Iron Carbonyl Complexes of the Diastereomers of cis-(C6H5)(CH3)AsC(CF3)=C(CF3)As(CH3)(C6H5)

1973 ◽  
Vol 51 (6) ◽  
pp. 936-941 ◽  
Author(s):  
W. R. Cullen ◽  
L. Mihichuk
Keyword(s):  
Iron Carbonyl ◽  
Geometric Isomers ◽  
Carbonyl Complexes ◽  
Cis And Trans ◽  
Cis Isomer

The reaction of CF3≡CCF3 with (C6H5)(CH3)As—As(CH3)(C6H5) gave both cis- and trans-(C6H5)(CH3)AsC(CF3)=C(CF3)As(CH3)(C6H5), (L—L), in nearly equal amounts. When hexafluoroacetone is used as solvent the cis-isomer predominates (88%). The two diastereomers of the cis-adduct were isolated and reacted with Fe(CO)5 to afford (L—L)Fe(CO)3 and (L—L)Fe2(CO)6. Two of the three possible geometric isomers of the latter were obtained and their properties allowed assignment of the configuration of the starting ligands. Minor amounts of the symmetric and asymmetric forms of [Fe(CO)3As(CH3)(C6H5)]2 were also obtained through loss of fluorocarbon.

scholarly journals Increases in plasma trans-EETs and blood pressure reduction in spontaneously hypertensive rats

2011 ◽  
Vol 300 (6) ◽  
pp. H1990-H1996 ◽  
Author(s):  
Houli Jiang ◽  
John Quilley ◽  
Anabel B. Doumad ◽  
Angela G. Zhu ◽  
John R. Falck ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Spontaneously Hypertensive Rat ◽  
Blood Pressure Reduction ◽  
Maximal Velocity ◽  
Spontaneously Hypertensive ◽  
Cis And Trans Isomers ◽  
Wistar Kyoto Rat ◽  
Wistar Kyoto ◽  
Cis And Trans ◽  
Cis Isomer

Epoxyeicosatrienoic acids (EETs) are vasodilator, natriuretic, and antiinflammatory lipid mediators. Both cis- and trans-EETs are stored in phospholipids and in red blood cells (RBCs) in the circulation; the maximal velocity ( Vmax) of trans-EET hydrolysis by soluble epoxide hydrolase (sEH) is threefold that of cis-EETs. Because RBCs of the spontaneously hypertensive rat (SHR) exhibit increased sEH activity, a deficiency of trans-EETs in the SHR was hypothesized to increase blood pressure (BP). This prediction was fulfilled, since sEH inhibition with cis-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]benzoic acid (AUCB; 2 mg·kg−1·day−1 for 7 days) in the SHR reduced mean BP from 176 ± 8 to 153 ± 5 mmHg ( P < 0.05), whereas BP in the control Wistar-Kyoto rat (WKY) was unaffected. Plasma levels of EETs in the SHR were lower than in the age-matched control WKY (16.4 ± 1.6 vs. 26.1 ± 1.8 ng/ml; P < 0.05). The decrease in BP in the SHR treated with AUCB was associated with an increase in plasma EETs, which was mostly accounted for by increasing trans-EET from 4.1 ± 0.2 to 7.9 ± 1.5 ng/ml ( P < 0.05). Consistent with the effect of increased plasma trans-EETs and reduced BP in the SHR, the 14,15- trans-EET was more potent (ED50 10−10 M; maximum dilation 59 ± 15 μm) than the cis-isomer (ED50 10−9 M; maximum dilation 30 ± 11 μm) in relaxing rat preconstricted arcuate arteries. The 11,12-EET cis- and trans-isomers were equipotent dilators as were the 8,9-EET isomers. In summary, inhibition of sEH resulted in a twofold increase in plasma trans-EETs and reduced mean BP in the SHR. The greater vasodilator potency of trans- vs. cis-EETs may contribute to the antihypertensive effects of sEH inhibitors.

ChemInform Abstract: The Synthesis of New Thiolato-Bridged Iron Carbonyl Complexes.

ChemInform ◽  
2010 ◽  
Vol 22 (19) ◽  
pp. no-no
Author(s):  
P. M. TREICHEL ◽  
R. A. CRANE ◽  
R. MATTHEWS ◽  
K. R. BONNIN ◽  
D. POWELL
Keyword(s):  
Iron Carbonyl ◽  
Carbonyl Complexes

Five dinuclear iron carbonyl complexes based on substituted tetramethylcyclopentadienyl ligands: synthesis and crystal structures

2014 ◽  
Vol 67 (1) ◽  
pp. 64-71 ◽  
Author(s):  
Zhihong Ma ◽  
Kaiming Guo ◽  
Na Wang ◽  
Hong Wang ◽  
Zhangang Han ◽  
...  
Keyword(s):  
Crystal Structures ◽  
Iron Carbonyl ◽  
Carbonyl Complexes ◽  
Dinuclear Iron

scholarly journals Reaction of cis- and trans-Dichlorotetra(Dimethylsulfoxide)Ruthenium(II) With the Antiviral Drug Acyclovir

2000 ◽  
Vol 7 (6) ◽  
pp. 325-334 ◽  
Author(s):  
Aglaia Koutsodimou ◽  
Giovanni Natile
Keyword(s):  
Trans Isomer ◽  
Early Stage ◽  
Antiviral Drug ◽  
Metallic Substrate ◽  
Purine Base ◽  
Coordination Environment ◽  
Molar Ratios ◽  
Discrete Amount ◽  
Cis And Trans ◽  
Cis Isomer

NMR was used to investigate the reaction of cis- and trans-[RuCl2(DMSO)4] with the antiviral drug acyclovir, a guanine derivative containing the acyclic (2-hydroxo) ethoxymethyl pendant linked to N(9). Studies were performed in aqueous solutions at ambient temperature and at 37 °C, and at various molar ratios. Both isomers yielded two compounds, a monoadduct and a bisadduct, the relative yields being dependent upon the metal to ligand concentration ratios. The products derived from the two Ru isomers displayed identical NMR spectra, suggesting that they have the same coordination environment, however the rate of formation of the monoadduct was higher in the case of the trans isomer than in the case of the cis isomer, while the rate of conversion of the monoadduct into the bisadduct appeared to be similar in both cases. As a consequence in the case of the trans isomer there is accumulation of monoadduct in the early stage of the reaction, whose concentration afterwards decreases with the progress of the reaction. As for platinum, also for ruthenium the preferred binding site is N(7) of the purine base, however, in the case of ruthenium a discrete amount of bisadduct is formed even in the presence of an excess of metallic substrate with respect to the acyclovir ligand; under similar conditions a platinum substrate would have given, nearly exclusively, the monoadduct.

Iron carbonyl complexes of cithiocarbonates. X-ray crystal structure of Fe4(CO)12S(SCH2C5H4FeC5H5)(SCH3)

1981 ◽  
Vol 210 (1) ◽  
pp. C1-C4 ◽  
Author(s):  
Henri Patin ◽  
Gerard Mignani ◽  
Christian Mahe ◽  
Jean-Yves Le Marouille ◽  
Alain Benoit ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Iron Carbonyl ◽  
Carbonyl Complexes ◽  
X Ray
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