A Comparative Proton Magnetic Resonance Study of the Molecular Conformation of Uracil and 6-Aza Uracil Nucleosides and Nucleotides

1973 ◽  
Vol 51 (15) ◽  
pp. 2571-2577 ◽  
Author(s):  
Donald J. Wood ◽  
Frank E. Hruska ◽  
Richard J. Mynott ◽  
Ramaswamy H. Sarma
Keyword(s):  
Magnetic Resonance ◽  
Proton Magnetic Resonance ◽  
Molecular Conformation ◽  
Three Dimensional ◽  
Magnetic Resonance Study ◽  
Magnetic Resonance Data ◽  
Ribose Phosphate ◽  
Resonance Data ◽  
Proton Magnetic Resonance Study ◽  
Proton Magnetic Resonance Data

Proton magnetic resonance data for uridine and uridine-5′-monophosphate, and the corresponding 6-azauracil analogs, are presented and discussed in terms of their overall three dimensional conformations in aqueous solution. The data reveal a destabilizing influence of the 6-aza base upon the gog and g′–g′ conformation of the ribose phosphate moiety.

Cycloaddition d'ylures d'azométhine dérivés de la 3,4-dihydro-6,7-diméthoxy-3-méthoxycarbonyl-isoquinoléine

1991 ◽  
Vol 69 (7) ◽  
pp. 1156-1160 ◽  
Author(s):  
Tahar Lakhlifi ◽  
Ahmed Sedqui ◽  
Bernard Laude ◽  
Nguyen Dinh An ◽  
Joël Vebrel
Keyword(s):  
Magnetic Resonance ◽  
Key Words ◽  
Proton Magnetic Resonance ◽  
Azomethine Ylide ◽  
Magnetic Resonance Data ◽  
Resonance Data ◽  
Azabicyclic Compounds ◽  
Derivatives Of ◽  
Proton Magnetic Resonance Data

Three azomethine ylide precursors including the methyl 3,4-dihydro-6,7-dimethoxyisoquinoline-3carboxylate moiety were synthesized. The 1,3-dipolar species formed from these products react with activated dipolarophilic olefines leading diastereospecifically to derivatives of 4′,5′-dimethoxy-1,2-benzo-4,7-imino-4-methoxycarbonyl-1-cycloheptene. Proton magnetic resonance data allowed the determination of the stereochemistry of the cycloadducts. Key words: cyclic azomethine ylide, azabicyclic compounds, stereochemistry.

A Proton Magnetic Resonance Study of the Effect of 2′-O-Methylation on Ribonucleoside Conformation

1973 ◽  
Vol 51 (7) ◽  
pp. 1099-1106 ◽  
Author(s):  
Frank E. Hruska ◽  
Alan Mak ◽  
Harwant Singh ◽  
David Shugar
Keyword(s):  
Proton Magnetic Resonance ◽  
Molecular Conformation ◽  
Chemical Shifts ◽  
Three Dimensional ◽  
Coupling Constants ◽  
Dimensional Structure ◽  
Aqueous Environment ◽  
Magnetic Resonance Study ◽  
Proton Magnetic Resonance Study ◽  
Methyl Derivatives

The 100- and 220- MHz p.m.r. spectra of uridine, cytidine, and their 2′-O-methyl derivatives are obtained in aqueous solution at several temperatures. The experimental chemical shifts and coupling constants are discussed in terms of the overall molecular conformation. The conclusion is reached that 2′-O-methylation has little effect upon the three-dimensional structure of a nucleoside at the monomer level in an aqueous environment.

Scale of relative Lewis acidities from proton magnetic resonance data

1968 ◽  
Vol 90 (17) ◽  
pp. 4583-4585 ◽  
Author(s):  
John F. Deters ◽  
Patrick A. McCusker ◽  
Richard C. Pilger
Keyword(s):  
Magnetic Resonance ◽  
Proton Magnetic Resonance ◽  
Magnetic Resonance Data ◽  
Resonance Data ◽  
Proton Magnetic Resonance Data
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