repeat length in the MJD gene.Conclusion:Our findings indicated that the peripheral nervous system was frequently affected in patients with MJD. These findings were similar to those seen in Friedreich's ataxia, suggesting a loss of sensory and motor fibers probably following a lesion of the dorsal root ganglion and the anterior horns in the spinal cord. Furthermore, the number of CAG repeats seems to have an inverse relationship to the extent of pathological changes of the peripheral nerves.

Glucuronyl 3-sulfate occurs exclusively on distal unmyelinated terminals of selected sensory neurons in the peripheral nervous system

1995 ◽  
Vol 53 ◽  
pp. 958-959
Author(s):  
S.S. Spicer ◽  
B.A. Schulte
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cerebral Cortex ◽  
Peripheral Nervous System ◽  
Sensory Neurons ◽  
Sensory Nerves ◽  
Tissue Antigens ◽  
The Central Nervous System ◽  
The Brain ◽  
Leu 7

Generation of monoclonal antibodies (MAbs) against tissue antigens has yielded several (VC1.1, HNK- 1, L2, 4F4 and anti-leu 7) which recognize the unique sugar epitope, glucuronyl 3-sulfate (Glc A3- SO4). In the central nervous system, these MAbs have demonstrated Glc A3-SO4 at the surface of neurons in the cerebral cortex, the cerebellum, the retina and other widespread regions of the brain.Here we describe the distribution of Glc A3-SO4 in the peripheral nervous system as determined by immunostaining with a MAb (VC 1.1) developed against antigen in the cat visual cortex. Outside the central nervous system, immunoreactivity was observed only in peripheral terminals of selected sensory nerves conducting transduction signals for touch, hearing, balance and taste. On the glassy membrane of the sinus hair in murine nasal skin, just deep to the ringwurt, VC 1.1 delineated an intensely stained, plaque-like area (Fig. 1). This previously unrecognized structure of the nasal vibrissae presumably serves as a tactile end organ and to our knowledge is not demonstrable by means other than its selective immunopositivity with VC1.1 and its appearance as a densely fibrillar area in H&E stained sections.

Stimulating Swallowing: Essential Central and Peripheral Nervous System Targets

ASHA Leader ◽  
2011 ◽  
Vol 16 (9) ◽  
pp. 10-13 ◽  
Author(s):  
Ianessa A. Humbert
Keyword(s):  
Nervous System ◽  
Peripheral Nervous System

Questions and Answers

2000 ◽  
Vol 5 (2) ◽  
pp. 3-3
Author(s):  
Christopher R. Brigham ◽  
James B. Talmage
Keyword(s):  
Nervous System ◽  
Peripheral Nervous System ◽  
Spinal Nerve ◽  
Sensory Loss ◽  
Residual Symptoms ◽  
Additional Information ◽  
Questions And Answers ◽  
Motor Nerves ◽  
Symptoms And Signs ◽  
Limited Motion

Abstract Lesions of the peripheral nervous system (PNS), whether due to injury or illness, commonly result in residual symptoms and signs and, hence, permanent impairment. The AMA Guides to the Evaluation of Permanent Impairment (AMA Guides) describes procedures for rating upper extremity neural deficits in Chapter 3, The Musculoskeletal System, section 3.1k; Chapter 4, The Nervous System, section 4.4 provides additional information and an example. The AMA Guides also divides PNS deficits into sensory and motor and includes pain within the former. The impairment estimates take into account typical manifestations such as limited motion, atrophy, and reflex, trophic, and vasomotor deficits. Lesions of the peripheral nervous system may result in diminished sensation (anesthesia or hypesthesia), abnormal sensation (dysesthesia or paresthesia), or increased sensation (hyperesthesia). Lesions of motor nerves can result in weakness or paralysis of the muscles innervated. Spinal nerve deficits are identified by sensory loss or pain in the dermatome or weakness in the myotome supplied. The steps in estimating brachial plexus impairment are similar to those for spinal and peripheral nerves. Evaluators should take care not to rate the same impairment twice, eg, rating weakness resulting from a peripheral nerve injury and the joss of joint motion due to that weakness.

Chronic neonatal mild stress induces long lasting alterations on peripheral nervous system programming in mice

2004 ◽  
Author(s):  
G. Galietta ◽  
A. Capasso ◽  
A. Fortuna ◽  
F. Fabi ◽  
P. Del Basso ◽  
...  
Keyword(s):  
Nervous System ◽  
Peripheral Nervous System ◽  
Mild Stress ◽  
System Programming
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