Diastereotopic group recognition in the solid state — A unique intramolecular β-cyclodextrin inclusion complex

2001 ◽  
Vol 79 (11) ◽  
pp. 1806-1811
Author(s):  
Manfred T Reetz ◽  
Joachim Rudolph ◽  
Richard Goddard
Keyword(s):  
Crystal Structure ◽  
Solid State ◽  
Inclusion Complex ◽  
Supramolecular Chemistry ◽  
Structure Analysis ◽  
Crystal Structure Analysis ◽  
Close Vicinity ◽  
Cyclodextrin Inclusion ◽  
Cyclodextrin Inclusion Complex ◽  
First Time

The phenomenon of diastereotopic group recognition has been structurally documented for the first time. A diphenylphosphine-modified β-cyclodextrin having two diastereotopic phenyl groups in close vicinity to the inner cavity of this host was prepared. The crystal structure analysis reveals selective intramolecular complexation of one of the two diastereotopic phenyl groups.Key words: supramolecular chemistry, stereotopic group recognition, cyclodextrins, intramolecular complexation.

Solid-state characterization of sertraline base–β-cyclodextrin inclusion complex

2015 ◽  
Vol 107 ◽  
pp. 265-272 ◽  
Author(s):  
Noriko Ogawa ◽  
Takuro Hashimoto ◽  
Takayuki Furuishi ◽  
Hiromasa Nagase ◽  
Tomohiro Endo ◽  
...  
Keyword(s):  
Solid State ◽  
Inclusion Complex ◽  
Cyclodextrin Inclusion ◽  
Cyclodextrin Inclusion Complex ◽  
Solid State Characterization

Complexes of N-Aryltriphenylphosphinimines with Mercury(II) Halides

1999 ◽  
Vol 54 (7) ◽  
pp. 858-862 ◽  
Author(s):  
Thomas P. Braun ◽  
Paul A. Gutsch ◽  
Hans Zimmer
Keyword(s):  
Crystal Structure ◽  
Solid State ◽  
Structure Analysis ◽  
Nmr Spectra ◽  
Crystal Structure Analysis ◽  
Phosphonium Salts ◽  
X Ray

The synthesis, IR and 31P NMR spectra of the complexes of various N-aryltriphenylphosphinimines with some mercury dihalides as well as the corresponding phosphonium salts are reported. It is shown by an X-ray crystal structure analysis of the complex of the unsubstituted phosphinimine with HgCl2 that in the solid state these complexes form dimers via two Hg ∙∙∙ μ2- Cl ∙∙∙ Hg bridges.

Hantzsch 1,4-dihydropyridine esters and analogs: candidates for generating reproducible one-dimensional packing motifs

2009 ◽  
Vol 65 (3) ◽  
pp. 375-381 ◽  
Author(s):  
R. S. Rathore ◽  
B. Palakshi Reddy ◽  
V. Vijayakumar ◽  
R. Venkat Ragavan ◽  
T. Narasimhamurthy
Keyword(s):  
Crystal Structure ◽  
Solid State ◽  
Hydrogen Bonds ◽  
Structure Analysis ◽  
Crystal Structure Analysis ◽  
Structural Requirements ◽  
One Dimensional ◽  
High Binding ◽  
Solid State Materials ◽  
Derivatives Of

Examination of the symmetric Hantzsch 1,4-dihydropyridine ester derivatives of the prototypical nifedipine molecule indicates the tendency of this class of molecule to form a common packing motif. Crystal structure analysis of 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic diesters and analogs reveals that they form extended chains, characterized as the C(6) packing motif, via intermolecular (amine) N—H...O=C (C3,C5 carbonyl) hydrogen bonds. In addition, all the prepared derivatives also satisfy the basic structural requirements for their high binding efficiency to the receptor. The reproducible C(6) packing motif observed among these compounds has a use in the design of solid-state materials.

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