Development of a practical solid-phase synthesis approach to 1,3,5-triazepan-2,6-diones

Tetrahedron ◽  
2012 ◽  
Vol 68 (36) ◽  
pp. 7472-7478 ◽  
Author(s):  
Joel Boeglin ◽  
Claire Venin ◽  
Gilles Guichard
2015 ◽  
Vol 17 (9) ◽  
pp. 2182-2185 ◽  
Author(s):  
Jordan D. Goodreid ◽  
Eduardo da Silveira dos Santos ◽  
Robert A. Batey

Synlett ◽  
2018 ◽  
Vol 29 (10) ◽  
pp. 1346-1350 ◽  
Author(s):  
Luísa Carvalho ◽  
André Sequeira ◽  
Ana Lourenço ◽  
Luísa Ferreira ◽  
Paula Branco ◽  
...  

An efficient solid-phase synthesis approach is here reported for the first time to prepare the EGFR inhibitor Gefitinib. The five-step synthetic strategy used FMP resin as the solid support, and FTIR and colorimetric assays were used to track the reaction’s progress. Gefitinib was obtained with an overall yield of 40%.


2007 ◽  
Vol 85 (4) ◽  
pp. 274-282 ◽  
Author(s):  
Robert A Donga ◽  
Tak-Hang Chan ◽  
Masad J Damha

An oligoribonucleotide has been synthesized in solution, using an ionic-liquid-based soluble tag at a scale several hundred times that of a standard solid-phase synthesis approach. Ogilvie's 2′-TBDMS strategy was adopted, and because of the resultant increase in lipophilicity, it allowed an easier purification of the growing oligomer compared with the previously observed for DNA, which does not require 2′ protection. The procedure is illustrated by the synthesis of the pentaribonucleotide sequence AGAUC, corresponding to a segment of the tRNAfMet from E. coli.Key words: solution-phase RNA synthesis, ionic-liquid tag.


Author(s):  
Lu Zhai ◽  
Xiaoming Ren ◽  
Qiang Xu

The development of carbon dot (CD)-based pure organic materials displaying afterglow emission under ambient conditions with readily tunable emissions is highly desired. Herein, a facile solid-phase synthesis approach at ambient...


RSC Advances ◽  
2014 ◽  
Vol 4 (91) ◽  
pp. 50220-50225 ◽  
Author(s):  
Ying Ji ◽  
Xiaoyang Liu ◽  
Wei Liu ◽  
Ying Wang ◽  
Hongdan Zhang ◽  
...  

Porous CoS2 is synthesized by a modified molten-salt synthesis approach with a specific capacitance as high as 654 F g−1.


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