Faculty Opinions recommendation of Controlled functionalization of gold nanoparticles through a solid phase synthesis approach.

An efficient solid-phase synthesis approach is here reported for the first time to prepare the EGFR inhibitor Gefitinib. The five-step synthetic strategy used FMP resin as the solid support, and FTIR and colorimetric assays were used to track the reaction’s progress. Gefitinib was obtained with an overall yield of 40%.

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Ion-tagged synthesis of an oligoribonucleotide pentamer — The continuing versatility of TBDMS chemistry

Canadian Journal of Chemistry ◽

10.1139/v07-022 ◽

2007 ◽

Vol 85 (4) ◽

pp. 274-282 ◽

Cited By ~ 4

Author(s):

Robert A Donga ◽

Tak-Hang Chan ◽

Masad J Damha

Keyword(s):

Ionic Liquid ◽

Rna Synthesis ◽

Solid Phase Synthesis ◽

Solid Phase ◽

Solution Phase ◽

Phase Synthesis ◽

Resultant Increase ◽

Synthesis Approach

An oligoribonucleotide has been synthesized in solution, using an ionic-liquid-based soluble tag at a scale several hundred times that of a standard solid-phase synthesis approach. Ogilvie's 2′-TBDMS strategy was adopted, and because of the resultant increase in lipophilicity, it allowed an easier purification of the growing oligomer compared with the previously observed for DNA, which does not require 2′ protection. The procedure is illustrated by the synthesis of the pentaribonucleotide sequence AGAUC, corresponding to a segment of the tRNAfMet from E. coli.Key words: solution-phase RNA synthesis, ionic-liquid tag.

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General Solid-Phase Synthesis Approach To Prepare Mechanism-Based Aspartyl Protease Inhibitor Libraries. Identification of Potent Cathepsin D Inhibitors

Journal of the American Chemical Society ◽

10.1021/ja981812m ◽

1998 ◽

Vol 120 (38) ◽

pp. 9735-9747 ◽

Cited By ~ 44

Author(s):

Christina E. Lee ◽

Ellen K. Kick ◽

Jonathan A. Ellman

Keyword(s):

Protease Inhibitor ◽

Cathepsin D ◽

Solid Phase Synthesis ◽

Solid Phase ◽

Aspartyl Protease ◽

Phase Synthesis ◽

Synthesis Approach ◽

Cathepsin D Inhibitors

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Carbogenic π−Conjugated Domains as the Origin of Afterglow Emission in Carbon Dot−Based Organic Composite films

Materials Chemistry Frontiers ◽

10.1039/d1qm00019e ◽

2021 ◽

Author(s):

Lu Zhai ◽

Xiaoming Ren ◽

Qiang Xu

Keyword(s):

Organic Materials ◽

Solid Phase Synthesis ◽

Solid Phase ◽

Composite Films ◽

Ambient Conditions ◽

Phase Synthesis ◽

Carbon Dot ◽

Synthesis Approach

The development of carbon dot (CD)-based pure organic materials displaying afterglow emission under ambient conditions with readily tunable emissions is highly desired. Herein, a facile solid-phase synthesis approach at ambient...

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