Ion-tagged synthesis of an oligoribonucleotide pentamer — The continuing versatility of TBDMS chemistry

2007 ◽  
Vol 85 (4) ◽  
pp. 274-282 ◽  
Author(s):  
Robert A Donga ◽  
Tak-Hang Chan ◽  
Masad J Damha
Keyword(s):  
Ionic Liquid ◽  
Rna Synthesis ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Solution Phase ◽  
Phase Synthesis ◽  
Resultant Increase ◽  
Synthesis Approach

An oligoribonucleotide has been synthesized in solution, using an ionic-liquid-based soluble tag at a scale several hundred times that of a standard solid-phase synthesis approach. Ogilvie's 2′-TBDMS strategy was adopted, and because of the resultant increase in lipophilicity, it allowed an easier purification of the growing oligomer compared with the previously observed for DNA, which does not require 2′ protection. The procedure is illustrated by the synthesis of the pentaribonucleotide sequence AGAUC, corresponding to a segment of the tRNAfMet from E. coli.Key words: solution-phase RNA synthesis, ionic-liquid tag.

Solid-Phase Synthesis of Potential Molecular Wires. Attachment of Molecular Alligator Clips

1995 ◽  
Vol 413 ◽  
Author(s):  
LeRoy Jones ◽  
James M. Tour
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Electronic Devices ◽  
Molecular Wires ◽  
Solution Phase ◽  
Molecular Electronic ◽  
Phase Synthesis ◽  
Solution Phase Synthesis ◽  
End Groups ◽  
Convergent Approach

ABSTRACTDescribed is the solid-phase and solution-phase synthesis of oligo(2-dodecylphenyleneethynylene) s via an iterative divergent/convergent approach. Synthesized were the monomer, dimer, tetramer, octamer and 16-mer of the oligo(2-dodecylphenylene-thynylene)s. The synthetic protocol for the synthesis and attachment of protected thiol-containing end groups is also described which may serve as molecular alligator clips for adhesion to gold surfaces. These oligomers may act as molecular wires in molecular electronic devices.

Approaches to the High-Throughput Synthesis of Analogues of Dihydroaeruginoic Acid

2000 ◽  
Vol 53 (6) ◽  
pp. 457 ◽  
Author(s):  
Wendy A. Loughlin ◽  
Scott A. Knevitt ◽  
Rachel E. Hosking ◽  
Raymond L. Marshall
Keyword(s):  
High Throughput ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Solution Phase ◽  
Phase Synthesis ◽  
Solution Phase Synthesis

A solution-phase synthesis of dihydroaeruginoic acid (1) was identified for its application towards the high-throughput synthesis of analogues of dihydroaeruginoic acid (1). Development of a solid-phase synthesis of dihydroaeruginoic acid (1) was examined. Simple analogues (11a–f) of dihydroaeruginoic acid (1) were obtained by using solution-phase high-throughput synthesis.

A Lanthanide(III) Triflate Mediated Macrolactonization/Solid-Phase Synthesis Approach for Depsipeptide Synthesis

2015 ◽  
Vol 17 (9) ◽  
pp. 2182-2185 ◽  
Author(s):  
Jordan D. Goodreid ◽  
Eduardo da Silveira dos Santos ◽  
Robert A. Batey
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis ◽  
Synthesis Approach

Development of a practical solid-phase synthesis approach to 1,3,5-triazepan-2,6-diones

Tetrahedron ◽  
2012 ◽  
Vol 68 (36) ◽  
pp. 7472-7478 ◽  
Author(s):  
Joel Boeglin ◽  
Claire Venin ◽  
Gilles Guichard
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis ◽  
Synthesis Approach

Solid-Phase Synthesis of Pyrrole-Imidazole Polyamides by Resin

2014 ◽  
Vol 908 ◽  
pp. 215-219 ◽  
Author(s):  
Li Ying Mo ◽  
Yan Ling Wu ◽  
Min Rui Liu ◽  
Xing Lai Chen ◽  
Yan Ping Ding ◽  
...  
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Rapid Development ◽  
Solution Phase ◽  
Effective Energy ◽  
Environment Friendly ◽  
Phase Synthesis ◽  
Wang Resin ◽  
The Past ◽  
Solution Phase Synthesis

Over the past years, synthesis of pyrrole-imidazole (Py-Im) polyamides has been achieved by solution-phase and solid-phase methods. Comparing with solution-phase synthesis, the solid-phase synthesis has showed great superiority in various aspects. The solid-phase synthesis is a rapid, effective, energy-saving and environment-friendly method, which has been widely used in the synthesis of pyrrole-imidazole polyamides. Many complicated polyamides can be obtained quickly and effectively through this method. By far, the application of the solid-phase synthesis for Py-Im polyamides has made rapid development. Resin as the main carrier, a key substance in solid phase synthesis, consists of two parts: polymer (macromolecular resin) and linking chain (linker). To date, there are many kinds of resins applied in the solid phase synthesis, such as PAM resin, Wang resin, Oxime resin and Clear resin, and so on. In this article, we will focus on the elaboration about the basic principle and application of the four kinds of resins mentioned above in solid-phase synthesis of polyamides. This provides an important reference for development of polyamides.

Combined solution-phase and solid-phase synthesis of 2-amino-7,8-dihydropteridin-6(5H)-ones

2009 ◽  
Vol 50 (50) ◽  
pp. 7082-7085 ◽  
Author(s):  
Axel Metzger ◽  
Lan-Ying Qin ◽  
Andrew G. Cole ◽  
Kurt W. Saionz ◽  
Marc-Raleigh Brescia ◽  
...  
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Solution Phase ◽  
Phase Synthesis ◽  
Combined Solution

Parallel Solution-Phase Synthesis of (Z)-3-(Arylamino)-2,3-dehydroalanine Derivatives and Solid-Phase Synthesis of Fused Pyrimidones.

ChemInform ◽  
2004 ◽  
Vol 35 (38) ◽  
Author(s):  
Petra Cebasek ◽  
Jernej Wagger ◽  
David Bevk ◽  
Renata Jakse ◽  
Jurij Svete ◽  
...  
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Solution Phase ◽  
Phase Synthesis ◽  
Parallel Solution ◽  
Solution Phase Synthesis

A Different Approach to the EGFR Inhibitor Gefitinib Involving Solid-Phase Synthesis

Synlett ◽  
2018 ◽  
Vol 29 (10) ◽  
pp. 1346-1350 ◽  
Author(s):  
Luísa Carvalho ◽  
André Sequeira ◽  
Ana Lourenço ◽  
Luísa Ferreira ◽  
Paula Branco ◽  
...  
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Solid Support ◽  
Egfr Inhibitor ◽  
Phase Synthesis ◽  
Synthetic Strategy ◽  
Colorimetric Assays ◽  
First Time ◽  
Synthesis Approach

An efficient solid-phase synthesis approach is here reported for the first time to prepare the EGFR inhibitor Gefitinib. The five-step synthetic strategy used FMP resin as the solid support, and FTIR and colorimetric assays were used to track the reaction’s progress. Gefitinib was obtained with an overall yield of 40%.

Sign in / Sign up

Export Citation Format

Share Document