AUTORADIOGRAPHIC STUDIES OF THE DISTRIBUTION OF 1-AMINOCYCLOPENTANE CARBOXYLIC ACID IN NORMAL AND CANCEROUS MICE

1962 ◽  
Vol 40 (1) ◽  
pp. 1111-1114 ◽  
Author(s):  
L. Berlinguet ◽  
Nicole Bégin ◽  
L. M. Babineau
Keyword(s):  
Bone Marrow ◽  
Amino Acid ◽  
Carboxylic Acid ◽  
Tumor Cells ◽  
Ehrlich Ascites Tumor ◽  
Sarcoma 180 ◽  
Ascites Tumor ◽  
Ehrlich Ascites

Normal and cancerous mice were injected with 1-aminocyclopentane C14-carboxylic acid and the distribution of the drug in the animals was studied by autoradiography. In normal mice, the amino acid is concentrated selectively by the pancreas and the bone marrow. In cancerous mice (Ehrlich ascites tumor and sarcoma-180), the tumor cells also intensively accumulate the amino acid.

AUTORADIOGRAPHIC STUDIES OF THE DISTRIBUTION OF 1-AMINOCYCLOPENTANE CARBOXYLIC ACID IN NORMAL AND CANCEROUS MICE

1962 ◽  
Vol 40 (8) ◽  
pp. 1111-1114 ◽  
Author(s):  
L. Berlinguet ◽  
Nicole Bégin ◽  
L. M. Babineau
Keyword(s):  
Bone Marrow ◽  
Amino Acid ◽  
Carboxylic Acid ◽  
Tumor Cells ◽  
Ehrlich Ascites Tumor ◽  
Sarcoma 180 ◽  
Ascites Tumor ◽  
Ehrlich Ascites

Normal and cancerous mice were injected with 1-aminocyclopentane C14-carboxylic acid and the distribution of the drug in the animals was studied by autoradiography. In normal mice, the amino acid is concentrated selectively by the pancreas and the bone marrow. In cancerous mice (Ehrlich ascites tumor and sarcoma-180), the tumor cells also intensively accumulate the amino acid.

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