Thioredoxin and glutaredoxin systems of rat liver cytosol are not influenced by thyroid dysfunction

1989 ◽  
Vol 67 (7) ◽  
pp. 384-387
Author(s):  
Ganesh B. Bhat ◽  
Brian C. W. Hummel ◽  
Paul G. Walfish
Keyword(s):  
Thyroid Hormone ◽  
Rat Liver ◽  
Thyroid Dysfunction ◽  
Thyroid Status ◽  
Liver Cytosol ◽  
Reverse Triiodothyronine ◽  
Hormone Status ◽  
Rat Liver Cytosol

The relation of thyroid hormone status to the function of hepatic cytosolic components activating microsomal reverse triiodothyronine (rT3) 5′-monodeiodination was studied in rats. Hyperthyroidism was induced by administration of thyroxine and hypothyroidism, by thyroidectomy. The DTT-stimulated microsomal rT3 5′-monodeiodination rate was increased by 125% in hyperthyroid rats and reduced to about 30% in hypothyroid rats (when compared with euthyroid animals). Thyroid status was unrelated to NADPH-dependent activation of microsomal 5′-deiodinase by cytosol components or to cytosolic concentrations of thioredoxin and glutaredoxin, which stimulate in vitro microsomal deiodination of thyroid hormone.Key words: hyperthyroidism, hypothyroidism, glutaredoxin, thioredoxin, 5′-deiodinase.

scholarly journals Rat liver tyrosine aminotransferase activity and induction by dexamethasone upon cadmium intoxication

2003 ◽  
Vol 55 (1-2) ◽  
pp. 3-7 ◽  
Author(s):  
Jadranka Dundjerski ◽  
Jelena Predic ◽  
Aleksandra Cvoro ◽  
Gordana Matic
Keyword(s):  
Enzyme Activity ◽  
Gene Transcription ◽  
Rat Liver ◽  
Tyrosine Aminotransferase ◽  
Aminotransferase Activity ◽  
Liver Cytosol ◽  
Cadmium Intoxication ◽  
Rat Liver Cytosol

This study was focused on Cd effects on basal and dexamethasone-induced tyrosine aminotransferase (TAT) activity in the rat liver cytosol. Cadmium (Cd), applied in the dose of 2 mg/kg b.w., stimulated both TAT activity and its induction by dexamethasone, inducing the most prominent alterations 24 h after administration. Doses lower than 2 mg Cd/kg b.w. were ineffective while the higher ones (3 and 4 mg Cd/kg b.w) led to the changes similar to those reached by 2 mg Cd/kg. The in vitro application of different Cd concentrations to the liver cytosol rendered the enzyme activity unchanged suggesting that the metal acted at the level of TAT gene transcription.

In vitro Formation of Glucose 6-Phosphate from 3-Phosphoglycerate by Rat Liver Cytosol

1981 ◽  
Vol 362 (1) ◽  
pp. 47-58 ◽  
Author(s):  
Stéphanie MÖRIKOFER-ZWEZ ◽  
Franziska B. STOECKLIN ◽  
Paul WALTER
Keyword(s):  
Rat Liver ◽  
Liver Cytosol ◽  
Rat Liver Cytosol

Mono- and dimethylation of arsenic in rat liver cytosol in vitro

1996 ◽  
Vol 99 (1-3) ◽  
pp. 147-164 ◽  
Author(s):  
Miroslav Styblo ◽  
Marielle Delnomdedieu ◽  
David J. Thomas
Keyword(s):  
Rat Liver ◽  
Liver Cytosol ◽  
Rat Liver Cytosol
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